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The demand for vitamin D supplementation becomes necessary; however, the consumption of vitamin D is not without risks, which its toxicity could have potentially serious consequences related to hypervitaminosis D, such as hypercalcemia and cerebral alterations. Thus, the present study describes the electroencephalographic changes caused by supraphysiological doses of vitamin D in the brain electrical dynamics and the electrocardiographic changes. After 4 days of treatment with vitamin D at a dose of 25,000 IU\/kg, the serum calcium levels found were increased in comparison with the control group. The electrocorticogram analysis found a reduction in wave activity in the delta, theta, alpha and beta frequency bands. For ECG was observed changes with shortened QT follow-up, which could be related to serum calcium concentration. This study presented important evidence about the cerebral and cardiac alterations caused by high doses of vitamin D, indicating valuable parameters in the screening and decision-making process for diagnosing patients with symptoms suggestive of intoxication.<\/jats:p>","DOI":"10.1530\/ec-21-0457","type":"journal-article","created":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T12:19:58Z","timestamp":1644581998000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-10","source":"Crossref","is-referenced-by-count":5,"title":["100 YEARS OF VITAMIN D: Supraphysiological doses of vitamin D changes brainwave activity patterns in rats"],"prefix":"10.1530","volume":"11","author":[{"given":"Gabriella Oliveira","family":"Lima","sequence":"first","affiliation":[{"name":"Laboratory of Pharmacology and Toxicology of Natural Products, Institute of Biological Sciences, Federal University of Par\u00e1, Bel\u00e9m, Par\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7878-3450","authenticated-orcid":true,"given":"Alex Luiz","family":"Menezes da Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology and Toxicology of Natural Products, Institute of Biological Sciences, Federal University of Par\u00e1, Bel\u00e9m, Par\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julianne Elba Cunha","family":"Azevedo","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology and Toxicology of Natural Products, Institute of Biological Sciences, Federal University of Par\u00e1, Bel\u00e9m, Par\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chirlene Pinheiro","family":"Nascimento","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology and Toxicology of Natural Products, Institute of Biological Sciences, Federal University of Par\u00e1, Bel\u00e9m, Par\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luana Rodrigues","family":"Vieira","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology and Toxicology of Natural Products, Institute of Biological Sciences, Federal University of Par\u00e1, Bel\u00e9m, Par\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira Otake","family":"Hamoy","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology and Toxicology of Natural Products, Institute of Biological Sciences, Federal University of Par\u00e1, Bel\u00e9m, Par\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luan","family":"Oliveira Ferreira","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Neuropathology, Institute of Biological Sciences, Federal University of Par\u00e1, Bel\u00e9m, Par\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f4nica Regina Lobato Oliveira","family":"Bahia","sequence":"additional","affiliation":[{"name":"Multidisciplinary Laboratory of Animal Morphology, Institute of Biological Sciences, Federal University of Par\u00e1, Bel\u00e9m, Par\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilton Akio","family":"Muto","sequence":"additional","affiliation":[{"name":"Amazon Bioactive Compounds Valorization Center, Institute of Biological Sciences, Federal University of Par\u00e1, Bel\u00e9m, Par\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6226-4269","authenticated-orcid":true,"given":"Dielly Catrina Favacho","family":"Lopes","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Neuropathology, Institute of Biological Sciences, Federal University of Par\u00e1, Bel\u00e9m, Par\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mois\u00e9s","family":"Hamoy","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology and Toxicology of Natural Products, Institute of Biological Sciences, Federal University of Par\u00e1, Bel\u00e9m, Par\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Nutrients","article-title":"Development of vitamin D toxicity from overcorrection of vitamin D deficiency: a review of case reports","volume":"10","author":"Galior","year":"2018","unstructured":"Galior KGrebe SSingh R. 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