{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:16:49Z","timestamp":1784557009084,"version":"3.55.0"},"reference-count":86,"publisher":"Bioscientifica","issue":"6","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ec.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:p>Myeloid-related protein 14 (MRP14) is responsible for inflammatory reactions. However, the correlation between MRP14 and Hashimoto\u2019s thyroiditis (HT) is still not clear. In this study, we examined the status of MRP14 in thyroid tissues and sera of HT patients and explored the mechanism of IL-1\u03b2-mediated regulation of MRP14 expression, as well as the effects of MRP14 on pro-inflammatory chemokine secretion in thyroid follicular cells (TFCs), to elucidate the role of MRP14 in HT development. Our results showed dramatically increased MRP14 expression in thyroid tissues and sera from HT patients. In addition, IL-1\u03b2 significantly promoted the expression of MRP14 in TFCs, which was mediated by activation of the MAPK\/NF-\u03baB signalling pathway. More importantly, IL-1\u03b2 induced the secretion of the chemokines GRO-2, CXCL9 and CCL22, which was dependent on the regulation of MRP14 in TFCs. Therefore, these findings suggested that under pro-inflammatory conditions, TFCs secreted chemokines with the help of MRP14 regulation, which might suggest a potential pathological mechanism of lymphocyte infiltration into the thyroid gland in HT.<\/jats:p>","DOI":"10.1530\/ec-18-0019","type":"journal-article","created":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T16:08:05Z","timestamp":1526400485000},"page":"850-858","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-10","source":"Crossref","is-referenced-by-count":14,"title":["Aberrant MRP14 expression in thyroid follicular cells mediates chemokine secretion through the IL-1\u03b2\/MAPK pathway in Hashimoto\u2019s thyroiditis"],"prefix":"10.1530","volume":"7","author":[{"given":"Xuan","family":"Luo","sequence":"first","affiliation":[{"name":"1Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Zheng","sequence":"additional","affiliation":[{"name":"1Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoming","family":"Mao","sequence":"additional","affiliation":[{"name":"1Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, China"},{"name":"2Institute of Oncology, The Affiliated Hospital of Jiangsu University, Zhenjiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Dong","sequence":"additional","affiliation":[{"name":"1Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Mou","sequence":"additional","affiliation":[{"name":"1Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengcheng","family":"Xu","sequence":"additional","affiliation":[{"name":"1Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyan","family":"Lu","sequence":"additional","affiliation":[{"name":"1Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baocui","family":"Liu","sequence":"additional","affiliation":[{"name":"1Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengjun","family":"Wang","sequence":"additional","affiliation":[{"name":"3Department of Laboratory Immunology, Jiangsu University School of Medicine, Zhenjiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichuan","family":"Xiao","sequence":"additional","affiliation":[{"name":"4Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"ref421","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1084\/jem.20050640","article-title":"Blocking IL-1 in systemic inflammation","volume":"201","year":"2005","journal-title":"Journal of Experimental Medicine"},{"key":"ref571","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3109\/08916939108994704","article-title":"Interleukin-6 production by thyroid epithelial cells. 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