{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:16:29Z","timestamp":1784556989417,"version":"3.55.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"4","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/deed.en_GB"}],"content-domain":{"domain":["ec.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:p>\n                    This study examined the agreement between fingertip-capillary and antecubital-venous measures of appetite-related peptides. Simultaneous fingertip-capillary and antecubital-venous blood samples were collected from 19 participants. The samples were obtained at baseline, 30, 60, 90, and 120\u200amin following breakfast for the determination of plasma GLP1\n                    <jats:sub>7\u201336<\/jats:sub>\n                    , glucagon, insulin and leptin. Between-day reproducibility of fingertip-capillary-derived estimates was assessed in 18 participants. Deming regression, limits of agreement (LOA) and typical error as a coefficient of variation (CV) were used to quantify agreement (CV\n                    <jats:sub>a<\/jats:sub>\n                    ) and reproducibility (CV\n                    <jats:sub>r<\/jats:sub>\n                    ). Deming regression revealed no systematic bias for any of the analytes studied, but for insulin there was evidence of a proportional difference at higher concentrations. Measures of GLP1\n                    <jats:sub>7\u201336<\/jats:sub>\n                    (CV\n                    <jats:sub>a<\/jats:sub>\n                    =24.0%, LOA \u00b12.5\u200apg m\/l per h), leptin (CV\n                    <jats:sub>a<\/jats:sub>\n                    =9.0%, LOA \u00d7\/\u00f71.19) and glucagon (CV\n                    <jats:sub>a<\/jats:sub>\n                    =21.0%, LOA, \u00b131.5\u200apg m\/l per h) revealed good agreement between methodological approaches. Fingertip-capillary glucagon was highly reproducible between days (CV\n                    <jats:sub>r<\/jats:sub>\n                    =8.2%). GLP1\n                    <jats:sub>7\u201336<\/jats:sub>\n                    and leptin demonstrated modest reproducibility (CV\n                    <jats:sub>r<\/jats:sub>\n                    =22.7 and 25.0% respectively). For insulin, agreement (CV\n                    <jats:sub>a<\/jats:sub>\n                    =36.0%, LOA \u00d7\/\u00f71.79) and reproducibility were poor (CV\n                    <jats:sub>r<\/jats:sub>\n                    =36.0%). Collectively, the data demonstrate that fingertip-capillary blood sampling provides a comparable and reproducible alternative to antecubital-venous blood sampling for the quantification of glucagon, and to a lesser extent for GLP1\n                    <jats:sub>7\u201336<\/jats:sub>\n                    and leptin. Caution should be exercised when utilising fingertip-capillary blood sampling for insulin quantification, and consequently should not be employed interchangeably with antecubital-venous blood sampling.\n                  <\/jats:p>","DOI":"10.1530\/ec-14-0110","type":"journal-article","created":{"date-parts":[[2014,10,29]],"date-time":"2014-10-29T01:57:40Z","timestamp":1414547860000},"page":"233-242","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":10,"title":["Agreement between fingertip-capillary and antecubital-venous appetite-related peptides"],"prefix":"10.1530","volume":"3","author":[{"given":"Benjamin Paul","family":"Green","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier Thomas","family":"Gonzalez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Stevenson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penny Louise Sheena","family":"Rumbold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Endocrine Connections"],"original-title":[],"link":[{"URL":"https:\/\/ec.bioscientifica.com\/view\/journals\/ec\/3\/4\/233.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ec.bioscientifica.com\/downloadpdf\/journals\/ec\/3\/4\/233.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:41:51Z","timestamp":1784554911000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/ec\/article\/3\/4\/233-242\/35092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":0,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.1530\/ec-14-0110","relation":{},"ISSN":["2049-3614"],"issn-type":[{"value":"2049-3614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12]]}}}