{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:55:03Z","timestamp":1792727703924,"version":"4.5.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"7","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ec.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,7]]},"abstract":"\n Background<\/jats:title>\n \n The management of adrenal incidentaloma is still a challenge with respect to determining its functionality (hormone secretion) and malignancy. In this light, we performed\n 18<\/jats:sup>\n F-FDG PET\/CT scan to assess the SUV\n max<\/jats:sub>\n values in different adrenal masses including Cushing syndrome, pheochromocytoma, primary hyperaldosteronism and non-functional adrenal adenomas.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Total 109 (73 F, 36 M) patients with adrenal mass (incidentaloma), mean age of 53.3\u2009\u00b1\u200910.2 years (range, 24\u201370) were screened by\n 18<\/jats:sup>\n F-FDG PET\/CT. Data of\n 18<\/jats:sup>\n F-FDG PET\/CT imaging of the patients were assessed by the same specialist. Adrenal masses were identified according to the calculated standardized uptake values (SUVs). Clinical examination, 24-h urine cortisol, catecholamine metabolites, 1-mg dexamethasone suppression test, aldosterone\/renin ratio and serum electrolytes were analyzed.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Based on the clinical and hormonal evaluations, there were 100 patients with non-functional adrenal mass, four with cortisol-secreting, four with pheochromocytomas and one with aldosterone-secreting adenoma. Mean adrenal mass diameter of 109 patients was 2.1\u2009\u00b1\u20094.3 (range, 1\u20136.5\u2009cm). The\n 18<\/jats:sup>\n F-FDG PET\/CT imaging of the patients revealed that lower SUV\n max<\/jats:sub>\n values were found in non-functional adrenal masses (SUV\n max<\/jats:sub>\n 3.2) when compared to the functional adrenal masses including four with cortisol-secreting adenoma (SUV\n max<\/jats:sub>\n 10.1); four with pheochromcytoma (SUV\n max<\/jats:sub>\n 8.7) and one with aldosterone-secreting adenomas (SUV\n max<\/jats:sub>\n 3.30). Cortisol-secreting (Cushing syndrome) adrenal masses showed the highest SUV\n max<\/jats:sub>\n value (10.1), and a cut-off SUV\n max<\/jats:sub>\n of 4.135 was found with an 84.6% sensitivity and 75.6% specificity cortisol-secreting adrenal adenoma.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Consistent with the similar studies, non-functional adrenal adenomas typically do not show increased FDG uptake and a certain form of functional adenoma could present various FDG uptake in FDG PET\/CT. Especially functional adrenal adenomas (cortisol secreting was the highest) showed increased FDG uptake in comparison to the non-functional adrenal masses. Therefore, setting a specific SUV\n max<\/jats:sub>\n value in the differentiation of malignant adrenal lesion from the benign one is risky and further studies, including a high number of functional adrenal mass are needed.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1530\/ec-19-0204","type":"journal-article","created":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T13:07:42Z","timestamp":1559048862000},"page":"838-845","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-10","source":"Crossref","is-referenced-by-count":38,"title":["Diagnostic efficacy of 18F-FDG PET\/CT in patients with adrenal incidentaloma"],"prefix":"10.1530","volume":"8","author":[{"given":"Gamze","family":"Akku\u015f","sequence":"first","affiliation":[{"name":"1Division of Endocrinology, Internal Medicine and Endocrinology, Cukurova University Medical Faculty, Department of Internal Medicine, Adana, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isa Burak","family":"G\u00fcney","sequence":"additional","affiliation":[{"name":"2Nuclear Medicine Department, Cukurova University Medical Faculty, Adana, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fesih","family":"Ok","sequence":"additional","affiliation":[{"name":"3Urology Department, Cukurova University Medical Faculty, Adana, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehtap","family":"Evran","sequence":"additional","affiliation":[{"name":"1Division of Endocrinology, Internal Medicine and Endocrinology, Cukurova University Medical Faculty, Department of Internal Medicine, Adana, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volkan","family":"Izol","sequence":"additional","affiliation":[{"name":"3Urology Department, Cukurova University Medical Faculty, Adana, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u015eeyda","family":"Erdo\u011fan","sequence":"additional","affiliation":[{"name":"4Pathology Department, Cukurova University Medical Faculty, Adana, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y\u0131ld\u0131r\u0131m","family":"Bayaz\u0131t","sequence":"additional","affiliation":[{"name":"3Urology Department, Cukurova University Medical Faculty, Adana, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Sert","sequence":"additional","affiliation":[{"name":"1Division of Endocrinology, Internal Medicine and Endocrinology, Cukurova University Medical Faculty, Department of Internal Medicine, Adana, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamer","family":"Tetiker","sequence":"additional","affiliation":[{"name":"1Division of Endocrinology, Internal Medicine and Endocrinology, Cukurova University Medical Faculty, Department of Internal Medicine, Adana, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Endocrine Connections"],"original-title":[],"link":[{"URL":"https:\/\/ec.bioscientifica.com\/view\/journals\/ec\/8\/7\/EC-19-0204.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ec.bioscientifica.com\/downloadpdf\/journals\/ec\/8\/7\/EC-19-0204.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:43:32Z","timestamp":1784555012000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/ec\/article\/8\/7\/838-845\/540"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":0,"journal-issue":{"issue":"7"},"URL":"https:\/\/doi.org\/10.1530\/ec-19-0204","relation":{},"ISSN":["2049-3614"],"issn-type":[{"value":"2049-3614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7]]}}}