{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:16:06Z","timestamp":1784556966103,"version":"3.55.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"2","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ec.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,3]]},"abstract":"\n Background<\/jats:title>\n Bilateral adrenal masses may have aetiologies like hyperplasia and infiltrative lesions, besides tumours. Hyperplastic and infiltrative lesions may have coexisting hypocortisolism. Bilateral tumours are likely to have hereditary\/syndromic associations. The data on clinical profile of bilateral adrenal masses are limited.<\/jats:p>\n <\/jats:sec>\n \n Aims<\/jats:title>\n To analyse clinical, biochemical and radiological features, and management outcomes in patients with bilateral adrenal masses.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Retrospective analysis of 70 patients with bilateral adrenal masses presenting to a single tertiary care endocrine centre from western India (2002\u20132015).<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The most common aetiology was pheochromocytoma (40%), followed by tuberculosis (27.1%), primary adrenal lymphoma (PAL) (10%), metastases (5.7%), non-functioning adenomas (4.3%), primary bilateral macronodular adrenal hyperplasia (4.3%), and others (8.6%). Age at presentation was less in patients with pheochromocytoma (33 years) and tuberculosis (41 years) compared with PAL (48 years) and metastases (61 years) (\n P<\/jats:italic>\n <0.001). The presenting symptoms for pheochromocytoma were hyperadrenergic spells (54%) and abdominal pain (29%), whereas tuberculosis presented with adrenal insufficiency (AI) (95%). The presenting symptoms for PAL were AI (57%) and abdominal pain (43%), whereas all cases of metastasis had abdominal pain. Mean size of adrenal masses was the largest in lymphoma (5.5cm) followed by pheochromocytoma (4.8cm), metastasis (4cm) and tuberculosis (2.1cm) (\n P<\/jats:italic>\n <0.001). Biochemically, most patients with pheochromocytoma (92.8%) had catecholamine excess. Hypocortisolism was common in tuberculosis (100%) and PAL (71.4%) and absent with metastases (\n P<\/jats:italic>\n <0.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n In evaluation of bilateral adrenal masses, age at presentation, presenting symptoms, lesion size, and biochemical features are helpful in delineating varied underlying aetiologies.<\/jats:p>\n <\/jats:sec>","DOI":"10.1530\/ec-16-0015","type":"journal-article","created":{"date-parts":[[2016,4,2]],"date-time":"2016-04-02T00:05:49Z","timestamp":1459555549000},"page":"92-100","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-2","source":"Crossref","is-referenced-by-count":27,"title":["Bilateral adrenal masses: a single-centre experience"],"prefix":"10.1530","volume":"5","author":[{"given":"Nilesh","family":"Lomte","sequence":"first","affiliation":[{"name":"Department of EndocrinologySeth G S Medical College, KEM Hospital, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tushar","family":"Bandgar","sequence":"additional","affiliation":[{"name":"Department of EndocrinologySeth G S Medical College, KEM Hospital, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shruti","family":"Khare","sequence":"additional","affiliation":[{"name":"Department of EndocrinologySeth G S Medical College, KEM Hospital, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swati","family":"Jadhav","sequence":"additional","affiliation":[{"name":"Department of EndocrinologySeth G S Medical College, KEM Hospital, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anurag","family":"Lila","sequence":"additional","affiliation":[{"name":"Department of EndocrinologySeth G S Medical College, KEM Hospital, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manjunath","family":"Goroshi","sequence":"additional","affiliation":[{"name":"Department of EndocrinologySeth G S Medical College, KEM Hospital, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajeev","family":"Kasaliwal","sequence":"additional","affiliation":[{"name":"Department of EndocrinologySeth G S Medical College, KEM Hospital, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kranti","family":"Khadilkar","sequence":"additional","affiliation":[{"name":"Department of EndocrinologySeth G S Medical College, KEM Hospital, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nalini S","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of EndocrinologySeth G S Medical College, KEM Hospital, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Endocrine Connections"],"original-title":[],"link":[{"URL":"https:\/\/ec.bioscientifica.com\/view\/journals\/ec\/5\/2\/92.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ec.bioscientifica.com\/downloadpdf\/journals\/ec\/5\/2\/92.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:42:02Z","timestamp":1784554922000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/ec\/article\/5\/2\/92-100\/35161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":0,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1530\/ec-16-0015","relation":{},"ISSN":["2049-3614"],"issn-type":[{"value":"2049-3614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3]]}}}