{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:17:18Z","timestamp":1784557038198,"version":"3.55.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"4","content-domain":{"domain":["ec.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,4]]},"abstract":"\n Purpose<\/jats:title>\n Observational studies show that longer breastfeeding periods reduce maternal risk of type 2 diabetes mellitus. However, it is currently unknown if the long-term benefits of breastfeeding for maternal glucose homeostasis are linked to changes in the endocrine pancreas.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We presently evaluated functional, morphological and molecular aspects of the endocrine pancreas of mice subjected to two sequential cycles of pregnancy and lactation (L21). Age-matched mice not allowed to breastfeed (L0) and virgin mice were used as controls.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n L21 mice exhibited increased tolerance and increased glucose-stimulated insulin secretion (GSIS) by isolated islets. Pancreatic islets of L21 mice did not present evident morphological changes to justify the increased GSIS. On the other hand, islets of L21 mice exhibited a reduction in\n Cavb3<\/jats:italic>\n and\n Kir6.2<\/jats:italic>\n expression with concordant increased intracellular Ca\n 2+<\/jats:sup>\n levels after challenge with glucose.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Altogether, the present findings show the breastfeeding exerts long-term benefits for maternal endocrine pancreas by increasing intracellular Ca\n 2+<\/jats:sup>\n levels and GSIS.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1530\/ec-20-0020","type":"journal-article","created":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T11:07:26Z","timestamp":1584443246000},"page":"299-308","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-10","source":"Crossref","is-referenced-by-count":9,"title":["Long-term increase of insulin secretion in mice subjected to pregnancy and lactation"],"prefix":"10.1530","volume":"9","author":[{"given":"Julia Modesto","family":"Vicente","sequence":"first","affiliation":[{"name":"1Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junia Carolina","family":"Santos-Silva","sequence":"additional","affiliation":[{"name":"1Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caio Jord\u00e3o","family":"Teixeira","sequence":"additional","affiliation":[{"name":"1Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dailson Nogueira","family":"de Souza","sequence":"additional","affiliation":[{"name":"1Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Franciesco","family":"Vettorazzi","sequence":"additional","affiliation":[{"name":"2Department of Structural and Functional Biology, Institute of Biology, State University of Campinas, Campinas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiola Sales","family":"Furtuoso","sequence":"additional","affiliation":[{"name":"1Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel Gouveia","family":"Adabo","sequence":"additional","affiliation":[{"name":"1Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio Takeo","family":"Sato","sequence":"additional","affiliation":[{"name":"3Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, State University of Campinas, Campinas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco Aur\u00e9lio Ramirez","family":"Vinolo","sequence":"additional","affiliation":[{"name":"3Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, State University of Campinas, Campinas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Everardo Magalh\u00e3es","family":"Carneiro","sequence":"additional","affiliation":[{"name":"2Department of Structural and Functional Biology, Institute of Biology, State University of Campinas, Campinas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana","family":"Bordin","sequence":"additional","affiliation":[{"name":"4Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel Forato","family":"Anh\u00ea","sequence":"additional","affiliation":[{"name":"1Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Endocrine Connections"],"original-title":[],"link":[{"URL":"https:\/\/ec.bioscientifica.com\/view\/journals\/ec\/9\/4\/EC-20-0020.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ec.bioscientifica.com\/downloadpdf\/journals\/ec\/9\/4\/EC-20-0020.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:43:54Z","timestamp":1784555034000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/ec\/article\/9\/4\/299-308\/660"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":0,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.1530\/ec-20-0020","relation":{},"ISSN":["2049-3614"],"issn-type":[{"value":"2049-3614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4]]}}}