{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T21:59:32Z","timestamp":1757541572342},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"5","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1992,11]]},"abstract":"<jats:p>In this study we examined the effect of the adenosine analogues: N<jats:sup>6<\/jats:sup>-cyclohexyladenosine, L-N<jats:sup>6<\/jats:sup>-phenylisopropyladenosine and 5\u2032-N-ethylcarboxamidoadenosine on the plasma corticosterone concentration in rats. It was found that N<jats:sup>6<\/jats:sup>-cyclohexyladenosine (0.1\u20133.0 mg\/kg), L-N<jats:sup>6<\/jats:sup>-phenylisopropyladenosine (0.1\u20131.0 mg\/kg) and 5\u2032-N-ethylcarboxamidoadenosine (0.01\u20131.0 mg\/kg) dose-dependently increased the plasma corticosterone level. The effects of N<jats:sup>6<\/jats:sup>-cyclohexyladenosine (0.1 mg\/kg) and L-N<jats:sup>6<\/jats:sup>-phenylisopropyladenosine (0.1 mg\/kg) were completely blocked in animals pretreated with dexamethasone (3 \u00d7 1 mg\/kg), as well as in animals with a pharmacological blockade of the release of hypothalamic corticotropin-releasing factor induced by chloropromazine (10 mg\/kg), morphine (20 mg\/kg) and nembutal (25 mg\/kg), whereas the corticosterone response to 5\u2032-N-ethylcarboxamidoadenosine (0.01 mg\/kg) was blocked in dexamethasone-pretreated rats only. On the other hand, the adenosine receptor antagonists: 8-(p-sulfophenyl)-theophylline (30 mg\/kg), 8-phenyltheophylline (10 and 30mg\/kg), 1,3-dipropyl-8-(2-amino-4-chloro)-phenylxanthine (1 and 3 mg\/kg) and 1,3-dipropyl-7-methylxanthine (1 mg\/kg) did not affect the corticosterone response to N<jats:sup>6<\/jats:sup>-cyclohexyladenosine, L-N<jats:sup>6<\/jats:sup>-phenylisopropyladenosine or 5\u2032-N-ethylcarboxamidoadenosine. The obtained results indicate that N<jats:sup>6<\/jats:sup>-cyclohexyladenosine and L-N<jats:sup>6<\/jats:sup>-phenylisopropyladenosine stimulate the corticosterone secretion at the hypothalamic level, whereas 5\u2032-N-ethylcarboxamidoadenosine is likely to act at the pituitary level. Although the effects produced by the adenosine analogues show that both A<jats:sub>1<\/jats:sub> and A<jats:sub>2<\/jats:sub> receptors are involved in the corticosterone response, negative results of the interaction studies with adenosine receptor antagonists indicate that further experiments are necessary to elucidate this problem.<\/jats:p>","DOI":"10.1530\/acta.0.1270471","type":"journal-article","created":{"date-parts":[[2009,6,11]],"date-time":"2009-06-11T17:28:10Z","timestamp":1244741290000},"page":"471-475","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":8,"title":["Effect of adenosine analogues on plasma corticosterone concentration in rats"],"prefix":"10.1093","volume":"127","author":[{"given":"Edmund","family":"Przegali\u0144ski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bogus\u0142awa","family":"Budziszewska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Grochmal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/127\/5\/acta_127_5_016.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/127\/5\/acta_127_5_016.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:15:18Z","timestamp":1676391318000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/127\/5\/471\/6769524"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,11]]},"references-count":0,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.1270471","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,11]]}}}