{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T04:49:43Z","timestamp":1696481383337},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1987,11]]},"abstract":"<jats:p>Abstract. Only partial studies evaluating the endocrine profile in molar pregnancy have been performed. In order to characterize the neuro-endocrine pattern during and after molar pregnancy, we studied the basal hormonal levels of hCG, human placental lactogen (hPL), FSH, GH, TSH, free thyroxine index (FTI), oestradiol-17\u03b2 (E<jats:sub>2<\/jats:sub>), and progesterone (PG), as well as the anterior pituitary response to TRH, GnRH, and hypoglycaemia induced by insulin in 7 patients during molar pregnancy and one week after molar abortion. hCG showed significantly higher serum levels during rather than after molar pregnancy and hPL was detectable in only 4 patients during, but in none after molar pregnancy. FSH values were in the follicular phase range before and after molar abortion (12.7 \u00b1 0.8 and 12.7 \u00b1 3.5 IU\/l). PRL had elevated basal levels before and after molar abortion; 103.0 \u00b1 16.5 and 43 \u00b1 10.6 \u03bcg\/l, respectively (<jats:italic>P<\/jats:italic> &lt; 0.05). GH levels were distinctly elevated in 3 patients during molar pregnancy; after molar abortion, the basal GH values were normal in all patients &lt; 10 \u03bcg\/l. Basal cortisol and TSH levels were in the normal range before and after molar abortion. The FTI was above the normal range in 3 patients during molar pregnancy, whereas after molar abortion the values were normalized. E<jats:sub>2<\/jats:sub> levels were elevated before and after molar abortion, 1881 \u00b1 477 and 96.5 \u00b1 39.2 ng\/l, respectively (<jats:italic>P<\/jats:italic> &lt; 0.01). PG levels before and after molar abortion were 30.9 \u00b1 5.4 and 10 \u00b1 6.7 \u03bcg\/l, respectively (<jats:italic>P<\/jats:italic> &lt; 0.05). Comparison of women with molar pregnancy vs women with normal pregnancy showed a significant difference only as to \u03b2 hCG (<jats:italic>P<\/jats:italic> &lt; 0.05), whereas comparison of women in molar puerperium vs women in normal puerperium after term pregnancy showed a significant difference in \u03b2 hCG (<jats:italic>P<\/jats:italic> &lt; 0.01), PRL (<jats:italic>P<\/jats:italic> &lt; 0.01), and PG (<jats:italic>P<\/jats:italic> &lt; 0.01). Six of the 7 patients had a PRL increase of over 100% of the basal level in the first 15 min after TRH administration; one week after molar abortion, all patients had a normal PRL response to TRH. During molar pregnancy, only 3 patients showed a normal TSH response to TRH, 4 patients did not respond; 3 of them had an FTI above normal range. During the second challenge one week after molar abortion, 5 patients showed a normal TSH response to TRH. The hypoglycaemia stimulus induced a normal cortisol and GH response in 6 and in 5 patients, respectively, during molar pregnancy; after molar abortion, all patients had a normal cortisol and GH response to hypoglycaemia. FSH had no response to GnRH during or after molar pregnancy. These results establish the neuro-endocrine pattern in patients with molar pregnancy showing a clear disturbance in the neuro-endocrine regulation of the thyroid axis as well as in the GH release.<\/jats:p>","DOI":"10.1530\/acta.0.1160373","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T22:02:37Z","timestamp":1229378557000},"page":"373-380","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":1,"title":["Neuroendocrine regulation of anterior pituitary function in patients during and after molar pregnancy"],"prefix":"10.1093","volume":"116","author":[{"given":"G.","family":"Forsbach","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Contreras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"de Hoyos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Martinez-Campos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/116\/3\/acta_116_3_009.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/116\/3\/acta_116_3_009.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:31:29Z","timestamp":1676392289000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/116\/3\/373\/6764306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,11]]},"references-count":0,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.1160373","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,11]]}}}