{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:04:53Z","timestamp":1761512693655},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1993,4]]},"abstract":"<jats:sec>\n<jats:title>Purpose:<\/jats:title>\n<jats:p>To assess the dynamics of the pituitary-ovarian axis in exaggerated thelarche, defined as premature thelarche associated with signs of systemic estrogen effects (advanced bone age and\/or growth acceleration) without progression to complete puberty. <jats:italic>Subjects and methods:<\/jats:italic> Seven girls (age &lt;2.5 years) with exaggerated thelarche, 6 girls with inactive pituitary-ovarian axis (premature adrenarche) and 21 girls with activated axis (central precocious puberty) had serum FSH, LH and E<jats:sub>2<\/jats:sub> measured serially before and 1 to 24 h after gonadotropin-releasing hormone agonist (GnRHa) administration (leuprolide, 20 \u03bcg\/kg sc), used as a test of combined pituitary-ovarian stimulation. <jats:italic>Results:<\/jats:italic> Although girls in the exaggerated thelarche and adrenarche group had similar [mean (SEM)] baseline FSH [3.2 (0.9) vs 1.4 (0.3) IU\/I], LH [0.36(0.1) vs 0.27 (0.02) IU\/I] and E<jats:sub>2<\/jats:sub> [20 (1.2) vs 21 (2) pmol\/l] concentrations, and similar peak post-GnRHa LH concentrations [5.5 (1.1) vs 2.4 (0.5) IU\/I], girls with exaggerated thelarche achieved higher peak FSH [41(9) vs 14 (3) IU\/I, p&lt; 0.01] and E<jats:sub>2<\/jats:sub> [243 (40) vs 37 (6) pmol\/l, p&lt;0.001] concentrations after GnRHa. In comparison to patients with exaggerated thelarche, girls with precocious puberty had higher (p&lt;0.01-0.001) baseline LH [3.6 (0.8) IU\/I], baseline E<jats:sub>2<\/jats:sub> [69 (11) pmol\/l], GnRHa-stimulated peak LH [68 (1 7) IU\/I] and peak E<jats:sub>2<\/jats:sub> [648 (58) pmol\/l] concentrations, but similar FSH parameters. <jats:italic>Conclusions:<\/jats:italic> Girls with exaggerated thelarche exhibit substantial E<jats:sub>2<\/jats:sub> secretory potential that can be demonstrated by GnRHa stimulation, is predominantly FSH-driven, and probably accounts for the manifestations of estrogen effect seen in these girls.<\/jats:p>\n<\/jats:sec>","DOI":"10.1530\/acta.0.1280345","type":"journal-article","created":{"date-parts":[[2009,6,11]],"date-time":"2009-06-11T17:28:10Z","timestamp":1244741290000},"page":"345-350","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":26,"title":["The pattern of gonadotropin and estradiol secretion in exaggerated thelarche"],"prefix":"10.1093","volume":"128","author":[{"given":"Luigi R","family":"Garibaldi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Aceto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colleen","family":"Weber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/128\/4\/acta_128_4_010.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/128\/4\/acta_128_4_010.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:15:44Z","timestamp":1676391344000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/128\/4\/345\/6769599"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,4]]},"references-count":0,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.1280345","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,4]]}}}