{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:23:52Z","timestamp":1792167832006,"version":"4.4.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"10","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ec.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,10]]},"abstract":"\n Aim<\/jats:title>\n To investigate risk of thyroid disease in Danish women with PCOS.<\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n \n National register-based study on women with PCOS in Denmark. 18,476 women had a diagnosis of PCOS in the Danish National Patient Register. PCOS Odense University Hospital (PCOS OUH,\n n<\/jats:italic>\n \u2009=\u20091146) was an embedded cohort of women with PCOS and clinical and biochemical examination. Three age-matched controls were included for each woman with PCOS (\n n<\/jats:italic>\n \u2009=\u200954,757). The main outcome measures were thyroid disease (hypothyroidism, Graves\u2019 disease, goiter, thyroiditis) according to hospital diagnosis codes and\/or inferred from filled medicine prescriptions. Associations between baseline TSH and development of cardio-metabolic disease was examined in PCOS OUH.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The median (quartiles) age at inclusion was 29 (23\u201335) years and follow-up duration was 11.1 (6.9\u201316.0) years. The hazard ratio (95% CI) for thyroid disease development was 2.5 (2.3\u20132.7) (\n P<\/jats:italic>\n \u2009<\u20090.001). The event rate of thyroid disease was 6.0 per 1000 patient-years in PCOS Denmark versus 2.4 per 1000 patient-years in controls (\n P<\/jats:italic>\n \u2009<\u20090.001). Women in PCOS OUH with TSH \u22652.5\u2009mIU\/L (\n n<\/jats:italic>\n \u2009=\u2009133) had higher BMI (median 29 vs 27\u2009kg\/m\n 2<\/jats:sup>\n ), wider waist, higher triglycerides and free testosterone by the time of PCOS diagnosis compared to women in PCOS OUH with TSH <2.5\u2009mIU\/L (\n n<\/jats:italic>\n \u2009=\u2009588). Baseline TSH did not predict later development of cardio-metabolic diseases in PCOS OUH.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The event rate of thyroid disease was significantly and substantially higher in women with PCOS compared to controls.<\/jats:p>\n <\/jats:sec>","DOI":"10.1530\/ec-19-0377","type":"journal-article","created":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T09:37:36Z","timestamp":1568367456000},"page":"1405-1415","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-10","source":"Crossref","is-referenced-by-count":30,"title":["Increased risk of thyroid disease in Danish women with polycystic ovary syndrome: a cohort study"],"prefix":"10.1530","volume":"8","author":[{"given":"Dorte","family":"Glintborg","sequence":"first","affiliation":[{"name":"1Department of Endocrinology, Odense University Hospital, Odense, Denmark"},{"name":"2Institute of Clinical Research, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrine Hass","family":"Rubin","sequence":"additional","affiliation":[{"name":"3OPEN \u2013 Odense Patient data Explorative Network, Department of Clinical Research, University of Southern Denmark and Odense University Hospital, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mads","family":"Nybo","sequence":"additional","affiliation":[{"name":"4Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Abrahamsen","sequence":"additional","affiliation":[{"name":"3OPEN \u2013 Odense Patient data Explorative Network, Department of Clinical Research, University of Southern Denmark and Odense University Hospital, Odense, Denmark"},{"name":"5Department of Medicine, Holb\u00e6k Hospital, Holb\u00e6k, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Andersen","sequence":"additional","affiliation":[{"name":"1Department of Endocrinology, Odense University Hospital, Odense, Denmark"},{"name":"2Institute of Clinical Research, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Endocrine Connections"],"original-title":[],"link":[{"URL":"https:\/\/ec.bioscientifica.com\/view\/journals\/ec\/8\/10\/EC-19-0377.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ec.bioscientifica.com\/downloadpdf\/journals\/ec\/8\/10\/EC-19-0377.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:43:43Z","timestamp":1784555023000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/ec\/article\/8\/10\/1405-1415\/584"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":0,"journal-issue":{"issue":"10"},"URL":"https:\/\/doi.org\/10.1530\/ec-19-0377","relation":{},"ISSN":["2049-3614"],"issn-type":[{"value":"2049-3614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10]]}}}