{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T16:37:37Z","timestamp":1793637457075,"version":"4.5.1"},"reference-count":0,"publisher":"Bioscientifica","issue":"8","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ec.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,8,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In addition to increased cardiovascular risk, patients with primary aldosteronism (PA) also suffer from impaired health-related quality of life (HRQoL) and psychological symptoms. We assessed for changes in HRQoL and depressive symptoms in a cohort of Asian patients with PA, after surgical and medical therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty-four patients with PA were prospectively recruited and completed questionnaires from 2017 to 2020. HRQoL was assessed using RAND-36 and EQ-5D-3L, and depressive symptoms were assessed using Beck Depression Inventory (BDI-II) at baseline, 6 months, and 1 year post-treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At 1 year post-treatment, significant improvement was observed in both physical and mental summative scores of RAND-36, +3.65,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.023, and +3.41,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.033, respectively, as well as four subscale domains (physical functioning, bodily pain, role emotional, and mental health). Significant improvement was also seen in EQ-5D dimension of anxiety\/depression at 1 year post-treatment. Patients treated with surgery (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200921) had significant improvement in EQ-5D index score post-treatment and better EQ-5D outcomes compared to the medical group (\n                      <jats:italic>n<\/jats:italic>\n                      = 13) at 1 year post-treatment. 37.9, 41.6 and 58.6% of patients had symptoms in the cognitive, affective and somatic domains of BDI-II, respectively. There was a significant improvement in the affective domain of BDI-II at 1 year post-treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Both surgical and medical therapy improve HRQoL and psychological symptoms in patients with PA, with surgery providing better outcomes. This highlights the importance of early diagnosis, accurate subtyping and appropriate treatment of PA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/ec-21-0125","type":"journal-article","created":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T11:23:13Z","timestamp":1625484193000},"page":"834-844","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-10","source":"Crossref","is-referenced-by-count":21,"title":["Improvement in quality of life and psychological symptoms after treatment for primary aldosteronism: Asian Cohort Study"],"prefix":"10.1530","volume":"10","author":[{"given":"Yen Kheng","family":"Tan","sequence":"first","affiliation":[{"name":"1Duke-NUS Medical School, SingHealth, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Heng","family":"Kwan","sequence":"additional","affiliation":[{"name":"2Department of Internal Medicine, Singapore General Hospital, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Choon Liang","family":"Teo","sequence":"additional","affiliation":[{"name":"3Department of Psychological Medicine, Changi General Hospital, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marieke","family":"Velema","sequence":"additional","affiliation":[{"name":"4Division of Endocrinology, Department of Internal Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaap","family":"Deinum","sequence":"additional","affiliation":[{"name":"5Division of Vascular Medicine, Department of Internal Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei Ting","family":"Tan","sequence":"additional","affiliation":[{"name":"6Department of Clinical Trials Research Unit, Changi General Hospital, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meifen","family":"Zhang","sequence":"additional","affiliation":[{"name":"7Department of Endocrinology, Changi General Hospital, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan Joo Ching","family":"Khoo","sequence":"additional","affiliation":[{"name":"7Department of Endocrinology, Changi General Hospital, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wann Jia","family":"Loh","sequence":"additional","affiliation":[{"name":"7Department of Endocrinology, Changi General Hospital, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linsey","family":"Gani","sequence":"additional","affiliation":[{"name":"7Department of Endocrinology, Changi General Hospital, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas F J","family":"King","sequence":"additional","affiliation":[{"name":"7Department of Endocrinology, Changi General Hospital, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eberta Jun Hui","family":"Tan","sequence":"additional","affiliation":[{"name":"7Department of Endocrinology, Changi General Hospital, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shui Boon","family":"Soh","sequence":"additional","affiliation":[{"name":"7Department of Endocrinology, Changi General Hospital, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa Shu Chuan","family":"Au","sequence":"additional","affiliation":[{"name":"7Department of Endocrinology, Changi General Hospital, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tunn Lin","family":"Tay","sequence":"additional","affiliation":[{"name":"7Department of Endocrinology, Changi General Hospital, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lily Mae Quevedo","family":"Dacay","sequence":"additional","affiliation":[{"name":"7Department of Endocrinology, Changi General Hospital, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keng Sin","family":"Ng","sequence":"additional","affiliation":[{"name":"8Department of Diagnostic Radiology, Changi General Hospital, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang Min","family":"Wong","sequence":"additional","affiliation":[{"name":"8Department of Diagnostic Radiology, Changi General Hospital, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew Siang Yih","family":"Wong","sequence":"additional","affiliation":[{"name":"9Department of Surgery, Changi General Hospital, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Foo Cheong","family":"Ng","sequence":"additional","affiliation":[{"name":"10Department of Urology, Changi General Hospital, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tar Choon","family":"Aw","sequence":"additional","affiliation":[{"name":"11Department of Laboratory Medicine, Changi General Hospital, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne Hui Bin","family":"Chan","sequence":"additional","affiliation":[{"name":"1Duke-NUS Medical School, SingHealth, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khim Leng","family":"Tong","sequence":"additional","affiliation":[{"name":"12Department of Cardiology, Changi General Hospital, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheldon Shao Guang","family":"Lee","sequence":"additional","affiliation":[{"name":"12Department of Cardiology, Changi General Hospital, Singapore, 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