{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T20:43:22Z","timestamp":1698180202078},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1987,4]]},"abstract":"<jats:p>Abstract. According to desired phenylalanine (Phe) levels of 50\u201380 mg\/l during treatment, three groups of patients with classical phenylketonuria (PKU) (5.3\u201317.1 years) were formed. They were investigated for their growth hormone (GH) and insulin response to arginine infusion: Group I (N = 5) had Phe levels below (22 \u00b1 4 mg\/l), group II (N = 3) within (61 \u00b1 6 mg\/l), and group III (N = 3) above therapeutic limits (156 \u00b1 3 mg\/l). Nine children (5.2\u201314.5 years) with short stature served as controls. Whereas group I and II PKU children showed normal GH response to arginine infusion, group III children exhibited impaired GH response expressed as integrated GH response (218 \u00b1 38.6 \u03bcg \u00b7 1<jats:sup>\u22121<\/jats:sup> \u00b7 2 h vs 911 \u00b1 145 \u03bcg \u00b7 1<jats:sup>\u22121<\/jats:sup>\u00b7 2 h; <jats:italic>P<\/jats:italic> &lt;0.01) or peak GH response (6.6 \u00b1 1.2 \u03bcg\/l vs 18.7 \u00b1 2.3 \u03bcg\/l; <jats:italic>P<\/jats:italic> &lt; 0.05). Integrated insulin responses did not differ between the three PKU groups but were significantly higher in all PKU patients compared with controls (4903 \u00b1 421 mU\/l vs 2750 \u00b1 378 mU\/l; <jats:italic>P<\/jats:italic> &lt; 0.01). However, this reflects impaired insulin secretion in children with constitutional delay of growth and adolescence rather than hyperinsulinism in PKU patients.<\/jats:p>","DOI":"10.1530\/acta.0.1140483","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T22:02:37Z","timestamp":1229378557000},"page":"483-487","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":1,"title":["Circulating serum phenylalanine concentrations and the effect of arginine infusion on plasma levels of growth hormone and insulin in treated phenylketonuric children"],"prefix":"10.1093","volume":"114","author":[{"given":"R.","family":"Rosskamp","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Mallmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Liappis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Soetadjii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/114\/4\/acta_114_4_004.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/114\/4\/acta_114_4_004.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:28:45Z","timestamp":1676392125000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/114\/4\/483\/6764158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,4]]},"references-count":0,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.1140483","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,4]]}}}