{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:16:17Z","timestamp":1784556977314,"version":"3.55.0"},"reference-count":66,"publisher":"Bioscientifica","issue":"9","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ec.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:p>The significance of the presence of androgen receptor (AR), estrogen receptor alpha (ER) and progesterone receptor (PR) in ovarian cancer patient survival has been a matter of numerous studies. This study was aimed to describe the expression profile of the three sexual steroid receptors in high-grade serous, endometrioid, mucinous and low-grade serous ovarian carcinoma and its association to the proliferation index in patients with primary ovarian carcinoma diagnosis, before any treatment. Eighty-one samples were obtained from the National Institute of Cancerology in Mexico City and were evaluated for the presence of AR, ER, PR and Ki67 by immunohistochemistry. The four subtypes of ovarian carcinoma displays a specific profile of the eight possible combinations of the steroid receptors with significant differences within the profile and the histological subtypes. High-grade serous carcinoma was characterized by a high frequency of both, triple-negative and AR+ ER\u2212 PR+ profiles. Endometrioid carcinoma presented a higher frequency of triple-positive profile. The presence of only AR+ profile was not observed in the endometrioid tumors. The relationship of the receptor profile with the proliferation index in the tumor epithelium shows that the expression of only ER is associated to a reduced proliferation index in endometrioid carcinoma. Steroid hormone receptor expression and co-expression could help characterize ovarian carcinoma.<\/jats:p>","DOI":"10.1530\/ec-18-0158","type":"journal-article","created":{"date-parts":[[2018,7,16]],"date-time":"2018-07-16T10:25:21Z","timestamp":1531736721000},"page":"1006-1012","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-10","source":"Crossref","is-referenced-by-count":14,"title":["Sexual steroid hormone receptors profiles of ovarian carcinoma in Mexican women"],"prefix":"10.1530","volume":"7","author":[{"given":"Mar\u00eda J","family":"G\u00f3mora","sequence":"first","affiliation":[{"name":"1Departamento de Embriolog\u00eda, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, CdMx, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia","family":"Morales-V\u00e1squez","sequence":"additional","affiliation":[{"name":"2Departamento de Oncolog\u00eda M\u00e9dica, Instituto Nacional de Cancerolog\u00eda, Secretar\u00eda de Salud de M\u00e9xico, CdMx, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Pedernera","sequence":"additional","affiliation":[{"name":"1Departamento de Embriolog\u00eda, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, CdMx, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delia","family":"Perez-Montiel","sequence":"additional","affiliation":[{"name":"3Departamento de Patolog\u00eda, Instituto Nacional de Cancerolog\u00eda, Secretar\u00eda de Salud de M\u00e9xico, CdMx, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horacio","family":"L\u00f3pez-Basave","sequence":"additional","affiliation":[{"name":"4Departamento de Cirug\u00eda Oncol\u00f3gica, Instituto Nacional de Cancerolog\u00eda, Secretar\u00eda de Salud de M\u00e9xico, CdMx, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio R","family":"Villa","sequence":"additional","affiliation":[{"name":"5Divisi\u00f3n de Investigaci\u00f3n, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, CdMx, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azucena","family":"Hern\u00e1ndez-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"6Hospital Militar de Especialidades de la Mujer y Neonatolog\u00eda, Secretar\u00eda de la Defensa Nacional, CdMx, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esteban","family":"Mena","sequence":"additional","affiliation":[{"name":"7Unidad de Apoyo Acad\u00e9mico, Secretar\u00eda General, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, CdMx, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Mendez","sequence":"additional","affiliation":[{"name":"1Departamento de Embriolog\u00eda, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de 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