{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T13:26:38Z","timestamp":1697203598666},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1987,1]]},"abstract":"<jats:p>Abstract. Plasma testosterone (T, nmol\/l) and dihydrotestosterone (DTH, nmol\/l) were measured in 54 children and young adults with male pseudohermaphroditism (46XY, no defect of steroid biosynthesis) 4 h after im injection of testosterone propionate (25 mg\/m<jats:sup>2<\/jats:sup>, group 1, N = 18), or before and 2, 4 and 6 days after hCG (5000 IU\/m<jats:sup>2<\/jats:sup> im, group 2, N = 36). The response to hCG was also studied in 5 control children (unilateral cryptorchidism, group 3) and that to testosterone propionate in a gonadectomized child with confirmed 5\u03b1-reductase deficiency. Mean T (133.1 \u00b1 14.0, <jats:sc>sem<\/jats:sc>) and DHT (17.1 \u00b1 2.6) in group 1 were higher than in group 2 (17.3 \u00b1 2.1 and 2.9 \u00b1 0.4), but there was not significant difference in the T\/DHT ratios (group 1: 10.7 \u00b1 2.0; group 2: 7.2 \u00b1 0.6). Following testosterone-propionate, there was a negative correlation of T with age (r = \u22120.723). After hCG, T and DHT were lower in the prepubertal children than in those under 2 or over 10 years, and the T\/DHT-ratio rose with age. Two children from group 1 had a T\/DHT-ratio above 18, but urinary aetiocholanolone\/androsterone (Ae\/A) ratios were normal. In the child with 5\u03b1-reductase deficiency, the T\/DHT ratio was 60, and the urinary Ae\/A ratio high. We concluded that the two tests are suitable for confirming or excluding 5\u03b1-reductase deficiency in prepubertal children, in whom basal DHT is too low for evaluation, but that physiological age-related changes in 5\u03b1-reductase activity have to be taken into consideration.<\/jats:p>","DOI":"10.1530\/acta.0.1140113","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T22:02:37Z","timestamp":1229378557000},"page":"113-117","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":10,"title":["Comparison of two tests to recognize or exclude 5\u03b1-reductase deficiency in prepubertal children"],"prefix":"10.1093","volume":"114","author":[{"given":"S.","family":"Greene","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Zachmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Manella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Hesse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Hoepffner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Willgerodt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Prader","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/114\/1\/acta_114_1_017.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/114\/1\/acta_114_1_017.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:28:25Z","timestamp":1676392105000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/114\/1\/113\/6764163"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,1]]},"references-count":0,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.1140113","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,1]]}}}