{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T23:56:05Z","timestamp":1788998165944,"version":"build-2803163510"},"reference-count":50,"publisher":"Bioscientifica","issue":"4","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ec.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,4,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Polycystic ovary syndrome (PCOS) encompasses endocrine, reproductive and metabolic disturbances. Abdominal pain and bowel movement disturbances are common complaints of PCOS patients. It remains uncertain whether the characteristic features of PCOS are associated with an increased incidence of irritable bowel syndrome (IBS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In the study, 133 patients with PCOS diagnosed according to international evidence\n                      <jats:italic>-<\/jats:italic>\n                      based guidelines and 72 age- and BMI-matched eumenorrheic controls were enrolled. Anthropometric measurements and biochemical and hormonal characteristics were collected. The Rome IV criteria were used for IBS diagnosis. Quality of life (QoL) and depressive symptoms were also assessed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>IBS symptom prevalence in PCOS was not significantly different than in controls. Hyperandrogenism and simple and visceral obesity did not appear to affect IBS prevalence in PCOS. There were no anthropometric, hormonal or biochemical differences between IBS-PCOS and non-IBS-PCOS patients, apart from IBS-PCOS patients being slightly older and having lower thyroid-stimulating hormone. Metabolic syndrome (MS) prevalence was higher in IBS-PCOS than non-IBS-PCOS. QoL appears to be significantly lower in IBS-PCOS compared to PCOS-only patients. The occurrence of depression was higher in IBS-PCOS vs non-IBS-PCOS patients. At least one alarm symptom was reported by 87.5% of IBS-PCOS; overall, this group experienced more alarm symptoms than the IBS-only group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Since a link between PCOS and IBS comorbidity and increased MS prevalence was noted, patients presenting with both conditions may benefit from early MS diagnostics and management. The high incidence of alarm symptoms in PCOS women in this study highlights the need for differential diagnosis of organic diseases that could mimic IBS symptoms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/ec-21-0309","type":"journal-article","created":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T09:28:05Z","timestamp":1646990885000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-10","source":"Crossref","is-referenced-by-count":10,"title":["Are patients with polycystic ovary syndrome more prone to irritable bowel syndrome?"],"prefix":"10.1530","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2116-4384","authenticated-orcid":true,"given":"Ma\u0142gorzata","family":"Ka\u0142u\u017cna","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3121-3055","authenticated-orcid":true,"given":"Pola","family":"Kompf","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Wachowiak-Ochma\u0144ska","sequence":"additional","affiliation":[{"name":"Heliodor \u015awi\u0119cicki Clinical Hospital, Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerzy","family":"Moczko","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Statistics, Poznan University of Medical Sciences, Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Kr\u00f3lczyk","sequence":"additional","affiliation":[{"name":"Chair and Department of Gastroenterology, Dietetics and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Janicki","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karol","family":"Szapel","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy, Poznan University of Medical Sciences, Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian","family":"Grzymis\u0142awski","sequence":"additional","affiliation":[{"name":"Chair and Department of Gastroenterology, Dietetics and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Rucha\u0142a","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5377-8834","authenticated-orcid":true,"given":"Katarzyna","family":"Ziemnicka","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Clinical Endocrinology","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1111\/cen.13795","article-title":"Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome","volume":"89","author":"Teede","year":"2018","unstructured":"Teede HJ\n\n\nMisso ML\n\n\nCostello MF\n\n\nDokras A\n\n\nLaven J\n\n\nMoran L\n\n\nPiltonen T\n\n\nNorman RJ\n\n & International PCOS Network. Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome. Clinical Endocrinology\n2018\n89\n251\u2013268. (https:\/\/doi.org\/10.1111\/cen.13795)3002465310.1111\/cen.13795"},{"key":"bib2","series-title":"Human Reproduction","first-page":"41","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)","volume":"19","year":"2004","unstructured":"Rotterdam ESHRE\/ASRM-Sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Human Reproduction\n2004\n19\n41\u201347. 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(https:\/\/doi.org\/10.1055\/s-0037-1603096)2865871110.1055\/s-0037-1603096"},{"key":"bib5","series-title":"Clinical Endocrinology","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1111\/cen.13477","article-title":"The risk of metabolic syndrome in polycystic ovary syndrome: a systematic review and meta-analysis","volume":"88","author":"Behboudi-Gandevani","year":"2018","unstructured":"Behboudi-Gandevani S\n\n\nAmiri M\n\n\nBidhendi Yarandi R\n\n\nNoroozzadeh M\n\n\nFarahmand M\n\n\nRostami Dovom M\n\n\nRamezani Tehrani F\n\n. The risk of metabolic syndrome in polycystic ovary syndrome: a systematic review and meta-analysis. Clinical Endocrinology\n2018\n88\n169\u2013184. (https:\/\/doi.org\/10.1111\/cen.13477)2893037810.1111\/cen.13477"},{"key":"bib6","series-title":"Nutrients","article-title":"Indirect predictors of visceral adipose tissue in women with polycystic ovary syndrome: a comparison of methods","volume":"13","author":"Kaluzna","year":"2021","unstructured":"Kaluzna M\n\n\nCzlapka-Matyasik M\n\n\nBykowska-Derda A\n\n\nMoczko J\n\n\nRuchala M\n\n\nZiemnicka K\n\n. Indirect predictors of visceral adipose tissue in women with polycystic ovary syndrome: a comparison of methods. Nutrients\n2021\n13 2494. (https:\/\/doi.org\/10.3390\/nu13082494)34444654"},{"key":"bib7","series-title":"Health and Quality of Life Outcomes","article-title":"Understanding polycystic ovary syndrome from the patient perspective: a concept elicitation patient interview study","volume":"15","author":"Martin","year":"2017","unstructured":"Martin ML\n\n\nHalling K\n\n\nEek D\n\n\nKrohe M\n\n\nPaty J\n\n. Understanding polycystic ovary syndrome from the patient perspective: a concept elicitation patient interview study. Health and Quality of Life Outcomes\n2017\n15 162. (https:\/\/doi.org\/10.1186\/s12955-017-0736-3)28821294"},{"key":"bib8","series-title":"International Journal of Clinical Practice","article-title":"Risk factors associated with intestinal permeability in an adult population: a systematic review","volume":"73","author":"Leech","year":"2019","unstructured":"Leech B\n\n\nMcIntyre E\n\n\nSteel A\n\n\nSibbritt D\n\n. Risk factors associated with intestinal permeability in an adult population: a systematic review. International Journal of Clinical Practice\n2019\n73 e13385. (https:\/\/doi.org\/10.1111\/ijcp.13385)"},{"key":"bib9","series-title":"Menopause","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1097\/GME.0000000000001226","article-title":"Correlates of sexual function among multi-ethnic middle-aged women: results from the study of Women\u2019s Health Across the Nation (SWAN)","volume":"25","author":"Avis","year":"2018","unstructured":"Avis NE\n\n\nZhao X\n\n\nJohannes CB\n\n\nOry M\n\n\nBrockwell S\n\n\nGreendale GA\n\n. Correlates of sexual function among multi-ethnic middle-aged women: results from the study of Women\u2019s Health Across the Nation (SWAN)\nMenopause\n2018\n25\n1244\u20131255. (https:\/\/doi.org\/10.1097\/GME.0000000000001226)10.1097\/GME.0000000000001226"},{"key":"bib10","series-title":"Clinical Epidemiology","first-page":"71","article-title":"The epidemiology of irritable bowel syndrome","volume":"6","author":"Canavan","year":"2014","unstructured":"Canavan C\n\n\nWest J\n\n\nCard T\n\n. 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(https:\/\/doi.org\/10.5056\/jnm18028)3087087810.5056\/jnm18028"},{"key":"bib14","series-title":"Journal of Korean Medical Science","doi-asserted-by":"publisher","first-page":"851","DOI":"10.3346\/jkms.2007.22.5.851","article-title":"Irritable bowel syndrome is more common in women regardless of the menstrual phase: a Rome II-based survey","volume":"22","author":"Lee","year":"2007","unstructured":"Lee SY\n\n\nKim JH\n\n\nSung IK\n\n\nPark HS\n\n\nJin CJ\n\n\nChoe WH\n\n\nKwon SY\n\n\nLee CH\n\n\nChoi KW\n\n. Irritable bowel syndrome is more common in women regardless of the menstrual phase: a Rome II-based survey. Journal of Korean Medical Science\n2007\n22\n851\u2013854. (https:\/\/doi.org\/10.3346\/jkms.2007.22.5.851)1798223410.3346\/jkms.2007.22.5.851"},{"key":"bib15","series-title":"Alimentary Pharmacology and Therapeutics","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1111\/j.1365-2036.2010.04409.x","article-title":"Meta-analysis: do irritable bowel syndrome symptoms vary between men and women?","volume":"32","author":"Adeyemo","year":"2010","unstructured":"Adeyemo MA\n\n\nSpiegel BM\n\n\nChang L\n\n. Meta-analysis: do irritable bowel syndrome symptoms vary between men and women?\nAlimentary Pharmacology and Therapeutics\n2010\n32\n738\u2013755. (https:\/\/doi.org\/10.1111\/j.1365-2036.2010.04409.x)2066278610.1111\/j.1365-2036.2010.04409.x"},{"key":"bib16","series-title":"Journal of Neurogastroenterology and Motility","doi-asserted-by":"publisher","first-page":"544","DOI":"10.5056\/jnm18082","article-title":"Sex-gender differences in irritable bowel syndrome","volume":"24","author":"Kim","year":"2018","unstructured":"Kim YS\n\n\nKim N\n\n. Sex-gender differences in irritable bowel syndrome. Journal of Neurogastroenterology and Motility\n2018\n24\n544\u2013558. (https:\/\/doi.org\/10.5056\/jnm18082)3034793410.5056\/jnm18082"},{"key":"bib17","series-title":"International Journal of Biological Sciences","doi-asserted-by":"publisher","first-page":"1504","DOI":"10.7150\/ijbs.25001","article-title":"Depressive symptoms in patients with irritable bowel syndrome: a meta-analysis of comparative studies","volume":"14","author":"Zhang","year":"2018","unstructured":"Zhang QE\n\n\nWang F\n\n\nQin G\n\n\nZheng W\n\n\nNg CH\n\n\nUngvari GS\n\n\nYuan Z\n\n\nMei S\n\n\nWang G\n\n\nXiang YT\n\n. Depressive symptoms in patients with irritable bowel syndrome: a meta-analysis of comparative studies. International Journal of Biological Sciences\n2018\n14\n1504\u20131512. (https:\/\/doi.org\/10.7150\/ijbs.25001)3026300310.7150\/ijbs.25001"},{"key":"bib18","series-title":"International Journal of Environmental Research and Public Health","article-title":"Determinants of quality of life and satisfaction with life in women with polycystic ovary syndrome","volume":"15","author":"Rzonca","year":"2018","unstructured":"Rzonca E\n\n\nBien A\n\n\nWdowiak A\n\n\nSzymanski R\n\n\nIwanowicz-Palus G\n\n. Determinants of quality of life and satisfaction with life in women with polycystic ovary syndrome. International Journal of Environmental Research and Public Health\n2018\n15 376. (https:\/\/doi.org\/10.3390\/ijerph15020376)29470449"},{"key":"bib19","series-title":"Human Reproduction","doi-asserted-by":"publisher","first-page":"1602","DOI":"10.1093\/humrep\/dey256","article-title":"Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome","volume":"33","author":"Teede","year":"2018","unstructured":"Teede HJ\n\n\nMisso ML\n\n\nCostello MF\n\n\nDokras A\n\n\nLaven J\n\n\nMoran L\n\n\nPiltonen T\n\n\nNorman RJ\n\n & International PCOS Network. Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome. Human Reproduction\n2018\n33\n1602\u20131618. (https:\/\/doi.org\/10.1093\/humrep\/dey256)3005296110.1093\/humrep\/dey256"},{"key":"bib20","series-title":"Circulation","first-page":"1640","article-title":"Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the study of obesity","volume":"120","author":"Alberti","year":"2009","unstructured":"Alberti KG\n\n\nEckel RH\n\n\nGrundy SM\n\n\nZimmet PZ\n\n\nCleeman JI\n\n\nDonato KA\n\n\nFruchart JC\n\n\nJames WP\n\n\nLoria CM\n\n\nSmith Jr SC\n\n\n\nHarmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the study of obesity. Circulation\n2009\n120\n1640\u20131645. (https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.109.192644)"},{"key":"bib21","series-title":"European Journal of Obstetrics, Gynecology, and Reproductive Biology","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.ejogrb.2017.08.011","article-title":"Ultrasonographic evaluation of intra-abdominal fat distribution and study of its influence on subclinical atherosclerosis in women with polycystic ovarian syndrome","volume":"217","author":"Tripathy","year":"2017","unstructured":"Tripathy P\n\n\nSahu A\n\n\nSahu M\n\n\nNagy A\n\n. Ultrasonographic evaluation of intra-abdominal fat distribution and study of its influence on subclinical atherosclerosis in women with polycystic ovarian syndrome. European Journal of Obstetrics, Gynecology, and Reproductive Biology\n2017\n217\n18\u201322. (https:\/\/doi.org\/10.1016\/j.ejogrb.2017.08.011)2885082110.1016\/j.ejogrb.2017.08.011"},{"key":"bib22","series-title":"Annals of Medicine","doi-asserted-by":"publisher","first-page":"328","DOI":"10.3109\/07853890109002086","article-title":"The 15D instrument of health-related quality of life: properties and applications","volume":"33","author":"Sintonen","year":"2001","unstructured":"Sintonen H\n\n\nThe 15D instrument of health-related quality of life: properties and applications. Annals of Medicine\n2001\n33\n328\u2013336. (https:\/\/doi.org\/10.3109\/07853890109002086)10.3109\/07853890109002086"},{"key":"bib23","series-title":"Quality of Life Research","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1007\/s11136-014-0787-4","article-title":"Estimating the minimum important change in the 15D scores","volume":"24","author":"Alanne","year":"2015","unstructured":"Alanne S\n\n\nRoine RP\n\n\nRasanen P\n\n\nVainiola T\n\n\nSintonen H\n\n. Estimating the minimum important change in the 15D scores. Quality of Life Research\n2015\n24\n599\u2013606. (https:\/\/doi.org\/10.1007\/s11136-014-0787-4)2514563710.1007\/s11136-014-0787-4"},{"key":"bib24","series-title":"Waist Circumference and Waist-Hip Ratio: Report of A WHO Expert Consultation G, 8\u201311 December 2008","year":"2011","unstructured":"World Health Organization. Waist Circumference and Waist-Hip Ratio: Report of A WHO Expert Consultation G, 8\u201311 December 2008. World Health Organization, 2011. (available at: https:\/\/apps.who.int\/iris\/handle\/10665\/44583)"},{"key":"bib25","series-title":"Journal of Clinical Endocrinology and Metabolism","doi-asserted-by":"publisher","first-page":"3666","DOI":"10.1210\/jcem.84.10.6079","article-title":"A critical evaluation of simple methods for the estimation of free testosterone in serum","volume":"84","author":"Vermeulen","year":"1999","unstructured":"Vermeulen A\n\n\nVerdonck L\n\n\nKaufman JM\n\n. A critical evaluation of simple methods for the estimation of free testosterone in serum. Journal of Clinical Endocrinology and Metabolism\n1999\n84\n3666\u20133672. (https:\/\/doi.org\/10.1210\/jcem.84.10.6079)1052301210.1210\/jcem.84.10.6079"},{"key":"bib26","series-title":"PLoS ONE","article-title":"Hyperandrogenemia in polycystic ovary syndrome: exploration of the role of free testosterone and androstenedione in metabolic phenotype","volume":"9","author":"Lerchbaum","year":"2014","unstructured":"Lerchbaum E\n\n\nSchwetz V\n\n\nRabe T\n\n\nGiuliani A\n\n\nObermayer-Pietsch B\n\n. Hyperandrogenemia in polycystic ovary syndrome: exploration of the role of free testosterone and androstenedione in metabolic phenotype. PLoS ONE\n2014\n9 e108263. (https:\/\/doi.org\/10.1371\/journal.pone.0108263)25310562"},{"key":"bib27","series-title":"Diabetologia","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","unstructured":"Matthews DR\n\n\nHosker JP\n\n\nRudenski AS\n\n\nNaylor BA\n\n\nTreacher DF\n\n\nTurner RC\n\n. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia\n1985\n28\n412\u2013419. (https:\/\/doi.org\/10.1007\/BF00280883)389982510.1007\/BF00280883"},{"key":"bib28","series-title":"JACC: Heart Failure","first-page":"531","article-title":"Insulin resistance and incident heart failure the ARIC study (atherosclerosis risk in communities)","volume":"1","author":"Vardeny","year":"2013","unstructured":"Vardeny O\n\n\nGupta DK\n\n\nClaggett B\n\n\nBurke S\n\n\nShah A\n\n\nLoehr L\n\n\nRasmussen-Torvik L\n\n\nSelvin E\n\n\nChang PP\n\n\nAguilar D\n\n\n\nInsulin resistance and incident heart failure the ARIC study (atherosclerosis risk in communities). JACC: Heart Failure\n2013\n1\n531\u2013536. (https:\/\/doi.org\/10.1016\/j.jchf.2013.07.006)24455475"},{"key":"bib29","series-title":"Clinical Chemistry","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1093\/clinchem\/18.6.499","article-title":"Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge","volume":"18","author":"Friedewald","year":"1972","unstructured":"Friedewald WT\n\n\nLevy RI\n\n\nFredrickson DS\n\n. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clinical Chemistry\n1972\n18\n499\u2013502. 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Systematic review of the comorbidity of irritable bowel syndrome with other disorders: what are the causes and implications?\nGastroenterology\n2002\n122\n1140\u20131156. (https:\/\/doi.org\/10.1053\/gast.2002.32392)1191036410.1053\/gast.2002.32392"},{"key":"bib44","series-title":"Journal of Women\u2019s Health","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1089\/jwh.2010.2541","article-title":"Associations between psychologic symptoms and life satisfaction in women with polycystic ovary syndrome","volume":"21","author":"Cipkala-Gaffin","year":"2012","unstructured":"Cipkala-Gaffin J\n\n\nTalbott EO\n\n\nSong MK\n\n\nBromberger J\n\n\nWilson J\n\n. Associations between psychologic symptoms and life satisfaction in women with polycystic ovary syndrome. Journal of Women\u2019s Health\n2012\n21\n179\u2013187. 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(https:\/\/doi.org\/10.1038\/sj.ijo.0801994)1208044010.1038\/sj.ijo.0801994"},{"key":"bib47","series-title":"European Journal of Gastroenterology and Hepatology","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1097\/MEG.0b013e32832ffd9b","article-title":"The relationship between symptoms, body mass index, gastrointestinal transit and stool frequency in patients with irritable bowel syndrome","volume":"22","author":"Sadik","year":"2010","unstructured":"Sadik R\n\n\nBjornsson E\n\n\nSimren M\n\n. The relationship between symptoms, body mass index, gastrointestinal transit and stool frequency in patients with irritable bowel syndrome. European Journal of Gastroenterology and Hepatology\n2010\n22\n102\u2013108. 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