{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T09:22:57Z","timestamp":1791364977209,"version":"4.3.1"},"reference-count":0,"publisher":"Bioscientifica","issue":"2","content-domain":{"domain":["ec.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The objective of this study was to analyze whether some auxological characteristics or a single basal gonadotropin measurement will be sufficient to distinguish the prepubertal from pubertal status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Auxologycal characteristics were recorded and serum LH and FSH were measured by immunochemiluminescence assays before and after GnRH stimulation test in a sample of 241 Caucasian girls with breast budding between 6- and 8-years old. Peak LH levels higher than 5 IU\/L were considered a pubertal response. Area under the curve, cut-off points, sensitivity, and specificity for auxologycal variables and basal gonadotropins levels were determined by receiver operating curves.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were no significant differences in age at onset, weight, height, BMI and height velocity between both groups. Bone age was significantly higher in pubertal girls (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.05), although with limited discriminatory capacity. The sensitivity and specificity for the basal LH levels were 89 and 82%, respectively, for a cut off point of 0.1 IU\/L. All girls in the pubertal group had a basal LH higher than 1.0 IU\/L (positive predictive value of 100%). There was a wide overlap of basal FSH and LH\/FSH ratio between prepubertal and pubertal girls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Auxologycal characteristics should not be used only in the differential diagnosis between prepubertal from pubertal status in 6- to 8-year-old girls. We found a high specificity of a single basal LH sample and it would be useful for establishing the diagnosis of puberty in this age group, reducing the need for GnRH stimulation testing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/ec-20-0651","type":"journal-article","created":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T11:00:26Z","timestamp":1610103626000},"page":"164-170","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-10","source":"Crossref","is-referenced-by-count":23,"title":["Clinical data and basal gonadotropins in the diagnosis of central precocious puberty in girls"],"prefix":"10.1530","volume":"10","author":[{"given":"Teodoro","family":"Dur\u00e1-Trav\u00e9","sequence":"first","affiliation":[{"name":"1Department of Pediatrics, School of Medicine, University of Navarra, Pamplona, Spain"},{"name":"2Department of Pediatrics, Navarra Hospital Complex, Pamplona, Spain"},{"name":"3Navarra Institute for Health Research (IdisNA), Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fidel","family":"Gallinas-Victoriano","sequence":"additional","affiliation":[{"name":"2Department of Pediatrics, Navarra Hospital Complex, Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Malumbres-Chacon","sequence":"additional","affiliation":[{"name":"2Department of Pediatrics, Navarra Hospital Complex, Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lotfi","family":"Ahmed-Mohamed","sequence":"additional","affiliation":[{"name":"2Department of Pediatrics, Navarra Hospital Complex, Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jes\u00fas Chueca","family":"-Guindulain","sequence":"additional","affiliation":[{"name":"2Department of Pediatrics, Navarra Hospital Complex, Pamplona, Spain"},{"name":"3Navarra Institute for Health Research (IdisNA), Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Berrade-Zubiri","sequence":"additional","affiliation":[{"name":"2Department of Pediatrics, Navarra Hospital Complex, Pamplona, Spain"},{"name":"3Navarra Institute for Health Research (IdisNA), Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Endocrine Connections"],"original-title":[],"link":[{"URL":"https:\/\/ec.bioscientifica.com\/view\/journals\/ec\/10\/2\/EC-20-0651.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ec.bioscientifica.com\/downloadpdf\/journals\/ec\/10\/2\/EC-20-0651.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:44:23Z","timestamp":1784555063000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/ec\/article\/10\/2\/164-170\/223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":0,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1530\/ec-20-0651","relation":{},"ISSN":["2049-3614"],"issn-type":[{"value":"2049-3614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2]]}}}