{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:13:25Z","timestamp":1787022805991,"version":"build-2736575974"},"reference-count":0,"publisher":"Bioscientifica","issue":"3","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["ec.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,3]]},"abstract":"\n Context<\/jats:title>\n Bilateral inferior petrosal sinus sampling (BIPSS) using hCRH is currently considered the \u2018gold standard\u2019 test for the differential diagnosis of ACTH-dependent Cushing\u2019s syndrome (CS). Vasopressin is more potent than CRH to stimulate ACTH secretion as shown in animal studies; however, no comparative data of its use are available during BIPSS.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To study the diagnostic accuracy and comparison of hCRH and lysine vasopressin (LVP) stimulation during BIPSS.<\/jats:p>\n <\/jats:sec>\n \n Patients and methods<\/jats:title>\n 29 patients (27-Cushing\u2019s disease, 2-ectopic CS; confirmed on histopathology) underwent BIPSS and were included for the study. Patients were randomized to receive hCRH, 5\u2009U LVP or 10\u2009U LVP during BIPSS for ACTH stimulation. BIPSS and contrast-enhanced magnetic resonance imaging (CEMRI) were compared with intra-operative findings of trans-sphenoidal surgery (TSS) for localization and lateralization of the ACTH source.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n BIPSS correctly localized the source of ACTH excess in 29\/29 of the patients with accuracy of 26\/26 patients, using any of the agent, whereas sensitivity and PPV for lateralization with hCRH, 5\u2009U LVP and 10\u2009U LVP was seen in 10\/10, 6\/10; 10\/10,8\/10 and 7\/7,6\/7 patients respectively. Concordance of BIPSS with TSS was seen in 20\/27, CEMRI with BIPSS in 16\/24 and CEMRI with TSS in 18\/24 of patients for lateralizing the adenoma. Most of the side effects were transient and were comparable in all the three groups.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n BIPSS using either hCRH or LVP (5\u2009U or 10\u2009U) confirmed the source of ACTH excess in all the patients, while 10\u2009U LVP correctly lateralized the pituitary adenoma in three fourth of the patients.<\/jats:p>\n <\/jats:sec>","DOI":"10.1530\/ec-18-0046","type":"journal-article","created":{"date-parts":[[2018,2,13]],"date-time":"2018-02-13T12:06:41Z","timestamp":1518523601000},"page":"425-432","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-10","source":"Crossref","is-referenced-by-count":21,"title":["Diagnostic accuracy and comparison of BIPSS in response to lysine vasopressin and hCRH"],"prefix":"10.1530","volume":"7","author":[{"given":"Kush Dev Singh","family":"Jarial","sequence":"first","affiliation":[{"name":"1Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil","family":"Bhansali","sequence":"additional","affiliation":[{"name":"1Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Gupta","sequence":"additional","affiliation":[{"name":"2Department of Radio-diagnosis, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paramjeet","family":"Singh","sequence":"additional","affiliation":[{"name":"2Department of Radio-diagnosis, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanchan K","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"3Department of Neurosurgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akhilesh","family":"Sharma","sequence":"additional","affiliation":[{"name":"4Department of Psychiatry, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh K","family":"Vashishtha","sequence":"additional","affiliation":[{"name":"5Department of Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suja P","family":"Sukumar","sequence":"additional","affiliation":[{"name":"1Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naresh","family":"Sachdeva","sequence":"additional","affiliation":[{"name":"1Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rama","family":"Walia","sequence":"additional","affiliation":[{"name":"1Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Endocrine Connections"],"original-title":[],"link":[{"URL":"https:\/\/ec.bioscientifica.com\/view\/journals\/ec\/7\/3\/EC-18-0046.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ec.bioscientifica.com\/downloadpdf\/journals\/ec\/7\/3\/EC-18-0046.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:42:46Z","timestamp":1784554966000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/ec\/article\/7\/3\/425-432\/274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":0,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1530\/ec-18-0046","relation":{},"ISSN":["2049-3614"],"issn-type":[{"value":"2049-3614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3]]}}}