{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:17:05Z","timestamp":1784557025181,"version":"3.55.0"},"reference-count":96,"publisher":"Bioscientifica","issue":"4","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ec.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Walking and postural balance are extremely important to obtain food and to work. Both are critical for quality of life and ability to survive. While walking reflects musculoskeletal and cardiopulmonary systems, postural balance depends on body size, muscle tone, visual, vestibular and nervous systems. Since GH and IGF-I act on all these systems, we decided to study those parameters in a cohort of individuals with severe short stature due to untreated isolated GH deficiency (IGHD) caused by a mutation in the GHRH receptor gene. These IGHD subjects, despite reduction in muscle mass, are very active and have normal longevity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a cross-sectional study, we assessed walking (by a 6-min walk test), postural balance (by force platform) and fall risk (by the 'Timed Up and Go' test) in 31 IGHD and 40 matched health controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The percentage of the walked distance measured in relation to the predicted one was similar in groups, but higher in IGHD, when corrected by the leg length. Absolute postural balance data showed similar velocity of unipodal support in the two groups, and better values, with open and closed eyes and unipodal support, in IGHD, but these differences became non-significant when corrected for height and lower-limb length. The time in 'Timed Up and Go' test was higher in IGHD cohort, but still below the cut-off value for fall risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>IGHD subjects exhibit satisfactory walking and postural balance, without increase in fall risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/ec-19-0103","type":"journal-article","created":{"date-parts":[[2019,3,13]],"date-time":"2019-03-13T15:46:32Z","timestamp":1552491992000},"page":"416-424","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-10","source":"Crossref","is-referenced-by-count":5,"title":["Walking and postural balance in adults with severe short stature due to isolated GH deficiency"],"prefix":"10.1530","volume":"8","author":[{"given":"Ananda A","family":"Santana-Ribeiro","sequence":"first","affiliation":[{"name":"1Laboratory of Motor Control and Body Balance, Center for Health Science Research, Federal University of Sergipe, Sergipe, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulliani A","family":"Moreira-Brasileiro","sequence":"additional","affiliation":[{"name":"1Laboratory of Motor Control and Body Balance, Center for Health Science Research, Federal University of Sergipe, Sergipe, Brazil"},{"name":"2Department of Physical Therapy and Post-Graduate Program in Health Science, Federal University of Sergipe, The GREAT Group (GRupo de Estudos em ATividade f\u00edsica), Sergipe, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel H","family":"Aguiar-Oliveira","sequence":"additional","affiliation":[{"name":"3Division of Endocrinology, Federal University of Sergipe, Aracaju, Sergipe, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Salvatori","sequence":"additional","affiliation":[{"name":"4Division of Endocrinology, Diabetes and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitor O","family":"Carvalho","sequence":"additional","affiliation":[{"name":"2Department of Physical Therapy and Post-Graduate Program in Health Science, Federal University of Sergipe, The GREAT Group (GRupo de Estudos em ATividade f\u00edsica), Sergipe, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia K","family":"Alvim-Pereira","sequence":"additional","affiliation":[{"name":"1Laboratory of Motor Control and Body Balance, Center for Health Science Research, Federal University of Sergipe, Sergipe, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos R","family":"Ara\u00fajo-Daniel","sequence":"additional","affiliation":[{"name":"5Department of Statistic and Actuarial Sciences, Federal University of Sergipe, Aracaju, Sergipe, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00falia G","family":"Reis-Costa","sequence":"additional","affiliation":[{"name":"1Laboratory of Motor Control and Body Balance, Center for Health Science Research, Federal University of Sergipe, Sergipe, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alana L","family":"Andrade-Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"1Laboratory of Motor Control and Body Balance, Center for Health Science Research, Federal University of Sergipe, Sergipe, Brazil"},{"name":"2Department of Physical Therapy and Post-Graduate Program in Health Science, Federal University of Sergipe, The GREAT Group (GRupo de Estudos em ATividade f\u00edsica), Sergipe, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Al\u00e9cia A","family":"Oliveira-Santos","sequence":"additional","affiliation":[{"name":"3Division of Endocrinology, Federal University of Sergipe, Aracaju, Sergipe, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar R","family":"Vieira","sequence":"additional","affiliation":[{"name":"6Department of Physical Therapy and Neuroscience, Wertheims\u2019 College of Nursing and Health Science, Florida International University, Miami, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miburge B","family":"Gois-Junior","sequence":"additional","affiliation":[{"name":"1Laboratory of Motor Control and Body Balance, Center for Health Science Research, Federal University of Sergipe, Sergipe, Brazil"},{"name":"2Department of Physical Therapy and Post-Graduate Program in Health Science, Federal University of Sergipe, The GREAT Group (GRupo de Estudos em ATividade f\u00edsica), Sergipe, Brazil"},{"name":"6Department of Physical Therapy and Neuroscience, Wertheims\u2019 College of Nursing and Health Science, Florida International University, Miami, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"ref121","first-page":"85","article-title":"NetoLASalvatoriR MECHANISMS IN The multiple facets of GHRH axis lessons from lifetime untreated isolated GH deficiency due to a GHRH receptor gene mutation of https org","author":"Aguiar","journal-title":"ENDOCRINOLOGY European Journal Endocrinology"},{"key":"ref81","first-page":"1","article-title":"Dynamical properties of postural control in obese community-dwelling older adults","volume":"18","year":"2018","journal-title":"Sensors"},{"key":"ref331","doi-asserted-by":"crossref","first-page":"3285","DOI":"10.1210\/jc.2014-2132","article-title":"Increased visceral adiposity and cortisol to cortisone ratio in adults with congenital lifetime isolated GH deficiency","volume":"99","year":"2014","journal-title":"Journal of Clinical Endocrinology and 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deficiency have satisfactory muscular function","volume":"63","year":"2019","journal-title":"Endocrine"},{"key":"ref401","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1177\/1071100714531227","article-title":"Limits of stability and adaptation to wearing rocker bottom shoes","volume":"35","year":"2014","journal-title":"Foot and Ankle International"},{"key":"ref591","first-page":"[epub]","article-title":"Relationship between body mass index and static and dynamic balance in active and inactive older adults","year":"2018","journal-title":"Journal of Geriatric Physical Therapy"},{"key":"ref671","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1007\/s12020-018-1763-5","article-title":"Adult individuals with congenital, untreated, severe isolated growth hormone deficiency have satisfactory muscular function","volume":"63","year":"2019","journal-title":"Endocrine"},{"key":"ref851","first-page":"191","article-title":"Lifetime, untreated isolated GH deficiency due to a 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Comparison with cardiopulmonary exercise testing","volume":"161","year":"2000","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"ref701","first-page":"[epub]","article-title":"Reliability and validity of computerized force platform measures of balance function in healthy older adults","year":"2018","journal-title":"Journal of Geriatric Physical Therapy"},{"key":"ref931","first-page":"745","article-title":"Effect of somatosensory and neurofeedback training on balance in older healthy adults: a preliminary investigation","volume":"30","year":"2017","journal-title":"Aging: Clinical and Experimental Research"},{"key":"ref691","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1519\/JPT.0000000000000111","article-title":"Validity and reliability of a portable balance tracking system, btracks, in older adults","volume":"41","year":"2018","journal-title":"Journal of Geriatric Physical 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