{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:28:41Z","timestamp":1790710121049,"version":"4.1.0"},"reference-count":34,"publisher":"Bioscientifica","issue":"2","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ec.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,2,1]]},"abstract":"<jats:p>\n                    Hashimoto\u2019s thyroiditis (HT) is a very common organ-speci\ufb01c autoimmune disease characterized by lymphocyte infiltration and the destruction of thyroid follicular cells (TFCs), in which IFN-\u03b3 and chemokines play pivotal roles. Moreover, \u03b2-catenin has been implicated in the regulation of T cell infiltration. However, whether \u03b2-catenin is involved in Hashimoto\u2019s thyroiditis is unknown. Here, we examined \u03b2-catenin expression in thyroid tissues and investigated its role in the pathogenesis of HT. The results showed that \u03b2-catenin expression was markedly reduced in the thyroid tissues of HT patients; more importantly, IFN-\u03b3 treatment markedly reduced the expression of \u03b2-catenin and was accompanied by the secretion of chemokines such as CCL5, CXCL16, GRO-\u03b2, and GRO-\u03b3 in TFCs\n                    <jats:italic>in vitro<\/jats:italic>\n                    , which was attributed to GSK-3\u03b2\/\u03b2-catenin signaling pathway activation. Collectively, the decreased expression of \u03b2-catenin might contribute to IFN\u03b3-induced chemokine secretion and lymphocyte infiltration in the development of HT.\n                  <\/jats:p>","DOI":"10.1530\/ec-21-0451","type":"journal-article","created":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T06:53:01Z","timestamp":1643784781000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-10","source":"Crossref","is-referenced-by-count":11,"title":["Decreased \u03b2-catenin expression contributes to IFN\u03b3-induced chemokine secretion and lymphocyte infiltration in Hashimoto\u2019s thyroiditis"],"prefix":"10.1530","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8539-857X","authenticated-orcid":true,"given":"Fei","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Yancheng City No. 1 People\u2019s Hospital, Yancheng, China"},{"name":"Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2915-0921","authenticated-orcid":true,"given":"Chaoming","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Mou","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengcheng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Bu","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Jiangsu Health Vocational College, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyan","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Xuzhou Central Hospital, Xuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Neuroimmunomodulation","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1159\/000078438","article-title":"Th1 and Th2 serum cytokine profiles characterize patients with Hashimoto\u2019s thyroiditis (Th1) and Graves\u2019 disease (Th2)","volume":"11","author":"Phenekos","year":"2004","unstructured":"Phenekos CVryonidou AGritzapis ADBaxevanis CNGoula MPapamichail M. 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