{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:15:54Z","timestamp":1789085754317,"version":"build-2803163510"},"reference-count":0,"publisher":"Bioscientifica","issue":"9","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ec.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,9]]},"abstract":"\n Background<\/jats:title>\n Non-adherence to r-hGH treatments occurs in a variable percentage of subjects. One problem found when evaluating adherence is the great variability in methods of detection and definitions utilized in studies. This study assessed the level of adherence in subjects receiving r-hGH with the easypod\u2122 electronic device.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n National, multicenter, prospective and observational study involving 238 subjects (144 with GH deficiency (GHD), and 86 with small for gestational age (SGA), 8 with Turner Syndrome), who received r-hGH with easypod\u2122 for at least 3 months before inclusion. The follow-up period was 4 years.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Overall adherence was 94.5%; 97.5% after 6 months, 95.3% after 1 year, 93.7% after 2, 94.4% after 3 and 95.5% after 4 years of treatment. No differences in adherence were observed between prepubertal and pubertal groups and GHD and SGA groups. Change in height after 1 and 2 years, change in height SDS after 1 and 2 years, HV after 1 year, HV SDS after at 1 and 4 years, change in BMI after 1 year and change in BMI SDS at 1 and 2 years showed significant correlation with adherence. No significant differences in adherence according to IGF-I levels were found in follow-up visits or between groups.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The easypod\u2122 electronic device, apart from being a precise and objective measure of adherence to r-hGH treatment, allows high compliance rates to be achieved over long periods of time. Adherence significantly impacts growth outcomes associated with r-hGH treatment.<\/jats:p>\n <\/jats:sec>","DOI":"10.1530\/ec-19-0325","type":"journal-article","created":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T06:34:52Z","timestamp":1567578892000},"page":"1240-1249","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-10","source":"Crossref","is-referenced-by-count":33,"title":["Adherence and long-term outcomes of growth hormone therapy with easypod\u2122 in pediatric subjects: Spanish ECOS study"],"prefix":"10.1530","volume":"8","author":[{"given":"Mar\u00eda Dolores","family":"Rodr\u00edguez Arnao","sequence":"first","affiliation":[{"name":"1Pediatric Endocrinology Unit, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amparo","family":"Rodr\u00edguez S\u00e1nchez","sequence":"additional","affiliation":[{"name":"1Pediatric Endocrinology Unit, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"D\u00edez L\u00f3pez","sequence":"additional","affiliation":[{"name":"2Hospital Universitario Araba, Araba\/Alava, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaqu\u00edn","family":"Ram\u00edrez Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"3Hospital Universitario Pr\u00edncipe de Asturias, Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Antonio","family":"Berm\u00fadez de la Vega","sequence":"additional","affiliation":[{"name":"4Centro Nuevas Tecnologias, Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Yeste Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"5Hospital Vall d\u2019Hebr\u00f3n, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Chueca Guindulain","sequence":"additional","affiliation":[{"name":"6Complejo Hospitalario de Navarra, Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Corripio Collado","sequence":"additional","affiliation":[{"name":"7Corporaci\u00f3 Sanit\u00e0ria Parc Taul\u00ed, Sabadell, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacobo","family":"P\u00e9rez S\u00e1nchez","sequence":"additional","affiliation":[{"name":"7Corporaci\u00f3 Sanit\u00e0ria Parc Taul\u00ed, Sabadell, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Fern\u00e1ndez Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"8Merck S.L.U., Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"_","family":"_","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Endocrine Connections"],"original-title":[],"link":[{"URL":"https:\/\/ec.bioscientifica.com\/view\/journals\/ec\/8\/9\/EC-19-0325.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ec.bioscientifica.com\/downloadpdf\/journals\/ec\/8\/9\/EC-19-0325.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:43:41Z","timestamp":1784555021000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/ec\/article\/8\/9\/1240-1249\/574"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":0,"journal-issue":{"issue":"9"},"URL":"https:\/\/doi.org\/10.1530\/ec-19-0325","relation":{},"ISSN":["2049-3614"],"issn-type":[{"value":"2049-3614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9]]}}}