{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T07:06:13Z","timestamp":1762067173639,"version":"build-2065373602"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1990,1]]},"abstract":"<jats:title>Abstract.<\/jats:title>\n<jats:p>Sera of 63 patients with Graves' disease, and 49 control subjects were assayed for T<jats:sub>3<\/jats:sub> autoantibodies by a sensitive radioimmunoassay after being stripped of the endogenous thyroid hormone. T<jats:sub>3<\/jats:sub> autoantibodies were demonstrated in 27% of patients with Graves' disease. After antithyroid treatment, T<jats:sub>3<\/jats:sub> autoantibodies in 75% of the patients with positive antibody before therapy changed to negative titre during a follow-up period of 1 to 12 months. Also, a significant decrease of T<jats:sub>3<\/jats:sub> autoantibodies was observed at 1 month after therapy in all patients who received antithyroid treatment. A further study of T<jats:sub>3<\/jats:sub> autoantibodies and anti-thyroglobulin antibodies showed that the latter were demonstrated in 100% of patients with positive T<jats:sub>3<\/jats:sub> autoantibodies and that T<jats:sub>3<\/jats:sub> autoantibodies existed in about one third of patients with positive anti-thyroglobulin antibodies. The results suggested that T<jats:sub>3<\/jats:sub> autoantibodies could be a subpopulation of the heterogenous anti-thyroglobulin antibodies. Although the fall of T<jats:sub>3<\/jats:sub> autoantibodies in some patients was correlated to that of anti-thyroglobulin antibodies, the overall correlation between T<jats:sub>3<\/jats:sub> autoantibodies and anti-thyroglobulin antibodies was poor. In conclusion: 1. T<jats:sub>3<\/jats:sub> autoantibodies may be suppressed by antithyroid drugs. 2. Being a subpopulation of anti-thyroglobulin antibodies, T<jats:sub>3<\/jats:sub> autoantibodies may be caused by an antigenic site within the big thyroglobulin molecule, whereas their titre was not correlated with that of the overall heterogenous anti-thyroglobulin antibodies.<\/jats:p>","DOI":"10.1530\/acta.0.1220022","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T22:02:37Z","timestamp":1229378557000},"page":"22-28","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":5,"title":["Triiodothyronine autoantibodies in Graves' disease: Their changes after antithyroid therapy and relationship with the thyroglobulin antibodies"],"prefix":"10.1093","volume":"122","author":[{"given":"Pei-Wen","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miau-Ju","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rue-Tsuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung Dar","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/122\/1\/acta_122_1_004.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/122\/1\/acta_122_1_004.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:10:58Z","timestamp":1676391058000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/122\/1\/22\/6771155"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,1]]},"references-count":0,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.1220022","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"type":"print","value":"0804-4643"},{"type":"electronic","value":"1479-683X"}],"subject":[],"published":{"date-parts":[[1990,1]]}}}