{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:19:37Z","timestamp":1790720377466,"version":"4.1.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"4","content-domain":{"domain":["ec.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,4]]},"abstract":"\n Introduction and aim<\/jats:title>\n \n Ectopic ACTH secretion (EAS) is mostly secondary to thoracic\/abdominal neuroendocrine tumours (NETs) or small cell-lung carcinoma (SCLC). We studied the diagnostic accuracy of CT with\n 68<\/jats:sup>\n Ga-Dota derivatives (\n 68<\/jats:sup>\n Ga-SSTR) PET in localizing ACTH-secreting tumor in patients with EAS.\n <\/jats:p>\n <\/jats:sec>\n \n Materials and methods<\/jats:title>\n \n 68<\/jats:sup>\n Ga-SSTR-PET\/CT was performed and compared with the nearest enhanced CT in 18 cases (16 primary and 2 recurrent neoplasms). Unspecific, indeterminate and false-positive uptakes were assessed using conventional imaging, follow-up or histology.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n We diagnosed 13 thoracic (9 primary and 2 recurrent bronchial carcinoids, 2 SCLCs) and 1 abdominal (pancreatic NET) tumors. Eight ACTH-secreting tumors were promptly identified at EAS diagnosis (\u2019overt\u2019, four pulmonary carcinoids with two recurrences and two SCLC); six EAS have been discovered during the subsequent follow-up (\u2019covert\u2019, five bronchial carcinoids and one pancreatic NET). At the time of EAS diagnosis, imaging was able to correctly detect the ACTH-secreting tumour in 8\/18 cases (6 new diagnosis and 2 recurrences). During the follow-up, six out of initially ten \u2018occult\u2019 cases became \u2018covert\u2019. At last available follow-up, CT and\n 68<\/jats:sup>\n Ga-SSTR-PET\/CT were able to diagnose 11\/18 and 12\/18 ACTH-secreting tumours, respectively (11\/14 and 12\/14 considering only overt and covert cases, respectively). Four cases have never been localized by conventional or nuclear imaging (\u2019occult EAS\u2019), despite an average follow-up of 5 years.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n The\n 68<\/jats:sup>\n Ga-SSTR-PET\/CT is useful in localizing EAS, especially to enhance positive prediction of the suggestive CT lesions and to detect occult neoplasms.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1530\/ec-20-0089","type":"journal-article","created":{"date-parts":[[2020,3,26]],"date-time":"2020-03-26T10:34:48Z","timestamp":1585218888000},"page":"337-345","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-10","source":"Crossref","is-referenced-by-count":18,"title":["The role of 68Ga-DOTA derivatives PET-CT in patients with ectopic ACTH syndrome"],"prefix":"10.1530","volume":"9","author":[{"given":"Filippo","family":"Ceccato","sequence":"first","affiliation":[{"name":"1Endocrinology Unit, Department of Medicine DIMED, University-Hospital of Padova, Padova, Italy"},{"name":"2Department of Neuroscience DNS, University of Padova, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Cecchin","sequence":"additional","affiliation":[{"name":"2Department of Neuroscience DNS, University of Padova, Padova, Italy"},{"name":"3Nuclear Medicine Unit, Department of Medicine \u2013 DIMED, University-Hospital of Padova, Padova, Italy"},{"name":"4Padova Neuroscience Center PNC, University of Padova, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Gregianin","sequence":"additional","affiliation":[{"name":"5Nuclear Medicine Unit, Castelfranco Veneto, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Ricci","sequence":"additional","affiliation":[{"name":"2Department of Neuroscience DNS, University of Padova, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Campi","sequence":"additional","affiliation":[{"name":"4Padova Neuroscience Center PNC, University of Padova, Padova, Italy"},{"name":"6Department of Mathematics \u2018Tullio Levi-Civita\u2019 DM, University of Padova, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Crim\u00ec","sequence":"additional","affiliation":[{"name":"7Radiology Unit, Department of Medicine DIMED, University-Hospital of Padova, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Bergamo","sequence":"additional","affiliation":[{"name":"1Endocrinology Unit, Department of Medicine DIMED, University-Hospital of Padova, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annibale","family":"Versari","sequence":"additional","affiliation":[{"name":"8Nuclear Medicine Unit, Reggio Emilia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmelo","family":"Lacognata","sequence":"additional","affiliation":[{"name":"9Radiology Department, University-Hospital of Padova, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Rea","sequence":"additional","affiliation":[{"name":"10Thoracic Surgery Unit, Department of Cardiac, Thoracic and Vascular Sciences, University Hospital of Padova, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattia","family":"Barbot","sequence":"additional","affiliation":[{"name":"1Endocrinology Unit, Department of Medicine DIMED, University-Hospital of Padova, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Scaroni","sequence":"additional","affiliation":[{"name":"1Endocrinology Unit, Department of Medicine DIMED, University-Hospital of Padova, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Endocrine Connections"],"original-title":[],"link":[{"URL":"https:\/\/ec.bioscientifica.com\/view\/journals\/ec\/9\/4\/EC-20-0089.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ec.bioscientifica.com\/downloadpdf\/journals\/ec\/9\/4\/EC-20-0089.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:43:57Z","timestamp":1784555037000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/ec\/article\/9\/4\/337-345\/661"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":0,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.1530\/ec-20-0089","relation":{},"ISSN":["2049-3614"],"issn-type":[{"value":"2049-3614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4]]}}}