{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:07:07Z","timestamp":1783487227991,"version":"3.55.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1986,8]]},"abstract":"<jats:p>Abstract. Thyroid volume of 1397 German and 303 Swedish adults were estimated by sonography. Thyroid size of 6\u201316 year old Germans (n = 619) was determined and compared with findings on palpation. Thyroid volume was more than twice as great in German (21.4 \u00b1 15.6 ml, mean \u00b1 <jats:sc>sd<\/jats:sc>) than in Swedish adults (10.1 \u00b1 4.9 ml). The echopattern was abnormal in 16% of the Germans and in 3.6% of the Swedes. German children have a thyroid volume ranging from 1.8 \u00b1 0.4 ml at 6 years to 10.8 \u00b1 6.0 ml at 16 years of age. Palpation is by comparison an unreliable method for determining thyroid size. In Germany, the iodine excretion was less in children (n = 619, 39.5 \u00b1 30.5, 34.1 \u03bcg I\/g creatinine, mean \u00b1 <jats:sc>sd<\/jats:sc>, median) than in adults (n = 1193, 83.7 \u00b1 94.4, 62.6), (<jats:italic>P<\/jats:italic> &lt;0.001) and much lower than that observed in Sweden (adults n = 98, 170.2 \u00b1 93.3, 141.4; 13 year olds n = 113, 172.9 \u00b1 224.1, 124), (<jats:italic>P<\/jats:italic> &lt; 0.0001). Serum thyrotropin concentration was significantly higher (<jats:italic>P<\/jats:italic> &lt;0.001) in Sweden (n = 62, 1.49 \u00b1 0.82 mU\/ml), than in Germany (n = 91, 0.97 \u00b1 0.52 mU\/ml), while serum thyroglobulin was increased in Germany (n = 91, 72.6 \u00b1 50.6 \u03bcg\/l) as compared to Sweden (n = 62, 23.5 \u00b1 17.4), (<jats:italic>P<\/jats:italic> &lt;0.0001). These results indicate the goitrogenic effect of iodine deficiency and the continuing need for an effective iodine prophylaxis in the FRG.<\/jats:p>","DOI":"10.1530\/acta.0.1120494","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T21:53:47Z","timestamp":1229378027000},"page":"494-501","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":95,"title":["Goitre epidemiology: thyroid volume, iodine excretion, thyroglobulin and thyrotropin in Germany and Sweden"],"prefix":"10.1093","volume":"112","author":[{"given":"R.","family":"Gutekunst","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Smolarek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U.","family":"Hasenpusch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Stubbe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.-J.","family":"Friedrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. G.","family":"Wood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. C.","family":"Scriba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/112\/4\/acta_112_4_005.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/112\/4\/acta_112_4_005.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:26:50Z","timestamp":1676392010000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/112\/4\/494\/6763934"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,8]]},"references-count":0,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.1120494","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,8]]}}}