{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T00:08:19Z","timestamp":1697933299569},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1987,2]]},"abstract":"<jats:p>Abstract. We have examined the IgG subclass distribution of thyroglobulin (Tg) and microsomal (M) auto-antibodies in 31 patients with Graves' disease before and after treatment with carbimazole. IgG<jats:sub>1<\/jats:sub> and IgG<jats:sub>2<\/jats:sub> subclass antibodies were detected before treatment in nearly all patients, and in over a third there was an excess of activity in the IgG<jats:sub>3<\/jats:sub> and IgG<jats:sub>4<\/jats:sub> subclasses. There were significant differences between the IgG subclasses composing Tg antibodies (less IgG <jats:sub>1<\/jats:sub> and IgG<jats:sub>3<\/jats:sub> but more IgG<jats:sub>2<\/jats:sub> in the latter). Patients who were HLA-DR3-positive had significantly lower levels of IgG<jats:sub>4<\/jats:sub> in M antibodies than in those who were DR3-negative. A variety of changes were found after treatment, and these depended on whether the patient entered remission or relapse. In particular, IgG<jats:sup>1<\/jats:sup> levels of M antibodies were consistently higher in the relapse group, whereas after 1 year in remission IgG<jats:sub>4<\/jats:sub> levels fell, and IgG<jats:sub>2<\/jats:sub> levels rose. These results show preferential production of certain IgG subclasses composing thyroid autoantibodies in Graves' disease which appears to be associated with HLA-DR3 status and the response to antithyroid drugs.<\/jats:p>","DOI":"10.1530\/acta.0.1140292","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T22:02:37Z","timestamp":1229378557000},"page":"292-297","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":2,"title":["The relationship of HLA-DR3 and outcome after antithyroid drugs to the IgG subclass distribution of thyroid autoantibodies in Graves' disease"],"prefix":"10.1093","volume":"114","author":[{"given":"A. P.","family":"Weetman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shara B.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/114\/2\/acta_114_2_019.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/114\/2\/acta_114_2_019.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:28:34Z","timestamp":1676392114000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/114\/2\/292\/6764178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,2]]},"references-count":0,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.1140292","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,2]]}}}