{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:16:49Z","timestamp":1784557009137,"version":"3.55.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"2","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ec.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Diagnostic re-evaluation is important for all patients with congenital hypothyroidism (CH) for determining the etiology and identifying transient CH cases. Our study is a first thyroxine therapy withdrawal study conducted in Macedonian CH patients for a diagnostic re-evaluation. We aimed to evaluate the etiology of CH, the prevalence of transient CH and identify predictive factors for distinguishing between permanent (PCH) and transient CH (TCH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>Patients with CH aged &gt;3 years underwent a trial of treatment withdrawal for 4 weeks period. Thyroid function testing (TFT), ultrasound and Technetium-99m pertechnetate thyroid scan were performed thereafter. TCH was defined when TFT remained within normal limits for at least 6-month follow-up. PCH was diagnosed when TFT was abnormal and classified according the imaging findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      42 (55%) patients had PCH and 34 (45.0%) patients had TCH. Thyroid agenesia was the most prevalent form in the PCH group. Patients with TCH had lower initial thyroid-stimulating hormone (TSH) values (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.0001); higher serum thyroxine levels (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.0023) and lower mean doses of levothyroxine during treatment period (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.0001) than patients with PCH. Initial TSH level &lt;30.5\u2009IU\/mL and levothyroxine dose at 3 years of age &lt;2.6\u2009mg\/kg\/day were a significant predictive factors for TCH; sensitivity 92% and 100%, specificity 75.6% and 76%, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>TCH presents a significant portion of patients with CH. Initial TSH value and levothyroxine dose during treatment period has a predictive role in differentiating TCH from PCH. Earlier re-evaluation, between 2 and 3 years age might be considered in some patients requiring low doses of levothyroxine.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/ec-17-0332","type":"journal-article","created":{"date-parts":[[2018,1,15]],"date-time":"2018-01-15T20:20:15Z","timestamp":1516047615000},"page":"278-285","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-10","source":"Crossref","is-referenced-by-count":33,"title":["Diagnostic re-evaluation of congenital hypothyroidism in Macedonia: predictors for transient or permanent hypothyroidism"],"prefix":"10.1530","volume":"7","author":[{"given":"Nikolina","family":"Zdraveska","sequence":"first","affiliation":[{"name":"1University Children\u2019s Hospital Skopje, Faculty of Medicine, Skopje, Republic of Macedonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maja","family":"Zdravkovska","sequence":"additional","affiliation":[{"name":"2Institute of Patophysiology and Nuclear Medicine, Faculty of Medicine, Skopje, Republic of Macedonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Violeta","family":"Anastasovska","sequence":"additional","affiliation":[{"name":"1University Children\u2019s Hospital Skopje, Faculty of Medicine, Skopje, Republic of Macedonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Sukarova-Angelovska","sequence":"additional","affiliation":[{"name":"1University Children\u2019s Hospital Skopje, Faculty of Medicine, Skopje, Republic of Macedonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjana","family":"Kocova","sequence":"additional","affiliation":[{"name":"1University Children\u2019s Hospital Skopje, Faculty of Medicine, Skopje, Republic of Macedonia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Endocrine Connections"],"original-title":[],"link":[{"URL":"https:\/\/ec.bioscientifica.com\/view\/journals\/ec\/7\/2\/EC-17-0332.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ec.bioscientifica.com\/downloadpdf\/journals\/ec\/7\/2\/EC-17-0332.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:42:40Z","timestamp":1784554960000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/ec\/article\/7\/2\/278-285\/272"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":0,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1530\/ec-17-0332","relation":{},"ISSN":["2049-3614"],"issn-type":[{"value":"2049-3614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2]]}}}