{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:24:48Z","timestamp":1760189088639},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"1_Suppl","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1987,8]]},"abstract":"<jats:p>Abstract. The review presents a concept for the pathogenesis of spontaneous, organ-specific autoimmune diseases that take into account an altered immune regulation, modulating hormonal influences and a genetically determined primary susceptibility of the target organ for the autoimmune attack. The concept is exemplified by means of the Obese strain (OS) chicken model which develops a spontaneous hereditary auto-immune thyroiditis. In repect to the the altered function of the immune system both, MHC associated (Ir) and non-MHC associated genes are involved. The MHC, i.e. a certain haplotype, only plays a modulatory role in determining the frequency and severity of spontaneous autoimmune thyroiditis, while the presence of certain non-MHC associated genes is a absolute prerequisite for the emergence of the disease. The latter is also true for the genetically determined target organ susce ptibility, while hormonal factors, notably sex-steroids and glucocorticoids, again only have a facultative, modulatory effect. Only if an appropriate genetic constellation concerning the non-MHC encoded aberrant immunological function and genes coding for the susceptibility of the thyroid gland for the autoimmune proces is present, severe autoimmune thyroids develops.<\/jats:p>","DOI":"10.1530\/acta.0.114s063","type":"journal-article","created":{"date-parts":[[2009,10,21]],"date-time":"2009-10-21T22:39:20Z","timestamp":1256164760000},"page":"S63-S69","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":2,"title":["Concept of a multigenic basis for the pathogenesis of spontaneous autoimmune thyroiditis"],"prefix":"10.1093","volume":"116","author":[{"given":"G.","family":"Wick","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/116\/1_Suppl\/acta_114_Suppl_281_008.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/116\/1_Suppl\/acta_114_Suppl_281_008.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:29:25Z","timestamp":1676392165000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/116\/1_Supplement\/S63\/6768672"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,8]]},"references-count":0,"journal-issue":{"issue":"1_Suppl"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.114s063","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,8]]}}}