{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:13:26Z","timestamp":1787022806251,"version":"build-2736575974"},"reference-count":86,"publisher":"Bioscientifica","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ec.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p>\n                    The avian pineal gland, an independent circadian oscillator, receives external photic cues and translates them for the rhythmical synthesis of melatonin. Our previous study found that monochromatic green light could increase the secretion of melatonin and expression of\n                    <jats:italic>CLOCK<\/jats:italic>\n                    and\n                    <jats:italic>BMAL1<\/jats:italic>\n                    in chick pinealocytes. This study further investigated the role of\n                    <jats:italic>BMAL1<\/jats:italic>\n                    and\n                    <jats:italic>CLOCK<\/jats:italic>\n                    in monochromatic green light-induced melatonin secretion in chick pinealocytes using siRNAs interference and overexpression techniques. The results showed that si-\n                    <jats:italic>BMAL1<\/jats:italic>\n                    destroyed the circadian rhythms of\n                    <jats:italic>AANAT<\/jats:italic>\n                    and melatonin, along with the disruption of the expression of all the seven clock genes, except\n                    <jats:italic>CRY1<\/jats:italic>\n                    . Furthermore, overexpression of\n                    <jats:italic>BMAL1<\/jats:italic>\n                    also disturbed the circadian rhythms of\n                    <jats:italic>AANAT<\/jats:italic>\n                    and melatonin, in addition to causing arrhythmic expression of\n                    <jats:italic>BMAL1<\/jats:italic>\n                    and\n                    <jats:italic>CRY1\/2<\/jats:italic>\n                    , but had no effect on the circadian rhythms of\n                    <jats:italic>CLOCK<\/jats:italic>\n                    ,\n                    <jats:italic>BMAL2<\/jats:italic>\n                    and\n                    <jats:italic>PER2\/3<\/jats:italic>\n                    . The knockdown or overexpression of\n                    <jats:italic>CLOCK<\/jats:italic>\n                    had no impact on the circadian rhythms of\n                    <jats:italic>AANAT<\/jats:italic>\n                    , melatonin,\n                    <jats:italic>BMAL1<\/jats:italic>\n                    and\n                    <jats:italic>PER2<\/jats:italic>\n                    , but it significantly deregulated the circadian rhythms of\n                    <jats:italic>CLOCK<\/jats:italic>\n                    ,\n                    <jats:italic>BMAL2<\/jats:italic>\n                    ,\n                    <jats:italic>CRY1\/2<\/jats:italic>\n                    and\n                    <jats:italic>PER3<\/jats:italic>\n                    . These results suggested that\n                    <jats:italic>BMAL1<\/jats:italic>\n                    rather than\n                    <jats:italic>CLOCK<\/jats:italic>\n                    plays a critical role in the regulation of monochromatic green light-induced melatonin rhythm synthesis in chicken pinealocytes. Moreover, both knockdown and overexpression of\n                    <jats:italic>BMAL1<\/jats:italic>\n                    could change the expression levels of\n                    <jats:italic>CRY2<\/jats:italic>\n                    , it indicated\n                    <jats:italic>CRY2<\/jats:italic>\n                    may be involved in the\n                    <jats:italic>BMAL1<\/jats:italic>\n                    pathway by modulating the circadian rhythms of\n                    <jats:italic>AANAT<\/jats:italic>\n                    and melatonin.\n                  <\/jats:p>","DOI":"10.1530\/ec-18-0377","type":"journal-article","created":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T13:53:45Z","timestamp":1544450025000},"page":"57-68","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-10","source":"Crossref","is-referenced-by-count":24,"title":["BMAL1 but not CLOCK is associated with monochromatic green light-induced circadian rhythm of melatonin in chick pinealocytes"],"prefix":"10.1530","volume":"8","author":[{"given":"Shuhui","family":"Ma","sequence":"first","affiliation":[{"name":"Laboratory of Anatomy of Domestic Animals, College of Animal Medicine, China Agricultural University, Haidian, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixu","family":"Wang","sequence":"additional","affiliation":[{"name":"Laboratory of Anatomy of Domestic Animals, College of Animal Medicine, China Agricultural University, Haidian, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Cao","sequence":"additional","affiliation":[{"name":"Laboratory of Anatomy of Domestic Animals, College of Animal Medicine, China Agricultural University, Haidian, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulan","family":"Dong","sequence":"additional","affiliation":[{"name":"Laboratory of Anatomy of Domestic Animals, College of Animal Medicine, China Agricultural University, Haidian, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaoxing","family":"Chen","sequence":"additional","affiliation":[{"name":"Laboratory of Anatomy of Domestic Animals, College of Animal Medicine, China Agricultural University, Haidian, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"ref51","first-page":"615","article-title":"Effects of physiological cycles of infused melatonin on circadian rhythmicity in pigeons","volume":"170","year":"1992","journal-title":"Journal of Comparative Physiology A Sensory"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1126\/science.174.4006.311","article-title":"Pineal function in sparrows: circadian rhythms and body 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