{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T05:24:01Z","timestamp":1676438641472},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1988,5]]},"abstract":"<jats:p>Abstract. To investigate the iodothyronine metabolism in non-thyroidal illness (NTI), thyroidectomized male Wistar rats bearing the hypercalcemic Walker sarcoma 256 were substituted with, respectively, 2.3 and 11.5 \u03bcmol T<jats:sub>4<\/jats:sub>\/100 g body weight by daily ip injection. Serum T<jats:sub>4<\/jats:sub> and T<jats:sub>3<\/jats:sub> concentrations of euthyroid and hyperthyroid tumor-bearing animals markedly decreased to a nadir at day 8 after tumor implantation: serum T<jats:sub>4<\/jats:sub> fell to, respectively, 43% (euthyroid) and 26% (hyperthyroid) of initial values, serum T<jats:sub>3<\/jats:sub> to 19% (euthyroid) and 26% (hyperthyroid). A measurable serum rT<jats:sub>3<\/jats:sub> concentration could not be detected before and after tumor implantation. In vitro deiodination of T<jats:sub>4<\/jats:sub> to T<jats:sub>3<\/jats:sub> in liver homogenates of the sacrificed animals was not significantly reduced in Walker rats compared with control animals. The activity of T<jats:sub>4<\/jats:sub> deiodinase was significantly induced in hyperthyroid controls (180%) as well as in hyperthyroid Walker rats (155%) in spite of low serum concentrations of T<jats:sub>4<\/jats:sub> and T<jats:sub>3<\/jats:sub>. This enzyme induction was even more pronounced in animals whose treatment with high T<jats:sub>4<\/jats:sub> doses was started after tumor implantation. In these rats the serum concentrations of free fatty acids were increased to about 200% of controls. Our data suggest that 1. the fluctuations of iodothyronine serum concentrations in NTI are mainly independent of thyroidal secretion, and 2. the intracellular iodothyronine levels in livers of severely sick animals with different thyroid function are not greatly altered by NTI, in spite of markedly decreased total serum levels.<\/jats:p>","DOI":"10.1530\/acta.0.1180031","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T22:02:37Z","timestamp":1229378557000},"page":"31-37","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":2,"title":["Iodothyronine deiodination in rats with severe non-thyroidal illness"],"prefix":"10.1093","volume":"118","author":[{"given":"M.","family":"Grussendorf","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Wollensack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"H\u00fcfner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/118\/1\/acta_118_1_004.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/118\/1\/acta_118_1_004.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:33:12Z","timestamp":1676392392000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/118\/1\/31\/6770285"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,5]]},"references-count":0,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.1180031","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,5]]}}}