{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T05:24:17Z","timestamp":1676438657178},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1987,8]]},"abstract":"<jats:p>Abstract. The effects on prolactin secretion of histamine H<jats:sub>2<\/jats:sub>-receptor antagonists infused intracerebroventricularly were studied in urethane anaesthetized male rats. A dose of 1.6 \u03bcmol cimetidine stimulated basal prolactin secretion and did not affect the histamine-induced release, whereas 0.4 \u03bcmol cimetidine inhibited basal and histamine-stimulated prolactin secretion. 0.1 \u03bcmol cimetidine had no effect. The more potent H<jats:sub>2<\/jats:sub>-receptor antagonist ranitidine at doses of 0.1, 0.4, 1.6 \u03bcmol had no effect on basal prolactin secretion, whereas 0.4 and 1.6 \u03bcmol inhibited the histamine-stimulated secretion completely. SKF-92408, a compound resembling cimetidine in chemical structure but devoid of H<jats:sub>2<\/jats:sub>-receptor antagonist activity, stimulated basal prolactin secretion at a dose of 1.6 \u03bcmol, but had no effect on the histamine-induced release or at a dose of 0.4 \u03bcmol. The H<jats:sub>2<\/jats:sub>-receptor antagonists metiamide and oxmetidine (1.6 \u03bcmol) stimulated basal prolactin secretion and did not prevent the response to histamine. A dose of 0.4 or 1.6 \u03bcmol imidazole (the ring structure contained in cimetidine, SKF-92408, metiamide, and oxmetidine) had no effect on basal or histamine-stimulated prolactin secretion. The findings indicate that cimetidine stimulates prolactin secretion by a non-specific action when infused centrally at high doses. In contrast, when infused at lower doses cimetidine inhibits the basal and histamine-stimulated secretion by blockade of H<jats:sub>2<\/jats:sub>-receptors. The prolactin-stimulatory action of cimetidine was not due to an H<jats:sub>2<\/jats:sub>-agonist effect, since ranitidine did not prevent the response. Cimetidine did not stimulate prolactin secretion via an effect on the dopaminergic system, since the drug had no effect on the dopamine concentration in hypophysial portal blood or in hypothalamic tissue and since inhibition of the dopamine synthesis by \u03b1-methyl-p-tyrosine did not prevent the cimetidine-induced prolactin release.<\/jats:p>","DOI":"10.1530\/acta.0.1150461","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T22:02:37Z","timestamp":1229378557000},"page":"461-468","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":8,"title":["Effects of H2-receptor antagonists on prolactin secretion: Specificity and mediation of the response"],"prefix":"10.1093","volume":"115","author":[{"given":"Ulrich","family":"Knigge","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steen","family":"Matzen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f8rgen","family":"Warberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/115\/4\/acta_115_4_005.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/115\/4\/acta_115_4_005.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:31:00Z","timestamp":1676392260000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/115\/4\/461\/6653635"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,8]]},"references-count":0,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.1150461","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,8]]}}}