{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:16:38Z","timestamp":1784556998782,"version":"3.55.0"},"reference-count":46,"publisher":"Bioscientifica","issue":"5","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ec.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,5]]},"abstract":"\n Context<\/jats:title>\n Differentiated thyroid cancer (DTC) is usually treated by thyroidectomy followed by radioiodine ablation and generally has a good prognosis. It may now be possible to limit the amount of treatment without impacting on efficacy. It is not known whether coexistent thyroiditis impacts on radioiodine uptake or on its potential efficacy, but this could provide a rationale for modification to current therapeutic protocols.<\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n This was a retrospective cohort study of radioiodine uptake on imaging after radioiodine ablation for DTC in patients with and without concurrent thyroiditis. All patients with histologically confirmed DTC treated with radioiodine ablation after thyroidectomy in a single centre from 2012 to 2015 were included. The primary outcome assessed was the presence of low or no iodine uptake on post-ablation scan, as reported by a nuclear medicine physician blinded to the presence or absence of thyroiditis.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n One hundred thirty patients with available histopathology results were included. Thyroiditis was identified in 42 post-operative specimens and 15 of these patients had low or no iodine uptake on post-ablation scan, compared to only 2 of 88 patients without thyroiditis (\n P<\/jats:italic>\n \u2009<\u20090.0001) with further data analysis dividing the groups by ablation activity received (1100\u2009MBq or 3000\u2009MBq).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Concurrent thyroiditis may impair the uptake of radioactive iodine in management of DTC. Given that patients with DTC and thyroiditis already have a good prognosis, adopting a more selective approach to this step in therapy may be indicated. Large, longitudinal studies would be required to determine if omitting radioactive iodine therapy from those patients with concurrent thyroiditis has a measurable impact on mortality from thyroid cancer.<\/jats:p>\n <\/jats:sec>","DOI":"10.1530\/ec-19-0053","type":"journal-article","created":{"date-parts":[[2019,4,9]],"date-time":"2019-04-09T15:43:36Z","timestamp":1554824616000},"page":"571-578","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-10","source":"Crossref","is-referenced-by-count":3,"title":["Impact of thyroiditis on 131I uptake during ablative therapy for differentiated thyroid cancer"],"prefix":"10.1530","volume":"8","author":[{"given":"Eugenie S","family":"Lim","sequence":"first","affiliation":[{"name":"1Barts Health NHS Trust, Barts and the London School of Medicine and Dentistry, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanty G","family":"Shah","sequence":"additional","affiliation":[{"name":"2Barts and the London School of Medicine and Dentistry, QMUL, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona","family":"Waterhouse","sequence":"additional","affiliation":[{"name":"1Barts Health NHS Trust, Barts and the London School of Medicine and Dentistry, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Akker","sequence":"additional","affiliation":[{"name":"1Barts Health NHS Trust, Barts and the London School of Medicine and Dentistry, London, UK"},{"name":"2Barts and the London School of Medicine and Dentistry, QMUL, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Drake","sequence":"additional","affiliation":[{"name":"1Barts Health NHS Trust, Barts and the London School of Medicine and Dentistry, London, UK"},{"name":"2Barts and the London School of Medicine and Dentistry, QMUL, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick","family":"Plowman","sequence":"additional","affiliation":[{"name":"1Barts Health NHS Trust, Barts and the London School of Medicine and Dentistry, London, UK"},{"name":"2Barts and the London School of Medicine and Dentistry, QMUL, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel M","family":"Berney","sequence":"additional","affiliation":[{"name":"1Barts Health NHS Trust, Barts and the London School of Medicine and Dentistry, London, UK"},{"name":"2Barts and the London School of Medicine and Dentistry, QMUL, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Polly","family":"Richards","sequence":"additional","affiliation":[{"name":"1Barts Health NHS Trust, Barts and the London School of Medicine and Dentistry, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok","family":"Adams","sequence":"additional","affiliation":[{"name":"1Barts Health NHS Trust, Barts and the London School of Medicine and Dentistry, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Nowosinska","sequence":"additional","affiliation":[{"name":"1Barts Health NHS Trust, Barts and the London School of Medicine and Dentistry, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmel","family":"Brennan","sequence":"additional","affiliation":[{"name":"1Barts Health NHS Trust, Barts and the London School of Medicine and Dentistry, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maralyn","family":"Druce","sequence":"additional","affiliation":[{"name":"1Barts Health NHS Trust, Barts and the London School of Medicine and Dentistry, London, UK"},{"name":"2Barts and the London School of Medicine and Dentistry, QMUL, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"ref391","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1053\/j.seminoncol.2010.10.008","article-title":"Differentiated thyroid cancer","volume":"37","year":"2010","journal-title":"Seminars in Oncology"},{"key":"ref431","first-page":"4683","article-title":"Coexistence of chronic lymphocytic thyroiditis is associated with lower recurrence rates in patients with papillary thyroid carcinoma","volume":"93","year":"2009","journal-title":"Clinical Endocrinology"},{"key":"ref261","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/cen.12515","article-title":"British Thyroid Association. 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outcome","volume":"27","year":"2012","journal-title":"Journal of Korean Medical Science"},{"key":"ref371","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1177\/0194599812472426","article-title":"Hashimoto\u2019s thyroiditis as a risk factor of papillary thyroid cancer may improve cancer prognosis","volume":"148","year":"2013","journal-title":"Otolaryngology: Head and Neck Surgery"},{"key":"ref221","doi-asserted-by":"crossref","first-page":"4493","DOI":"10.1210\/endo.138.10.5571","article-title":"Iodine uptake and experimental 131I therapy in transplanted undifferentiated thyroid cancer cells expressing the Na+\/I- symporter gene","volume":"138","year":"1997","journal-title":"Endocrinology"},{"key":"ref11","first-page":"646","article-title":"The changing incidence of thyroid cancer","volume":"12","year":"2016","journal-title":"Nature Reviews: 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substances","year":"2000","journal-title":"Endotext"},{"key":"ref301","first-page":"618985","article-title":"Differentiated thyroid cancer: management of patients with radioiodine nonresponsive disease","volume":"2012","year":"2012","journal-title":"Journal of Thyroid Research"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1210\/jcem.85.1.6310","article-title":"Is diagnostic iodine-131 scanning useful after total thyroid ablation for differentiated thyroid cancer?","volume":"85","year":"2000","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref351","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.bjorl.2014.04.006","article-title":"Papillary thyroid carcinoma: does the association with Hashimoto\u2019s thyroiditis affect the clinicopathological characteristics of the disease?","volume":"81","year":"2015","journal-title":"Brazilian Journal of Otorhinolaryngology"},{"key":"ref441","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1089\/thy.1997.7.273","article-title":"131I Therapy for elevated thyroglobulin levels","volume":"7","year":"1997","journal-title":"Thyroid"},{"key":"ref341","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1007\/s12022-011-9164-9","article-title":"Well-differentiated thyroid carcinoma with concomitant Hashimoto\u2019s thyroiditis present with less aggressive clinical stage and low recurrence","volume":"22","year":"2011","journal-title":"Endocrine Pathology"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.clon.2012.01.001","article-title":"Iodine or Not (IoN) for low-risk differentiated thyroid cancer: the next UK national cancer research network randomized trial following HiLo","volume":"24","year":"2012","journal-title":"Clinical Oncology"}],"container-title":["Endocrine 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