{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T15:35:06Z","timestamp":1790091306325,"version":"4.0.1"},"reference-count":46,"publisher":"Bioscientifica","issue":"3","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ec.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Accumulating data have shown that interleukin-27 (\n                      <jats:italic>IL27<\/jats:italic>\n                      ) polymorphisms are linked to the susceptibility of some autoimmune diseases. We assessed whether there was an association between three single-nucleotide polymorphisms (SNPs) of\n                      <jats:italic>IL27<\/jats:italic>\n                      gene and autoimmune thyroid diseases (AITDs).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Three SNPs (rs153109, rs17855750 and rs181206) of\n                      <jats:italic>IL27<\/jats:italic>\n                      gene were genotyped by Hi-SNP high-throughput genotyping in 843 patients with AITDs (516 Graves\u2019 disease (GD) and 327 Hashimoto\u2019s thyroiditis (HT)) and 677 healthy controls in Chinese Han population.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with controls, rs153109 displayed significant associations with GD in allele and genotype frequencies (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.002 and\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.008, respectively) and rs17855750 displayed significant associations with HT in allele frequencies (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.02), whereas no differences in genotype or allele frequencies were found between AITD patients and controls at rs181206.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Our study, for the first time, showed the significant association of the\n                      <jats:italic>IL27<\/jats:italic>\n                      gene SNPs with AITD.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/ec-18-0370","type":"journal-article","created":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T10:17:24Z","timestamp":1548757044000},"page":"173-181","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-10","source":"Crossref","is-referenced-by-count":17,"title":["Association of single-nucleotide polymorphisms in the IL27 gene with autoimmune thyroid diseases"],"prefix":"10.1530","volume":"8","author":[{"given":"Weiwei","family":"He","sequence":"first","affiliation":[{"name":"1Department of Endocrinology, Affiliated Hospital of Yanan Medical University, Shaanxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Wang","sequence":"additional","affiliation":[{"name":"2Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaida","family":"Mu","sequence":"additional","affiliation":[{"name":"3Department of Endocrinology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"3Department of Endocrinology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Yang","sequence":"additional","affiliation":[{"name":"3Department of Endocrinology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yao","sequence":"additional","affiliation":[{"name":"3Department of Endocrinology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheli","family":"Li","sequence":"additional","affiliation":[{"name":"1Department of Endocrinology, Affiliated Hospital of Yanan Medical University, Shaanxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-an","family":"Zhang","sequence":"additional","affiliation":[{"name":"3Department of Endocrinology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"ref61","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1146\/annurev-pathol-012513-104713","article-title":"Mechanisms of autoimmune thyroid diseases: from genetics to epigenetics","volume":"9","year":"2014","journal-title":"Annual Review of 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