{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T21:28:59Z","timestamp":1785792539482,"version":"3.56.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"1","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["ec.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,7]]},"abstract":"\n Introduction\/background<\/jats:title>\n Vitamin D deficiency further increases circulating parathyroid hormone (PTH) levels in patients with primary hyperparathyroidism (pHPT), with potential detrimental effects on bone mass.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This was an observational clinical study in consecutive conservatively treated postmenopausal women (\n n<\/jats:italic>\n =40) with pHPT and coexistent 25-hydroxyvitamin D deficiency (25OHD \u226450\u200anmol\/l (\u226420\u200ang\/ml)). Patients who showed an increase in serum 25OHD above the threshold of vitamin D deficiency (>50\u200anmol\/l;\n n<\/jats:italic>\n =28) using treatment with various commonly prescribed vitamin D preparations were, for the purposes of statistical analyses, allocated to the treatment group. Patients who were retrospectively identified as having received no treatment with vitamin D and\/or remained vitamin D deficient were considered as non-responders\/controls (\n n<\/jats:italic>\n =12). Adjusted calcium (adjCa), PTH and 25OHD concentrations were monitored in all subjects up to 54 months (mean observation period of 18\u00b12 months).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Prolonged increased vitamin D intake, regardless of the source (serum 25OHD, increase from 32.2\u00b11.7\u200anmol\/l at baseline to 136.4\u00b111.6\u200anmol\/l,\n P<\/jats:italic>\n <0.0001), significantly reduced serum PTH (13.3\u00b11.1 vs 10.5\u00b11.0\u200apmol\/l,\n P<\/jats:italic>\n =0.0001), with no adverse effects on adjCa levels (2.60\u00b10.03 vs 2.60\u00b10.02\u200ammol\/l,\n P<\/jats:italic>\n =0.77) and renal function tests (\n P<\/jats:italic>\n >0.73). In contrast, serum PTH remained unchanged (15.8\u00b12.6 vs 16.3\u00b11.9\u200apmol\/l,\n P<\/jats:italic>\n =0.64) in patients who remained vitamin D deficient, with a significant difference between groups in changes of PTH (\n P<\/jats:italic>\n =0.0003). Intrapartial correlation analyses showed an independent negative correlation of changes in 25OHD with PTH levels (\n r<\/jats:italic>\n ic<\/jats:sub>\n =\u22120.41,\n P<\/jats:italic>\n =0.014).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Prolonged treatment with vitamin D in various commonly prescribed preparations appeared to be safe and significantly reduced PTH levels by 21%.<\/jats:p>\n <\/jats:sec>","DOI":"10.1530\/ec-12-0008","type":"journal-article","created":{"date-parts":[[2012,6,18]],"date-time":"2012-06-18T14:52:21Z","timestamp":1340031141000},"page":"13-21","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":17,"title":["Prolonged treatment with vitamin D in postmenopausal women with primary hyperparathyroidism"],"prefix":"10.1530","volume":"1","author":[{"given":"Ranganathan R","family":"Rao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harpal S","family":"Randeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sailesh","family":"Sankaranarayanan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murthy","family":"Narashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"M\u00f6hlig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisham","family":"Mehanna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin O","family":"Weickert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["ENDOCRINE CONNECTIONS"],"original-title":[],"link":[{"URL":"https:\/\/ec.bioscientifica.com\/view\/journals\/ec\/1\/1\/13.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ec.bioscientifica.com\/downloadpdf\/journals\/ec\/1\/1\/13.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:41:36Z","timestamp":1784554896000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/ec\/article\/1\/1\/13-21\/34463"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7]]},"references-count":0,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1530\/ec-12-0008","relation":{},"ISSN":["2049-3614"],"issn-type":[{"value":"2049-3614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7]]}}}