{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:16:16Z","timestamp":1784556976243,"version":"3.55.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"7","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ec.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,7]]},"abstract":"\n Objective<\/jats:title>\n \n To investigate the mutant status of\n BRAF<\/jats:italic>\n gene and analyze its relationship to epidemiological risk factors and clinical outcomes among patients with papillary thyroid cancer (PTC) in the largest, single-institution Chinese cohort to date.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n The medical records of 2048 PTC patients were reviewed in this retrospective study. Single-factor and multiple logistic regression analyses were applied to identify risk factors for\n BRAF<\/jats:italic>\n V600E mutation. Survival outcomes including distant metastatic and persistent or recurrent PTC were examined, with a mean follow-up time of 23.4 (5\u201347) months.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The\n BRAF<\/jats:italic>\n V600E mutation was present in 83.7% of patients (1715 of 2048). Correlation was found between\n BRAF<\/jats:italic>\n V600E mutation and several epidemiological features, including age, concomitant hypertension and Hashimoto thyroiditis (HT). For the clinicopathological features,\n BRAF<\/jats:italic>\n V600E was significantly associated with bilateral multifocality (odds ratio (OR) 1.233, 95% confidence interval (CI) 1.063\u20131.431,\n P<\/jats:italic>\n \u2009<\u20090.01) and less lateral lymph node metastases (OR 0.496, 95% CI 0.357\u20130.689,\n P<\/jats:italic>\n \u2009<\u20090.01). Smaller tumor size and advanced disease stage were significant in single-factor analyses but became insignificant after multivariate adjustment. No association was found between\n BRAF<\/jats:italic>\n V600E mutation and extrathyroidal invasion, distant metastatic and disease persistence or recurrence.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Part of epidemiological features are independent risk or protective factors for\n BRAF<\/jats:italic>\n V600E mutation. The presence of\n BRAF<\/jats:italic>\n V600E mutation is not an aggressive prognosis on poor clinical outcomes in PTC. However, the high prevalence of\n BRAF<\/jats:italic>\n V600E may provide guidance for surgery strategy and opportunity for targeted treatment in recurrent and advanced stage disease.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1530\/ec-19-0246","type":"journal-article","created":{"date-parts":[[2019,6,28]],"date-time":"2019-06-28T11:34:51Z","timestamp":1561721691000},"page":"988-996","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-10","source":"Crossref","is-referenced-by-count":75,"title":["Relationship between BRAF V600E and clinical features in papillary thyroid carcinoma"],"prefix":"10.1530","volume":"8","author":[{"given":"Changjiao","family":"Yan","sequence":"first","affiliation":[{"name":"1Department of Thyroid, Breast and Vascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi\u2019an, Shaanxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiling","family":"Huang","sequence":"additional","affiliation":[{"name":"1Department of Thyroid, Breast and Vascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi\u2019an, Shaanxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[{"name":"1Department of Thyroid, Breast and Vascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi\u2019an, Shaanxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Wang","sequence":"additional","affiliation":[{"name":"1Department of Thyroid, Breast and Vascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi\u2019an, Shaanxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Ling","sequence":"additional","affiliation":[{"name":"1Department of Thyroid, Breast and Vascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi\u2019an, Shaanxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Endocrine Connections"],"original-title":[],"link":[{"URL":"https:\/\/ec.bioscientifica.com\/view\/journals\/ec\/8\/7\/EC-19-0246.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ec.bioscientifica.com\/downloadpdf\/journals\/ec\/8\/7\/EC-19-0246.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:43:34Z","timestamp":1784555014000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/ec\/article\/8\/7\/988-996\/536"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":0,"journal-issue":{"issue":"7"},"URL":"https:\/\/doi.org\/10.1530\/ec-19-0246","relation":{},"ISSN":["2049-3614"],"issn-type":[{"value":"2049-3614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7]]}}}