{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T05:25:13Z","timestamp":1676438713014},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1986,9]]},"abstract":"<jats:p>Abstract. On forty-six fasting and resting children, aged 5\u201317 years, with short stature (below \u22122 <jats:sc>sd<\/jats:sc>) a growth hormone releasing hormone (GH-RH) stimulation test (2 \u03bcg\/kg iv bolus, Sanofi) was performed. Twenty-two children were prepubertal, of which, 13 had a constitutional short stature (CSS), nine an idiopathic growth hormone deficiency (IGHD). Twenty-four subjects were pubertal, at the stage II or III of Tanner. Among them, six had a constitutional short stature (CSS) and 18 an idiopathic delayed puberty (IDP). Blood samples were taken for determination of plasma somatostatin-like immunoreactivity (SLI) in chilled test tubes containing EDTA + aprotinin. Plasma SLI levels were measured after extraction and concentration on C 18 Sep Pack columns by radioimmunoassay using an antibody against 1\u201314 somatostatin. The sensitivity of this assay is around 3 pg\/ml. After GH-RH stimulation the peak of GH (mean \u00b1 <jats:sc>sem<\/jats:sc>) was in prepubertal subjects: 25.3 \u00b1 9.1 \u03bcg\/l in CSS, and 18.6 \u00b1 10.3 \u03bcg\/l in IGHD. In pubertal subjects GH peaks were 17.6 \u00b1 8.4 \u03bcg\/l in CSS and 15.6 \u00b1 3.8 \u03bcg\/l in children with IDP. No significant differences was found between basal plasma SLI levels in the four groups of subjects, being respectively (mean \u00b1 <jats:sc>sem<\/jats:sc>) 11.9 \u00b1 1.8 pg\/ml in prepubertal subjects with CSS, 9.6 \u00b1 2.6 pg\/ml in IGHD, 7.6 \u00b1 1.7 pg\/ml in pubertal children with CSS and 6.6 \u00b1 1.5 pg\/ml in children with IDP. However, in the 46 children, a significant (r = \u22120.524, <jats:italic>P<\/jats:italic> &lt; 0.001) negative correlation was found between the amplitude of the peak of serum GH after GH-RH injection, and the basal values of SLI. The results suggest a possible regulatory mechanism for circulating somatostatin on GH release after injection of GH-RH.<\/jats:p>","DOI":"10.1530\/acta.0.1130001","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T21:53:47Z","timestamp":1229378027000},"page":"1-4","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":1,"title":["Negative correlation between peripheral plasma somatostatin levels and GH responses to GH-RH stimulation tests in children"],"prefix":"10.1093","volume":"113","author":[{"given":"C.","family":"Liapi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. Evain","family":"Brion","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Argente","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Vaudry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Donnadieu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/113\/1\/acta_113_1_001.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/113\/1\/acta_113_1_001.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:27:33Z","timestamp":1676392053000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/113\/1\/1\/6764058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,9]]},"references-count":0,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.1130001","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,9]]}}}