{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T17:18:29Z","timestamp":1785604709463,"version":"3.56.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"2","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ec.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,2]]},"abstract":"\n Goblet cell carcinomas (GCC) are a rare, aggressive sub-type of appendiceal tumours with neuroendocrine features, and controversy exists with regards to therapeutic strategy. We undertook a retrospective review of GCC patients surgically treated at two tertiary referral centres. Clinical and histopathological data were extracted from a prospectively maintained database. Survival analyses utilised Kaplan\u2013Meier methodology. Twenty-one patients were identified (9 females). Median age at diagnosis was 55 years (range 32\u201377). There were 3, 6 and 9 grade 1, 2 and 3 tumours, respectively. One, 10, 5 and 5 patients had stage I, II, III and IV disease at diagnosis, respectively. There were 8, 10 and 3 Tang class A, B and C tumours, respectively. Index operation was appendectomy (\n n<\/jats:italic>\n \u2009=\u200912), right hemicolectomy (\n n<\/jats:italic>\n \u2009=\u20096) or resections including appendix\/right colon, omentum and the gynaecological system (\n n<\/jats:italic>\n \u2009=\u20093). Eight patients underwent completion right hemicolectomy. Surgery for recurrence included small bowel resection (\n n<\/jats:italic>\n \u2009=\u20092), debulking with peritonectomy and heated intraperitoneal chemotherapy, and hysterectomy and bilateral salpingo-oophorectomy (all\n n<\/jats:italic>\n \u2009=\u20091). Median follow-up was 30 months (range 2.5\u2013123). One-, 3- and 5-year OS was 79.4, 60 and 60%, respectively. Mean OS (1-, 3-, and 5-year OS) for Tang class A, B and C tumours were 73.1 months (85.7, 85.7, 51.4%), 83.7 months (all 66.7%) and 28.5 months (66.7, 66.7%, not reached), respectively. Chromogranin A\/B and\n 68<\/jats:sup>\n Ga-DOTATATE PET\/CT were not useful in follow-up, but CEA, CA 19-9, CA 125 and\n 18<\/jats:sup>\n F-FDG PET\/CT identified tumour recurrence. GCC must be clearly discriminated from relatively indolent appendiceal neuroendocrine neoplasms.\n 18<\/jats:sup>\n F-FDG PET\/CT and CEA\/CA19-9\/CA 125 are useful in detecting recurrence of GCC.\n <\/jats:p>","DOI":"10.1530\/ec-17-0311","type":"journal-article","created":{"date-parts":[[2018,1,15]],"date-time":"2018-01-15T20:20:15Z","timestamp":1516047615000},"page":"268-277","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-10","source":"Crossref","is-referenced-by-count":36,"title":["Goblet cell carcinomas of the appendix: rare but aggressive neoplasms with challenging management"],"prefix":"10.1530","volume":"7","author":[{"given":"Ashley K","family":"Clift","sequence":"first","affiliation":[{"name":"1Department of Surgery and Cancer, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oskar","family":"Kornasiewicz","sequence":"additional","affiliation":[{"name":"1Department of Surgery and Cancer, Imperial College London, London, UK"},{"name":"2Department of Surgery, Warsaw Medical University, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Drymousis","sequence":"additional","affiliation":[{"name":"1Department of Surgery and Cancer, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Faiz","sequence":"additional","affiliation":[{"name":"3Department of Surgery, St Mark\u2019s Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harpreet S","family":"Wasan","sequence":"additional","affiliation":[{"name":"1Department of Surgery and Cancer, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M","family":"Kinross","sequence":"additional","affiliation":[{"name":"1Department of Surgery and Cancer, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Cecil","sequence":"additional","affiliation":[{"name":"4Peritoneal Malignancy Unit, Basingstoke and North Hampshire Hospital, Basingstoke, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Frilling","sequence":"additional","affiliation":[{"name":"1Department of Surgery and Cancer, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Endocrine Connections"],"original-title":[],"link":[{"URL":"https:\/\/ec.bioscientifica.com\/view\/journals\/ec\/7\/2\/EC-17-0311.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ec.bioscientifica.com\/downloadpdf\/journals\/ec\/7\/2\/EC-17-0311.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:42:38Z","timestamp":1784554958000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/ec\/article\/7\/2\/268-277\/275"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":0,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1530\/ec-17-0311","relation":{},"ISSN":["2049-3614"],"issn-type":[{"value":"2049-3614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2]]}}}