{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T17:22:32Z","timestamp":1715534552392},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1993,6]]},"abstract":"<jats:p>We present the characteristic features of mineralocorticoid receptor regulation in human mononuclear leukocytes in patients with diabetes mellitus. Eighteen diabetic patients (3M and 15F, aged from 28 to 77 years with a mean of 53\u00b114 (mean\u00b1<jats:sc>sd<\/jats:sc>) years) and 7 normal subjects (6M and IF, aged from 29 to 59 years with a mean of 41\u00b113 years) were studied. The mean plasma aldosterone concentration in the diabetic patients was significantly lower than that in the normal subjects (137\u00b162 vs 189\u00b136 pmol\/l, p&lt;0.05). Seven of the 18 diabetic patients were hypoaldosteronemic. These 7 patients, however, showed normokalemia, except one with mild hyperpotassemia. The number of binding sites of [<jats:sup>3<\/jats:sup>H]aldosterone to mineralocorticoid receptor in the diabetic patients was significantly higher than that in the normal subjects (853\u00b1281 vs 488\u00b1109 sites\/cell, p&lt;0.05), but there was no significant difference in K<jats:sub>d<\/jats:sub> of [<jats:sup>3<\/jats:sup>H]aldosterone binding to mineralocorticoid receptor between the diabetic patients and normal subjects (1.34\u00b10.37 vs 0.99\u00b10.61 nmol\/l). In the diabetic patients, a significant negative correlation was observed (r=0.70, p&lt;0.01) between plasma aldosterone concentration and the binding sites, but not between plasma aldosterone concentration and K<jats:sub>d<\/jats:sub>. In the total subjects, including normal subjects and diabetic patients, a significant negative correlation was also found between plasma aldosterone concentration and binding sites (r=0.72, p&lt;0.001). These results suggest that increased binding sites of mineralocorticoid receptor may help to prevent diabetic patients from being hyperkalemic.<\/jats:p>","DOI":"10.1530\/acta.0.1280529","type":"journal-article","created":{"date-parts":[[2009,6,11]],"date-time":"2009-06-11T17:28:10Z","timestamp":1244741290000},"page":"529-535","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":7,"title":["Aldosterone binding to mineralocorticoid receptors of mononuclear leukocytes in diabetic subjects"],"prefix":"10.1093","volume":"128","author":[{"given":"Takeshi","family":"Shimada","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keigo","family":"Yasuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Mori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiping","family":"Ni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leilani B","family":"Mercado-Asis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Murase","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyoshi","family":"Miura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/128\/6\/acta_128_6_008.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/128\/6\/acta_128_6_008.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:15:53Z","timestamp":1676391353000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/128\/6\/529\/6769636"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,6]]},"references-count":0,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.1280529","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,6]]}}}