{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T02:19:32Z","timestamp":1789697972350,"version":"4.0.1"},"reference-count":62,"publisher":"Bioscientifica","issue":"12","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ec.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the safety and efficacy of letrozole in girls with progressive precocious puberty (PP) associated with McCune\u2013Albright syndrome (MAS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Monocentric retrospective cross-sectional and longitudinal study of consecutive patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients<\/jats:title>\n                    <jats:p>Ten MAS patients treated at Peking Union Medical College Hospital between September 1999 and December 2017 were retrospectively reviewed; those with complications due to PP were followed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean age at letrozole initiation was 4.5\u2009\u00b1\u20092.6 years, while the mean duration of treatment was 3.3\u2009\u00b1\u20092.4 years. Letrozole was highly effective at decreasing the rate of skeletal maturation, with a significant decrease in the bone age-to-chronological age (BA\/CA) ratio from 1.9\u2009\u00b1\u20091.1 pre-treatment to 1.5\u2009\u00b1\u20091.2 on letrozole treatment (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.016). Moreover, growth velocity\n                      <jats:italic>Z<\/jats:italic>\n                      -scores declined from 0.41\u2009\u00b1\u20090.5 to \u22120.2\u2009\u00b1\u20090.31 with treatment (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). Predicted adult height\n                      <jats:italic>Z<\/jats:italic>\n                      -scores increased significantly from \u22122.03\u2009\u00b1\u20092.33 at baseline to 1.13\u2009\u00b1\u20090.84 following treatment initiation (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.029). Moreover, vaginal bleeding declined significantly on letrozole.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings suggest that letrozole may be an effective therapy in some girls with MAS, as treatment results in improved BA\/CA ratio, growth velocity and predicted adult height. Possible adverse effects include nettle rash.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/ec-18-0344","type":"journal-article","created":{"date-parts":[[2018,11,22]],"date-time":"2018-11-22T09:39:51Z","timestamp":1542879591000},"page":"1424-1431","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-10","source":"Crossref","is-referenced-by-count":12,"title":["Management of precocious puberty in girls with McCune\u2013Albright syndrome using letrozole"],"prefix":"10.1530","volume":"7","author":[{"given":"Xi","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Peking Union Medical College Hospital, Peking Union Medical 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testotoxicosis","volume":"20","year":"2007","journal-title":"Journal of Pediatric Endocrinology and Metabolism"},{"key":"ref131","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0022-3476(52)80205-7","article-title":"Tables for predicting adult height from skeletal age: revised for use with the Greulich\u2013Pyle hand standards","volume":"40","year":"1952","journal-title":"Journal of Pediatrics"},{"key":"ref231","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1089\/thy.1997.7.433","article-title":"Hyperthyroidism in McCune\u2013Albright syndrome with a review of thyroid abnormalities sixty years after the first report","volume":"7","year":"1997","journal-title":"Thyroid"},{"key":"ref321","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1056\/NEJM199112123252403","article-title":"Activating mutations of the stimulatory G protein in the McCune\u2013Albright syndrome","volume":"325","year":"1991","journal-title":"New England Journal of 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Zhi"},{"key":"ref171","doi-asserted-by":"crossref","first-page":"5730","DOI":"10.1210\/jc.2003-030864","article-title":"Lack of efficacy of fadrozole in treating precocious puberty in girls with the McCune\u2013Albright syndrome","volume":"88","year":"2003","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref291","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/s13023-016-0496-x","article-title":"Clinical and endocrine characteristics and genetic analysis of Korean children with McCune\u2013Albright syndrome: a retrospective cohort study","volume":"11","year":"2016","journal-title":"Orphanet Journal of Rare Diseases"},{"key":"ref451","first-page":"419","article-title":"Treatment of precocius puberty in McCune\u2013Albright syndrome","volume":"4","year":"2007","journal-title":"Pediatric Endocrinology Reviews"},{"key":"ref431","volume-title":"Atlas of Ultrasound Measurements","year":"2006"},{"key":"ref461","first-page":"607","article-title":"McCune\u2013Albright syndrome: persistence of autonomous ovarian hyperfunction During adolesance and early adult age","volume":"19","year":"2006","journal-title":"Endocrinology and Metabolism"},{"key":"ref381","first-page":"647","article-title":"Long-term testolactone therapy for precocious puberty in girls with the McCune\u2013Albright syndrome","volume":"77","year":"1993","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref371","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1203\/00006450-198609000-00010","article-title":"Ovarian function in girls with McCune\u2013Albright syndrome","volume":"20","year":"1986","journal-title":"Pediatric Research"},{"key":"ref211","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1530\/EJE-16-0526","article-title":"Long-term outcomes of letrozole treatment for precocious puberty in girls with McCune\u2013Albright 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England Journal of Medicine"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"5730","DOI":"10.1210\/jc.2003-030864","article-title":"Lack of efficacy of fadrozole in treating precocious puberty in girls with the McCune\u2013Albright syndrome","volume":"88","year":"2003","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref391","doi-asserted-by":"crossref","first-page":"5730","DOI":"10.1210\/jc.2003-030864","article-title":"Lack of efficacy of fadrozole in treating precocious puberty in girls with the McCune\u2013Albright syndrome","volume":"88","year":"2003","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref521","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1530\/EJE-16-0526","article-title":"Long-term outcomes of letrozole treatment for precocious puberty in girls with McCune\u2013Albright syndrome","volume":"175","year":"2016","journal-title":"European Journal of Endocrinology"},{"key":"ref361","first-page":"653","article-title":"An update on the treatment of precocious puberty in McCune\u2013Albright syndrome and testotoxicosis","volume":"20","year":"2007","journal-title":"Journal of Pediatric Endocrinology and Metabolism"},{"key":"ref341","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.pedn.2015.06.009","article-title":"McCune\u2013Albright syndrome: an overview of clinical features","volume":"30","year":"2015","journal-title":"Journal of Pediatric Nursing"},{"key":"ref01","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1750-1172-3-12","article-title":"McCune\u2013Albright syndrome","volume":"3","year":"2008","journal-title":"Orphanet Journal of Rare Diseases"},{"key":"ref501","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.1210\/jc.2007-2090","article-title":"The aromatase inhibitor anastrozole is ineffective in the treatment of precociouspuberty in girls with McCune\u2013Albright 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