{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T12:51:33Z","timestamp":1762865493867,"version":"build-2065373602"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1987,7]]},"abstract":"<jats:p>Abstract. Vitamin D metabolism was studied in the 'Hannover Pig', a strain which suffers from pseudo vitamin D-deficiency rickets, type I. Animals of this strain are known to be devoid of renal 25-hydroxyvitamin D<jats:sub>3<\/jats:sub>-1\u03b1-hydroxylase and -24-hydroxylase activities. Pigs with florid rickets and hypocalcaemia were treated with single im injections of 0.25 to 1.25 mg of vitamin D<jats:sub>3<\/jats:sub>, doses that have been shown in previous studies to be effective in producing transient healing of rachitic symptoms. The levels of vitamin D<jats:sub>3<\/jats:sub> and its most relevant physiological metabolites in plasma were estimated at intervals before and after this vitamin D<jats:sub>3<\/jats:sub> treatment. Vitamin D<jats:sub>3<\/jats:sub> rose from 14.8 \u00b1 8.1 to 364 \u00b1 190 nmol\/l (mean \u00b1 <jats:sc>sd<\/jats:sc>) 2 to 3 days post injectionem, 25-hydroxyvitamin D<jats:sub>3<\/jats:sub> from 131.0 \u00b1 46.2 to 1068 \u00b1 160 nmol\/l within 7 days post injectionem. The 1\u03b1,25-dihydroxyvitamin D<jats:sub>3<\/jats:sub> concentration in plasma was elevated from 73.9 \u00b1 25.0 to 281 \u00b1 168 pmol\/l 2 to 3 days post injectionem and declined continually from that time. 24R,25-dihydroxyvitamin D<jats:sub>3<\/jats:sub> and 25S,26-dihydroxyvitamin D<jats:sub>3<\/jats:sub> levels after treatment showed different responses in different animals being either elevated or unchanged. Clinical healing of the pigs with these doses of vitamin D<jats:sub>3<\/jats:sub> was attributed to the transient rise of 1\u03b1,25-dihydroxyvitamin D<jats:sub>3<\/jats:sub> in plasma. It was assumed that 1\u03b1,25-dihydroxyvitamin D<jats:sub>3<\/jats:sub> synthesis takes place under these circumstances in extrarenal tissues.<\/jats:p>","DOI":"10.1530\/acta.0.1150345","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T22:02:37Z","timestamp":1229378557000},"page":"345-352","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":6,"title":["Vitamin D3 metabolism in a pig strain with pseudo vitamin D-deficiency rickets, type I"],"prefix":"10.1093","volume":"115","author":[{"given":"Reinhard","family":"Kaune","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johein","family":"Harmeyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/115\/3\/acta_115_3_010.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/115\/3\/acta_115_3_010.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:30:55Z","timestamp":1676392255000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/115\/3\/345\/6764230"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,7]]},"references-count":0,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.1150345","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"type":"print","value":"0804-4643"},{"type":"electronic","value":"1479-683X"}],"subject":[],"published":{"date-parts":[[1987,7]]}}}