{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:16:25Z","timestamp":1784556985643,"version":"3.55.0"},"reference-count":100,"publisher":"Bioscientifica","issue":"9","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ec.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Increased oxidative stress has been described in patients with Hashimoto\u2019s thyroiditis (HT). The aim of the present study was to investigate whether high oxidative stress is further influenced by obesity and dietary habits in euthyroid women with HT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Two hundred eighteen consecutive euthyroid women with HT were studied and separated in two groups; 102 with thyroxine replacement and 114 without. For the evaluation of oxidative stress, total lipid peroxide levels in serum (TOS) were measured and recoded as \u2018high TOS\u2019 vs \u2018medium\/low TOS\u2019. The type of food and consumption frequency were recorded. Two binary variables were considered; normal vs low fruit consumption and daily vs sporadic vegetable consumption.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\u2018High TOS\u2019 was more frequent in women under thyroxine replacement (31.4% vs 14.7%, OR\u2009=\u20092.7, 95% CI: 1.4\u20135.2). The prevalence of \u2018high TOS\u2019 was higher among overweight\/obese women compared to women with normal BMI (30.4% vs 12.5%, OR\u2009=\u20093.1, 95% CI: 1.5\u20136.4). Low fruit consumption was associated with increased \u2018high TOS\u2019 prevalence (30.6% vs 12.9%, OR\u2009=\u20093.0, 95% CI: 1.4\u20136.2). Sporadic vegetable consumption was associated with increased \u2018high TOS\u2019 prevalence compared to daily consumption (29.9% vs 13.5%, OR\u2009=\u20092.7, 95% CI: 1.3\u20135.7). The examined risk factors were independent and additive in their effect on TOS. At least three risk factors had to be concomitantly present for the likelihood of \u2018high TOS\u2019 to be significantly elevated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Oxidative stress is increased in women with HT under thyroxine replacement. Nevertheless, normal BMI, daily fruit and vegetable consumption, all contribute in maintaining oxidative stress at low levels.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/ec-18-0272","type":"journal-article","created":{"date-parts":[[2018,10,5]],"date-time":"2018-10-05T09:21:45Z","timestamp":1538731305000},"page":"990-997","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-10","source":"Crossref","is-referenced-by-count":32,"title":["The effect of obesity and dietary habits on oxidative stress in Hashimoto\u2019s thyroiditis"],"prefix":"10.1530","volume":"7","author":[{"given":"Maria","family":"Giannakou","sequence":"first","affiliation":[{"name":"1Endocrine Unit, Department Med Therapeutics, Alexandra Hospital, School of Medicine, National Kapodistrian University, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katerina","family":"Saltiki","sequence":"additional","affiliation":[{"name":"1Endocrine Unit, Department Med Therapeutics, Alexandra Hospital, School of Medicine, National Kapodistrian University, Athens, Greece"},{"name":"2Department of Endocrinology and Metabolism, Athens University School of Medicine, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Mantzou","sequence":"additional","affiliation":[{"name":"2Department of Endocrinology and Metabolism, Athens University School of Medicine, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Loukari","sequence":"additional","affiliation":[{"name":"2Department of Endocrinology and Metabolism, Athens University School of Medicine, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Philippou","sequence":"additional","affiliation":[{"name":"2Department of Endocrinology and Metabolism, Athens University School of Medicine, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Terzidis","sequence":"additional","affiliation":[{"name":"2Department of Endocrinology and Metabolism, Athens University School of Medicine, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charalampos","family":"Stavrianos","sequence":"additional","affiliation":[{"name":"2Department of Endocrinology and Metabolism, Athens University School of Medicine, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miltiades","family":"Kyprianou","sequence":"additional","affiliation":[{"name":"1Endocrine Unit, Department Med Therapeutics, Alexandra Hospital, School of Medicine, National Kapodistrian University, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodora","family":"Psaltopoulou","sequence":"additional","affiliation":[{"name":"3Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National Kapodistrian University, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalliopi","family":"Karatzi","sequence":"additional","affiliation":[{"name":"4Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Alevizaki","sequence":"additional","affiliation":[{"name":"1Endocrine Unit, Department Med Therapeutics, Alexandra Hospital, School of Medicine, National Kapodistrian University, Athens, Greece"},{"name":"2Department of Endocrinology and Metabolism, Athens University School of Medicine, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"ref311","first-page":"1004","article-title":"The effect of hypothyroidism, hyperthyroidism, and their treatment on parameters of oxidative stress and antioxidant 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