{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:16:49Z","timestamp":1784557009834,"version":"3.55.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"3","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ec.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,3]]},"abstract":"\n Human 3 beta-hydroxysteroid dehydrogenase deficiency (3b-HSD) is a very rare form of congenital adrenal hyperplasia resulting from\n HSD3B2<\/jats:italic>\n gene mutations. The estimated prevalence is less than 1\/1,000,000 at birth. It leads to steroidogenesis impairment in both adrenals and gonads. Few data are available concerning adult testicular function in such patients. We had the opportunity to study gonadal axis and testicular function in a 46,XY adult patient, carrying a\n HSD3B2<\/jats:italic>\n mutation. He presented at birth a neonatal salt-wasting syndrome. He had a micropenis, a perineal hypospadias and two intrascrotal testes.\n HSD3B2<\/jats:italic>\n gene sequencing revealed\n a<\/jats:italic>\n 687del27 homozygous mutation. The patient achieved normal puberty at the age of 15 years. Transition from the paediatric department occurred at the age of 19 years. His hormonal profile under hydrocortisone and fludrocortisone treatments revealed normal serum levels of 17OH-pregnenolone, as well as SDHEA, ACTH, total testosterone, inhibin B and AMH. Pelvic ultrasound identified two scrotal testes of 21\u2009mL each, without any testicular adrenal rest tumours. His adult spermatic characteristics were normal, according to WHO 2010 criteria, with a sperm concentration of 57.6\u2009million\/mL (\n N<\/jats:italic>\n \u2009>\u200915), 21% of typical forms (\n N<\/jats:italic>\n \u2009>\u20094%). Sperm vitality was subnormal (41%;\n N<\/jats:italic>\n \u2009>\u200958%). This patient, in contrast to previous reports, presents subnormal sperm parameters and therefore potential male fertility in a 24-years-old patient with severe 3b-HSD deficiency. This case should improve counselling about fertility of male patients carrying\n HSD3B2<\/jats:italic>\n mutation.\n <\/jats:p>","DOI":"10.1530\/ec-17-0306","type":"journal-article","created":{"date-parts":[[2018,2,8]],"date-time":"2018-02-08T04:46:17Z","timestamp":1518065177000},"page":"395-402","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-10","source":"Crossref","is-referenced-by-count":20,"title":["Human 3beta-hydroxysteroid dehydrogenase deficiency associated with normal spermatic numeration despite a severe enzyme deficit"],"prefix":"10.1530","volume":"7","author":[{"given":"Bruno","family":"Donadille","sequence":"first","affiliation":[{"name":"1Service d\u2019Endocrinologie et M\u00e9decine de la Reproduction, Centre de R\u00e9f\u00e9rence des Maladies Endocrines Rares de la Croissance, H\u00f4pital Saint Antoine, Groupe Hospitalier Universitaire Est, AP-HP, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muriel","family":"Houang","sequence":"additional","affiliation":[{"name":"2Service d\u2019Explorations Fonctionnelles Endocriniennes, Centre de R\u00e9f\u00e9rence des Maladies Endocrines Rares de la Croissance, H\u00f4pital Trousseau, Groupe Hospitalier Universitaire Est, AP-HP, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ir\u00e8ne","family":"Netchine","sequence":"additional","affiliation":[{"name":"2Service d\u2019Explorations Fonctionnelles Endocriniennes, Centre de R\u00e9f\u00e9rence des Maladies Endocrines Rares de la Croissance, H\u00f4pital Trousseau, Groupe Hospitalier Universitaire Est, AP-HP, Paris, France"},{"name":"3Universit\u00e9 Pierre et Marie Curie, Sorbonne Universit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Siffroi","sequence":"additional","affiliation":[{"name":"3Universit\u00e9 Pierre et Marie Curie, Sorbonne Universit\u00e9, Paris, France"},{"name":"4INSERM UMR_S933, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Christin-Maitre","sequence":"additional","affiliation":[{"name":"1Service d\u2019Endocrinologie et M\u00e9decine de la Reproduction, Centre de R\u00e9f\u00e9rence des Maladies Endocrines Rares de la Croissance, H\u00f4pital Saint Antoine, Groupe Hospitalier Universitaire Est, AP-HP, Paris, France"},{"name":"3Universit\u00e9 Pierre et Marie Curie, Sorbonne Universit\u00e9, Paris, France"},{"name":"4INSERM UMR_S933, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Endocrine Connections"],"original-title":[],"link":[{"URL":"https:\/\/ec.bioscientifica.com\/view\/journals\/ec\/7\/3\/EC-17-0306.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ec.bioscientifica.com\/downloadpdf\/journals\/ec\/7\/3\/EC-17-0306.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:42:37Z","timestamp":1784554957000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/ec\/article\/7\/3\/395-402\/286"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":0,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1530\/ec-17-0306","relation":{},"ISSN":["2049-3614"],"issn-type":[{"value":"2049-3614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3]]}}}