{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:16:02Z","timestamp":1791314162171,"version":"4.3.1"},"reference-count":0,"publisher":"Bioscientifica","issue":"6","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ec.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,6,1]]},"abstract":"\n Objectives<\/jats:title>\n We aimed to identify and characterize potential factors, both individually and jointly as a nomogram, associated with short stature and pre-shortness in Chinese preschool-aged children.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Total of 9501 children aged 3\u20136 years were recruited from 30 kindergartens in Beijing and Tangshan from September to December 2020 using a stratified random sampling method. Effect-size estimates are expressed as odds ratio (OR) and 95% CI.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The prevalence of short stature and pre-shortness in preschool-aged children was 3.9% (\n n<\/jats:italic>\n \u2009= 375) and 13.1% (\n n<\/jats:italic>\n \u2009= 1616), respectively. Factors simultaneously associated with the significant risk for short stature, pre-shortness and both included BMI, paternal height, maternal height, birth weight, birth height, latter birth order (\u22652) and less parental patience to children. Besides, breastfeeding duration (\u226512 months) was exclusively associated with pre-shortness (OR, 95% CI,\n P<\/jats:italic>\n : 1.16, 1.01 to 1.33, 0.037), and childhood obesity with both short stature (3.45, 2.62 to 4.54, <0.001) and short stature\/pre-shortness (1.37, 1.15 to 1.64, <0.001). Modeling of significant factors in nomograms had descent prediction accuracies, with the C-index being 77.0, 70.1 and 71.2% for short stature, pre-shortness and both, respectively (all\n P<\/jats:italic>\n < 0.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Our findings indicate the joint contribution of inherited characteristics, nutrition status from the uterus to childhood, and family psychological environment to short stature and pre-shortness in Chinese preschool-aged children. Further validation in other independent groups is warranted.<\/jats:p>\n <\/jats:sec>","DOI":"10.1530\/ec-21-0147","type":"journal-article","created":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T13:54:10Z","timestamp":1621432450000},"page":"607-619","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-10","source":"Crossref","is-referenced-by-count":3,"title":["Identification and characterization of factors associated with short stature and pre-shortness in Chinese preschool-aged children"],"prefix":"10.1530","volume":"10","author":[{"given":"Min","family":"Yang","sequence":"first","affiliation":[{"name":"1Graduate School, Beijing University of Chinese Medicine, Beijing, China"},{"name":"3Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangling","family":"Deng","sequence":"additional","affiliation":[{"name":"1Graduate School, Beijing University of Chinese Medicine, Beijing, China"},{"name":"3Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunan","family":"Wang","sequence":"additional","affiliation":[{"name":"1Graduate School, Beijing University of Chinese Medicine, Beijing, China"},{"name":"3Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhou","sequence":"additional","affiliation":[{"name":"1Graduate School, Beijing University of Chinese Medicine, Beijing, China"},{"name":"3Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenquan","family":"Niu","sequence":"additional","affiliation":[{"name":"4Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixin","family":"Zhang","sequence":"additional","affiliation":[{"name":"2International Medical Services, China-Japan Friendship Hospital, Beijing, China"},{"name":"3Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Endocrine Connections"],"original-title":[],"link":[{"URL":"https:\/\/ec.bioscientifica.com\/view\/journals\/ec\/10\/6\/EC-21-0147.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ec.bioscientifica.com\/downloadpdf\/journals\/ec\/10\/6\/EC-21-0147.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:44:33Z","timestamp":1784555073000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/ec\/article\/10\/6\/607-619\/811"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,1]]},"references-count":0,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.1530\/ec-21-0147","relation":{},"ISSN":["2049-3614"],"issn-type":[{"value":"2049-3614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,1]]}}}