{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:36:55Z","timestamp":1761957415705,"version":"build-2065373602"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1991,8]]},"abstract":"<jats:title>Abstract.<\/jats:title>\n<jats:p>The effects of GH and T<jats:sub>4<\/jats:sub> substitution on peripheral iodothyronine deiodinase activity in the liver, kidney and brown adipose tissue of hypophysectomized rats were investigated. Animals were treated with GH (140 \u03bcg hGH\/day), T<jats:sub>4<\/jats:sub> (3 \u03bcg\/day), GH plus T<jats:sub>4<\/jats:sub> (same doses), or saline. Rats were killed 0, 4, 7 or 11 days after treatment was started. Non-hypophysectomized, age matched rats were killed after 0 and 11 days and served as controls. GH plus T<jats:sub>4<\/jats:sub> restored body weight gain to normal, whereas GH alone and T<jats:sub>4<\/jats:sub> alone did not. Tissue deiodinase activity and T<jats:sub>3<\/jats:sub> concentrations were severely depressed in the hypophysectomized rats compared with non-hypophysectomized controls (to less than 10%). GH substitution in hypophysectomized rats led to a slight but significant elevation in tissue iodothyronine deiodinase activity in the liver and kidney, without concomitant increases in T<jats:sub>3<\/jats:sub>. Deiodinase activity in brown adipose tissue did not differ from that in saline-treated controls. T<jats:sub>4<\/jats:sub> administration normalized deiodinase activity and tissue T<jats:sub>3<\/jats:sub> content in all the evaluated tissues. GH plus T<jats:sub>4<\/jats:sub> resulted in a lesser increase in deiodinase activity than T<jats:sub>4<\/jats:sub> alone in the liver and kidney (p&lt;0.01 at day 11), whereas no significant difference was observed in brown adipose tissue. In conclusion, GH stimulates iodothyronine deiodinase activity of the liver and kidney in hypophysectomized rats. Moreover, when GH is administered together with T<jats:sub>4<\/jats:sub>, the T<jats:sub>4<\/jats:sub>-stimulated enzyme activity in the liver and kidney is downregulated, suggesting that GH attenuates (or modulates) the T<jats:sub>4<\/jats:sub> effect on this specific enzyme activity.<\/jats:p>","DOI":"10.1530\/acta.0.1250219","type":"journal-article","created":{"date-parts":[[2009,6,11]],"date-time":"2009-06-11T17:28:10Z","timestamp":1244741290000},"page":"219-226","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":8,"title":["The influence of growth hormone and thyroxine on iodothyronine deiodinase activity in the liver, kidney and brown adipose tissue in hypophysectomized rats"],"prefix":"10.1093","volume":"125","author":[{"given":"Liv S. Bj\u00f8rn-Hansen","family":"G\u00f8tzsche","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allan","family":"Flyvbjerg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sally","family":"Marshall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin D.","family":"J\u00f8rgensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f8rgen","family":"Weeke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/125\/2\/acta_125_2_016.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/125\/2\/acta_125_2_016.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:13:27Z","timestamp":1676391207000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/125\/2\/219\/6769173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,8]]},"references-count":0,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.1250219","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"type":"print","value":"0804-4643"},{"type":"electronic","value":"1479-683X"}],"subject":[],"published":{"date-parts":[[1991,8]]}}}