{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:03:14Z","timestamp":1792587794383,"version":"4.5.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1993,8]]},"abstract":"<jats:p>Glomerular hyperfiltration is a characteristic feature of acromegaly but it is uncertain whether albuminuria is elevated in this disease. To investigate the role of abnormal growth hormone (GH) and insulin-like growth factor I (IGF-I) levels on urinary protein excretion, we measured the overnight urinary albumin excretion rate (UalbV) and creatinine clearance in 14 acromegalic patients with metabolically active disease (fasting GH &gt; 5 \u03bcg\/l and IGF-I &gt; 2.2 kU\/l), 8 GH-deficient patients and 20 control subjects. The UalbV was higher in the acromegalic patients (median 8.4 (range 4.2\u201368.2) \u03bcg\/min) than in the GH-deficient patients (2.0(0.9\u20135.9) \u03bcg\/min, p&lt; 0.001) and control subjects (3.3 (1.0\u2013 7.8) \u03bcg\/min, p &lt;0.01). Five acromegalic patients had UalbV levels above the normal upper normal limit of 10 \u03bcg\/min. Only one patient with concomitant untreated hypertension had persistent microalbuminuria. Creatinine clearance also was higher in the acromegalic patients (p&lt;0.05) and lower in the GH-deficient patients (p &lt;0.05) than in the control subjects. In 11 of these acromegalic cases, the lowering of GH by 63% and of IGF-I by 48%, following treatment with the somatostatin analogue (N = 10) or spontaneous pituitary infarction (N=1), reduced the UalbV by 29% to 4.9 (3.1\u201345.2) \u03bcg\/min (p&lt;0.01). Among the acromegalic patients (25 observations), the UalbV was related to GH (r=0.61, p&lt;0.01), IGF-I (r=0.57, p&lt;0.01) and creatinine clearance (r=0.54, p&lt;0.01). In conclusion, circulatory GH and IGF-I levels influence albuminuria. Because persistent microalbuminuria is uncommon in acromegaly, it is unlikely that GH elevation alone predisposes to clinically important glomerular damage.<\/jats:p>","DOI":"10.1530\/acta.0.1290151","type":"journal-article","created":{"date-parts":[[2009,6,11]],"date-time":"2009-06-11T17:28:10Z","timestamp":1244741290000},"page":"151-157","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":42,"title":["Effect of growth hormone and insulin-like growth factor I on urinary albumin excretion: studies in acromegaly and growth hormone deficiency"],"prefix":"10.1093","volume":"129","author":[{"given":"Klaas","family":"Hoogenberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim I","family":"Sluiter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin PF","family":"Dullaart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/129\/2\/acta_129_2_010.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/129\/2\/acta_129_2_010.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:16:06Z","timestamp":1676391366000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/129\/2\/151\/6769640"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,8]]},"references-count":0,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.1290151","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,8]]}}}