{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T22:13:36Z","timestamp":1758924816858},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1988,4]]},"abstract":"<jats:p>Abstract. Specific binding of <jats:sup>125<\/jats:sup>I-human epidermal growth factor (hEGF) to homogenates of term human placentas and fetal membranes from normal and appropriate for gestational age (N = 20), intrauterine growth retarded (N = 9), twin (N = 11), White class A\/B diabetic (N = 12), and large for gestational age (N = 13) pregnancies was measured. In all pregnancy states, placentas bound approximately four times more <jats:sup>125<\/jats:sup>I-hEGF than did fetal membranes (<jats:italic>P<\/jats:italic> &lt; 0.001). There was no significant difference in <jats:sup>125<\/jats:sup>I-hEGF binding to fetal membranes from the various pregnancy states (<jats:italic>P<\/jats:italic> &gt; 0.05). <jats:sup>125<\/jats:sup>I-hEGF specific binding to placentas from intrauterine growth retarded or twin pregnancies was significantly greater compared with placentas from normal and appropriate for gestational age pregnancies (<jats:italic>P<\/jats:italic> &lt; 0.05). The binding to placentas from pregnancies complicated by White class A\/B diabetes or large for gestational age infants, on the other hand, was not significantly different from that to placentas from normal and appropriate for gestational age pregnancies. <jats:sup>125<\/jats:sup>I-hEGF specific binding did not differ between placentas from intrauterine growth retarded or twin pregnancies (<jats:italic>P<\/jats:italic> &gt; 0.05). Placental and fetal membrane <jats:sup>125<\/jats:sup>I-hEGF binding did not vary with fetal sex, maternal race, placental weight, or gestational age between 37 to 42 weeks (<jats:italic>P<\/jats:italic> &gt; 0.05). Placental but not fetal membrane <jats:sup>125<\/jats:sup>I-hEGF binding increased with increasing infant weight when appropriate for gestational age and large for gestational age infants were included (<jats:italic>P<\/jats:italic> &lt; 0.05, r = 0.38, N = 32) but not for intrauterine growth retarded, appropriate for gestational age, or large for gestational age infants alone.<\/jats:p>","DOI":"10.1530\/acta.0.1170485","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T22:02:37Z","timestamp":1229378557000},"page":"485-490","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":4,"title":["125I-human epidermal growth factor specific binding to placentas and fetal membranes from various pregnancy states"],"prefix":"10.1093","volume":"117","author":[{"given":"Glen E.","family":"Hofmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ch. V.","family":"Rao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fred R.","family":"Carman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tariq A.","family":"Siddiqi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/117\/4\/acta_117_4_010.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/117\/4\/acta_117_4_010.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:32:06Z","timestamp":1676392326000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/117\/4\/485\/6772088"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,4]]},"references-count":0,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.1170485","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,4]]}}}