{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T03:07:08Z","timestamp":1789787228390,"version":"4.0.1"},"reference-count":64,"publisher":"Bioscientifica","issue":"8","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["ec.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,8]]},"abstract":"\n Context<\/jats:title>\n Mild primary hyperparathyroidism has been associated with increased body fat mass and unfavorable cardiovascular risk factors.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To assess the effect of parathyroidectomy on fat mass, glucose and lipid metabolism.<\/jats:p>\n <\/jats:sec>\n \n Design, patients, interventions, main outcome measures<\/jats:title>\n \n 119 patients previously randomized to observation (OBS;\n n<\/jats:italic>\n \u2009=\u200958) or parathyroidectomy (PTX;\n n<\/jats:italic>\n \u2009=\u200961) within the Scandinavian Investigation of Primary Hyperparathyroidism (SIPH) trial, an open randomized multicenter study, were included. Main outcome measures for this study were the differences in fat mass, markers for lipid and glucose metabolism between OBS and PTX 5 years after randomization.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In the OBS group, total cholesterol (Total-C) decreased from mean 5.9 (\u00b11.1) to 5.6 (\u00b11.0)\u2009mmol\/L (\n P<\/jats:italic>\n \u2009=\u20090.037) and LDL cholesterol (LDL-C) decreased from 3.7 (\u00b11.0) to 3.3 (\u00b10.9)\u2009mmol\/L (\n P<\/jats:italic>\n \u2009=\u20090.010). In the PTX group, the Total-C and LDL-C remained unchanged resulting in a significant between-group difference over time (\n P<\/jats:italic>\n \u2009=\u20090.013 and\n P<\/jats:italic>\n \u2009=\u20090.026, respectively). This difference was driven by patients who started with lipid-lowering medication during the study period (OBS: 5; PTX: 1). There was an increase in trunk fat mass in the OBS group, but no between-group differences over time. Mean 25(OH) vitamin D increased in the PTX group (\n P<\/jats:italic>\n \u2009<\u20090.001), but did not change in the OBS group. No difference in parameters of glucose metabolism was detected.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n In mild PHPT, the measured metabolic and cardiovascular risk factors were not modified by PTX. Observation seems safe and cardiovascular risk reduction should not be regarded as a separate indication for parathyroidectomy based on the results from this study.<\/jats:p>\n <\/jats:sec>","DOI":"10.1530\/ec-18-0259","type":"journal-article","created":{"date-parts":[[2018,7,16]],"date-time":"2018-07-16T10:25:21Z","timestamp":1531736721000},"page":"941-948","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-10","source":"Crossref","is-referenced-by-count":29,"title":["The effect of surgery on fat mass, lipid and glucose metabolism in mild primary hyperparathyroidism"],"prefix":"10.1530","volume":"7","author":[{"given":"Kristin","family":"Godang","sequence":"first","affiliation":[{"name":"1Section of Specialized Endocrinology, Oslo University Hospital, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Lundstam","sequence":"additional","affiliation":[{"name":"2Department of Radiology, Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Mollerup","sequence":"additional","affiliation":[{"name":"3Clinic of Breast and Endocrine Surgery, Center HOC, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stine Lyngvi","family":"Fougner","sequence":"additional","affiliation":[{"name":"4Department of Endocrinology, St. Olavs Hospital, Trondheim, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ylva","family":"Pernow","sequence":"additional","affiliation":[{"name":"5Departments of Molecular Medicine, Surgery and Endocrinology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rgen","family":"Nordenstr\u00f6m","sequence":"additional","affiliation":[{"name":"6Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thord","family":"Ros\u00e9n","sequence":"additional","affiliation":[{"name":"7Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svante","family":"Jansson","sequence":"additional","affiliation":[{"name":"8Department of Endocrine Surgery, Sahlgrenska University Hospital, Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Hellstr\u00f6m","sequence":"additional","affiliation":[{"name":"2Department of Radiology, Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Bollerslev","sequence":"additional","affiliation":[{"name":"1Section of Specialized Endocrinology, Oslo University Hospital, Oslo, Norway"},{"name":"9Faculty of Medicine, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ansgar","family":"Heck","sequence":"additional","affiliation":[{"name":"1Section of Specialized Endocrinology, Oslo University Hospital, Oslo, Norway"},{"name":"9Faculty of Medicine, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"_","family":"_","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"ref171","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1210\/jc.2006-1836","article-title":"Medical observation, compared with parathyroidectomy, for asymptomatic primary hyperparathyroidism: a 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