{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:17:04Z","timestamp":1784557024457,"version":"3.55.0"},"reference-count":40,"publisher":"Bioscientifica","issue":"12","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ec.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,12]]},"abstract":"\n Objective<\/jats:title>\n Autoimmune thyroiditis (AIT) is the most common autoimmune thyroid disease. Longitudinal relaxation time mapping (T1-mapping) measured by MRI is a new technique for assessing interstitial fibrosis of some organs, such as heart and liver. This study aimed to evaluate the relationship between T1-mapping value and thyroid function and determine the usefulness of T1-mapping in identifying thyroid destruction in AIT patients.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This case\u2013control study recruited 57 drug-na\u00efve AIT patients and 17 healthy controls. All participants were given thyroid MRI, and T1-mapping values were measured using a modified look-locker inversion-recovery sequence.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n AIT patients had significantly higher thyroid T1-mapping values than the healthy controls (1.077\u2009\u00b1\u2009177 vs 778\u2009\u00b1\u200982.9\u2009ms;\n P<\/jats:italic>\n \u2009<\u20090.01). A significant increase in thyroid T1-mapping values was presented along with the increased severity of thyroid dysfunction (\n P<\/jats:italic>\n \u2009<\u20090.01). Correlation analyses showed that increased thyroid T1-mapping values were associated with higher TSH and lower FT3 and FT4 levels (TSH:\n r<\/jats:italic>\n \u2009=\u20090.75; FT3:\n r<\/jats:italic>\n \u2009=\u2009\u22120.47; FT4:\n r<\/jats:italic>\n \u2009=\u2009\u22120.72; all\n P<\/jats:italic>\n \u2009<\u20090.01). Receiver-operating characteristic curve analysis revealed a high diagnostic value of T1-mapping values for the degree of thyroid destruction (area under the curve was 0.95, 95% CI: 0.90\u20130.99,\n P<\/jats:italic>\n \u2009<\u20090.01).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n AIT patients have higher thyroid T1-mapping values than the healthy controls, and the T1-mapping values increased with the progression of thyroid dysfunction. Thyroid T1-mapping value might be a new index to quantitatively evaluate the degree of thyroid destruction in AIT patients.<\/jats:p>\n <\/jats:sec>","DOI":"10.1530\/ec-18-0175","type":"journal-article","created":{"date-parts":[[2018,8,17]],"date-time":"2018-08-17T07:54:22Z","timestamp":1534492462000},"page":"1315-1321","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-10","source":"Crossref","is-referenced-by-count":3,"title":["Magnetic resonance T1-mapping evaluates the degree of thyroid destruction in patients with autoimmune thyroiditis"],"prefix":"10.1530","volume":"7","author":[{"given":"Jia","family":"Liu","sequence":"first","affiliation":[{"name":"1Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Liu","sequence":"additional","affiliation":[{"name":"2Department of Radiology, China-Japan Friendship Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Chen","sequence":"additional","affiliation":[{"name":"1Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumei","family":"Jia","sequence":"additional","affiliation":[{"name":"1Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang","family":"Wang","sequence":"additional","affiliation":[{"name":"1Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"ref141","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/mrm.20110","article-title":"Modified Look-Locker inversion recovery (MOLLI) for high-resolution T1 mapping of the 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