{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T22:10:46Z","timestamp":1790892646613,"version":"4.1.0"},"reference-count":68,"publisher":"Bioscientifica","issue":"4","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ec.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The effect of isolated maternal hypothyroxinaemia (IMH) on pregnancy complications and neonatal outcomes in human beings is still controversial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a retrospective cohort study based on the electronic medical register system. The records of women with a singleton pregnancy who sought antenatal examination between January 2014 and December 2015 at Shanghai First Maternity and Infant Hospital were extracted from the electronic medical records system. Thyroid-stimulating hormone (TSH), free thyroxine (fT4) and anti-thyroperoxidase autoantibody (TPO-Ab) was measured before 20 gestational weeks, and a multiple logistic regression model was used to estimate the odds ratios of pregnancy complications and neonatal outcomes between euthyroid women and those with isolated hypothyroxinaemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 8173 women were included in this study, of whom 342 (4.18%) were diagnosed with IMH. Regression analysis showed that IMH diagnosed in the second trimester (13\u201320 weeks) was associated with an increased risk of hypertensive disorders of pregnancy (OR\u2009=\u20092.66, 95% CI: 1.38\u20135.10) and placenta abruption (OR\u2009=\u20093.64, 95% CI: 1.07\u201312.41), but not with preterm delivery (OR\u2009=\u20091.09, 95% CI: 0.50\u20132.40), small or large gestational age of infant (OR\u2009=\u20090.91, 95% CI: 0.39\u20132.12; OR\u2009=\u20091.16, 95% CI: 0.72\u20131.86), macrosomia (OR\u2009=\u20091.71, 95% CI: 0.95\u20133.07), gestational diabetes mellitus (OR\u2009=\u20091.36, 95% CI: 0.86\u20132.15) and placenta previa (OR\u2009=\u20091.62, 95% CI: 0.39\u20137.37).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>IMH could be a risk factor for hypertensive disorders of pregnancy.<\/jats:p>\n                  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