{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:17:13Z","timestamp":1784557033483,"version":"3.55.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"8","content-domain":{"domain":["ec.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:sec>\n                    <jats:title>\n                      <jats:italic>Objective:<\/jats:italic>\n                    <\/jats:title>\n                    <jats:p>The dental and periodontal impact of GH\/IGF-1 hypersecretion has been poorly investigated until now. Our aim is to precisely describe the oro-dental state of acromegalic patients and to study the impact of GH\/IGF-1 hypersecretion on patients\u2019 reported oral health-related quality of life (OHRQoL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\n                      <jats:italic>Methods:<\/jats:italic>\n                    <\/jats:title>\n                    <jats:p>After collecting characteristics of their disease, acromegalic patients answered the GOHAI questionnaire assessing their OHRQoL, the AcroQoL questionnaire and then benefited from a complete stomatological and radiological examination (orthopantomogram systematically, retro-alveolar radiography or Cone Beam CT if necessary).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\n                      <jats:italic>Results:<\/jats:italic>\n                    <\/jats:title>\n                    <jats:p>In total, 29 patients aged 59.1 \u00b1 16.0 years were included. The average DMFT index (sum of Decayed, Missing and Filled Teeth per patient) was 19.0 \u00b1 7.8. 16\/29 patients had a gingivitis and 18\/29 a mild to moderate chronic periodontitis, but no case of severe chronic periodontitis was found, probably because the frequency of a protective thick gingival biotype was increased (9\/29). No case of generalized gingival hypertrophy or diffuse hypercementosis was observed. According to the Add-GOHAI score, only 8\/26 patients had a satisfactory OHRQoL. This parameter was correlated to the acromegaly-specific quality of life according to the AcroQoL score. Interestingly, 11\/29 patients had bulky oral bony outgrowths (OBO), such as large maxillary or mandibular tori and multiple vestibular exostosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\n                      <jats:italic>Conclusions:<\/jats:italic>\n                    <\/jats:title>\n                    <jats:p>The unsatisfactory OHRQoL reported by acromegalic patients contrasts with a rather good objective oro-dental state and annual oral examination seems relevant in this population. Finally, we report that huge OBO could be helpful signposts for the diagnosis of acromegaly.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/ec-20-0176","type":"journal-article","created":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T07:07:28Z","timestamp":1596611248000},"page":"824-833","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-10","source":"Crossref","is-referenced-by-count":9,"title":["Assessment of oro-dental manifestations in a series of acromegalic patients, the AcroDent study"],"prefix":"10.1530","volume":"9","author":[{"given":"Sylvain","family":"Roumeau","sequence":"first","affiliation":[{"name":"1CHU de Clermont-Ferrand, Service d\u2019Endocrinologie, Diab\u00e9tologie et Maladies M\u00e9taboliques, Clermont-Ferrand, France"},{"name":"2Universit\u00e9 Clermont Auvergne, Facult\u00e9 de M\u00e9decine, Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joannice","family":"Thevenon","sequence":"additional","affiliation":[{"name":"3CHU Clermont-Ferrand, Service d\u2019Odontologie, Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lemlih","family":"Ouchchane","sequence":"additional","affiliation":[{"name":"4Universit\u00e9 Clermont Auvergne, CNRS, ISIT, Clermont-Ferrand, France"},{"name":"5CHU Clermont-Ferrand, Service de Biostatistiques, Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salwan","family":"Maqdasy","sequence":"additional","affiliation":[{"name":"2Universit\u00e9 Clermont Auvergne, Facult\u00e9 de M\u00e9decine, Clermont-Ferrand, France"},{"name":"6CHU de Clermont-Ferrand, Service d\u2019Endocrinologie, Diab\u00e9tologie et Maladies M\u00e9taboliques, Clermont-Ferrand, France"},{"name":"7Laboratoire GReD: UMR Universit\u00e9 Clermont Auvergne-CNRS 6293, INSERM U1103, Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Batisse-Lignier","sequence":"additional","affiliation":[{"name":"6CHU de Clermont-Ferrand, Service d\u2019Endocrinologie, Diab\u00e9tologie et Maladies M\u00e9taboliques, Clermont-Ferrand, France"},{"name":"7Laboratoire GReD: UMR Universit\u00e9 Clermont Auvergne-CNRS 6293, INSERM U1103, Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Duale","sequence":"additional","affiliation":[{"name":"8Universit\u00e9 Clermont Auvergne, Inserm, Neuro-Dol, Clermont-Ferrand, France"},{"name":"9CHU Clermont-Ferrand, Inserm CIC 1405, Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Pham Dang","sequence":"additional","affiliation":[{"name":"2Universit\u00e9 Clermont Auvergne, Facult\u00e9 de M\u00e9decine, Clermont-Ferrand, France"},{"name":"8Universit\u00e9 Clermont Auvergne, Inserm, Neuro-Dol, Clermont-Ferrand, France"},{"name":"10CHU de Clermont-Ferrand, Service de chirurgie maxillo-faciale, Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Caron","sequence":"additional","affiliation":[{"name":"11CHU Larrey-Rangueil, Service Endocrinologie et Maladies M\u00e9taboliques, P\u00f4le Cardio-Vasculaire et M\u00e9tabolique, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Tauveron","sequence":"additional","affiliation":[{"name":"1CHU de Clermont-Ferrand, Service d\u2019Endocrinologie, Diab\u00e9tologie et Maladies M\u00e9taboliques, Clermont-Ferrand, France"},{"name":"2Universit\u00e9 Clermont Auvergne, Facult\u00e9 de M\u00e9decine, Clermont-Ferrand, France"},{"name":"7Laboratoire GReD: UMR Universit\u00e9 Clermont Auvergne-CNRS 6293, INSERM U1103, Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Devoize","sequence":"additional","affiliation":[{"name":"3CHU Clermont-Ferrand, Service d\u2019Odontologie, Clermont-Ferrand, France"},{"name":"8Universit\u00e9 Clermont Auvergne, Inserm, Neuro-Dol, Clermont-Ferrand, France"},{"name":"12Universit\u00e9 Clermont Auvergne, Facult\u00e9 de Chirurgie Dentaire, Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Endocrine Connections"],"original-title":[],"link":[{"URL":"https:\/\/ec.bioscientifica.com\/view\/journals\/ec\/9\/8\/EC-20-0176.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ec.bioscientifica.com\/downloadpdf\/journals\/ec\/9\/8\/EC-20-0176.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:44:01Z","timestamp":1784555041000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/ec\/article\/9\/8\/824-833\/705"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":0,"journal-issue":{"issue":"8"},"URL":"https:\/\/doi.org\/10.1530\/ec-20-0176","relation":{},"ISSN":["2049-3614"],"issn-type":[{"value":"2049-3614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8]]}}}