{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:09:15Z","timestamp":1790752155022,"version":"4.1.0"},"reference-count":72,"publisher":"Bioscientifica","issue":"5","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ec.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,5,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The two-fold aim of this study was: (i) to determine the effects of undernutrition on the myokines in patients with restrictive anorexia nervosa (AN) and (ii) to examine the potential link between myokines and bone parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this study, 42 young women with restrictive AN and 42 age-matched controls (CON) (mean age, 18.5 \u00b1 4.2 years and 18.6 \u00b1 4.2 years, respectively) were enrolled. aBMD and body composition were determined with DXA. Resting energy expenditure (REEm), a marker of energy status, was indirectly assessed by calorimetry. Bone turnover markers and myokines (follistatin, myostatin and irisin) were concomitantly evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>AN patients presented low aBMD at all bone sites. REEm, bone formation markers, myostatin and IGF-1 were significantly lower, whereas the bone resorption marker and follistatin were higher in AN compared with controls. No difference was observed between groups for irisin levels. When the whole population was studied, among myokines, only myostatin was positively correlated with aBMD at all bone sites. However, multiple regression analyses showed that in the AN group, the independent variables for aBMD were principally amenorrhoea duration, lean tissue mass (LTM) and procollagen type I N-terminal propeptide (PINP). For CON, the independent variables for aBMD were principally LTM, age and PINP. Whatever the group analysed, none of the myokines appeared as explicative independent variables of aBMD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study demonstrated that despite the altered myokine levels in patients with AN, their direct effect on aBMD loss and bone turnover alteration seems limited in comparison with other well-known disease-related factors such as oestrogen deprivation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/ec-21-0488","type":"journal-article","created":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T06:54:45Z","timestamp":1651820085000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-10","source":"Crossref","is-referenced-by-count":14,"title":["In patients with anorexia nervosa, myokine levels are altered but are not associated with bone mineral density loss and bone turnover alteration"],"prefix":"10.1530","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1727-1048","authenticated-orcid":true,"given":"Laurent","family":"Ma\u00efmoun","sequence":"first","affiliation":[{"name":"D\u00e9partement de M\u00e9decine Nucl\u00e9aire, H\u00f4pital Lapeyronie, Centre Hospitalier R\u00e9gional Universitaire (CHU) Montpellier, Montpellier, France"},{"name":"PhyMedExp, Universit\u00e9 de Montpellier, INSERM, CNRS, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Mariano-Goulart","sequence":"additional","affiliation":[{"name":"D\u00e9partement de M\u00e9decine Nucl\u00e9aire, H\u00f4pital Lapeyronie, Centre Hospitalier R\u00e9gional Universitaire (CHU) Montpellier, Montpellier, France"},{"name":"PhyMedExp, Universit\u00e9 de Montpellier, INSERM, CNRS, Montpellier, 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(https:\/\/doi.org\/10.1210\/jc.2003-030532)10.1210\/jc.2003-030532"},{"key":"bib3","series-title":"Bone","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.bone.2019.03.007","article-title":"Suboptimal bone microarchitecure in adolescent girls with obesity compared to normal-weight controls and girls with anorexia nervosa","volume":"122","author":"Singhal","year":"2019","unstructured":"Singhal VSanchita SMalhotra SBose AFlores LPTValera RStanford FCSlattery MRosenblum JGoldstein MASuboptimal bone microarchitecure in adolescent girls with obesity compared to normal-weight controls and girls with anorexia nervosa. Bone2019122246\u2013253. 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(https:\/\/doi.org\/10.1210\/jc.2019-00843)3121958010.1210\/jc.2019-00843"},{"key":"bib5","series-title":"Journal of Pediatrics","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1067\/mpd.2002.125003","article-title":"Physiologic regulators of bone turnover in young women with anorexia nervosa","volume":"141","author":"Gordon","year":"2002","unstructured":"Gordon CMGoodman EEmans SJGrace EBecker KARosen CJGundberg CMLeboff MS. Physiologic regulators of bone turnover in young women with anorexia nervosa. Journal of Pediatrics200214164\u201370. (https:\/\/doi.org\/10.1067\/mpd.2002.125003)1209185310.1067\/mpd.2002.125003"},{"key":"bib6","series-title":"Journal of Clinical Endocrinology and Metabolism","first-page":"2049","article-title":"Severity of osteopenia in estrogen-deficient women with anorexia nervosa and hypothalamic amenorrhea","volume":"84","author":"Grinspoon","year":"1999","unstructured":"Grinspoon SMiller KCoyle CKrempin JArmstrong CPitts SHerzog DKlibanski A. Severity of osteopenia in estrogen-deficient women with anorexia nervosa and hypothalamic amenorrhea. Journal of Clinical Endocrinology and Metabolism1999842049\u20132055. (https:\/\/doi.org\/10.1210\/jcem.84.6.5792)10372709"},{"key":"bib7","series-title":"Mayo Clinic Proceedings","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1016\/S0025-6196(11)63994-3","article-title":"Long-term fracture risk among women with anorexia nervosa: a population-based cohort study","volume":"74","author":"Lucas","year":"1999","unstructured":"Lucas ARMelton LJ3rdCrowson CSO\u2019Fallon WM. Long-term fracture risk among women with anorexia nervosa: a population-based cohort study. Mayo Clinic Proceedings199974972\u2013977. (https:\/\/doi.org\/10.4065\/74.10.972)1091886210.1016\/S0025-6196(11)63994-3"},{"key":"bib8","series-title":"American Journal of Clinical Nutrition","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1093\/ajcn\/50.4.767","article-title":"Decreased thyroidal triiodothyronine secretion in patients with anorexia nervosa: influence of weight recovery","volume":"50","author":"Kiyohara","year":"1989","unstructured":"Kiyohara KTamai HTakaichi YNakagawa TKumagai LF. Decreased thyroidal triiodothyronine secretion in patients with anorexia nervosa: influence of weight recovery. American Journal of Clinical Nutrition198950767\u2013772. 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(https:\/\/doi.org\/10.1203\/00006450-200204000-00016)1191933610.1203\/00006450-200204000-00016"},{"key":"bib10","series-title":"Journal of Clinical Endocrinology and Metabolism","doi-asserted-by":"publisher","first-page":"e1536","DOI":"10.1210\/clinem\/dgz259","article-title":"Specific effects of anorexia nervosa and obesity on bone mineral density and bone turnover in young women","volume":"105","author":"Maimoun","year":"2020","unstructured":"Maimoun LGarnero PMura TNocca DLefebvre PPhilibert PSeneque MGaspari LVauchot FCourtet PSpecific effects of anorexia nervosa and obesity on bone mineral density and bone turnover in young women. Journal of Clinical Endocrinology and Metabolism2020105e1536\u2013e1548. (https:\/\/doi.org\/10.1210\/clinem\/dgz259)10.1210\/clinem\/dgz259"},{"key":"bib11","series-title":"Calcified Tissue International","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1007\/s00223-008-9173-y","article-title":"Factors influencing changes in bone mineral density in patients with anorexia nervosa-related osteoporosis: the effect of hormone replacement therapy","volume":"83","author":"Legroux-Gerot","year":"2008","unstructured":"Legroux-Gerot IVignau JCollier FCortet B. Factors influencing changes in bone mineral density in patients with anorexia nervosa-related osteoporosis: the effect of hormone replacement therapy. Calcified Tissue International200883315\u2013323. (https:\/\/doi.org\/10.1007\/s00223-008-9173-y)1883667510.1007\/s00223-008-9173-y"},{"key":"bib12","series-title":"Calcified Tissue International","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1007\/s00223-007-9038-9","article-title":"Evaluation of bone loss and its mechanisms in anorexia nervosa","volume":"81","author":"Legroux-Gerot","year":"2007","unstructured":"Legroux-Gerot IVignau JD\u2019Herbomez MCollier FMarchandise XDuquesnoy BCortet B. Evaluation of bone loss and its mechanisms in anorexia nervosa. Calcified Tissue International200781174\u2013182. (https:\/\/doi.org\/10.1007\/s00223-007-9038-9)1766814310.1007\/s00223-007-9038-9"},{"key":"bib13","series-title":"Osteoporosis International","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1007\/s00198-015-3223-x","article-title":"Evidence of a link between resting energy expenditure and bone remodelling, glucose homeostasis and adipokine variations in adolescent girls with anorexia nervosa","volume":"27","author":"Maimoun","year":"2016","unstructured":"Maimoun LGuillaume SLefebvre PPhilibert PBertet HPicot MCGaspari LParis FSeneque MDupuys AMEvidence of a link between resting energy expenditure and bone remodelling, glucose homeostasis and adipokine variations in adolescent girls with anorexia nervosa. Osteoporosis International201627135\u2013146. 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British Journal of Hospital Medicine201879253\u2013258. (https:\/\/doi.org\/10.12968\/hmed.2018.79.5.253)2972722810.12968\/hmed.2018.79.5.253"},{"key":"bib16","series-title":"Spinal Cord","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1038\/sj.sc.3101832","article-title":"Bone loss in spinal cord-injured patients: from physiopathology to therapy","volume":"44","author":"Maimoun","year":"2006","unstructured":"Maimoun LFattal CMicallef JPPeruchon ERabischong P. Bone loss in spinal cord-injured patients: from physiopathology to therapy. Spinal Cord200644203\u2013210. (https:\/\/doi.org\/10.1038\/sj.sc.3101832)1615807510.1038\/sj.sc.3101832"},{"key":"bib17","series-title":"Journal of Bone and Mineral Research","first-page":"721","article-title":"Low skeletal muscle mass is associated with poor structural parameters of bone and impaired balance in elderly men \u2013 the MINOS study","volume":"20","author":"Szulc","year":"2005","unstructured":"Szulc PBeck TJMarchand FDelmas PD. Low skeletal muscle mass is associated with poor structural parameters of bone and impaired balance in elderly men \u2013 the MINOS study. Journal of Bone and Mineral Research200520721\u2013729. (https:\/\/doi.org\/10.1359\/JBMR.041230)15824844"},{"key":"bib18","series-title":"Bone","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1016\/S8756-3282(02)00707-X","article-title":"Effects of biomechanical stress on bones in animals","volume":"30","author":"Burr","year":"2002","unstructured":"Burr DBRobling AGTurner CH. Effects of biomechanical stress on bones in animals. Bone200230781\u2013786. (https:\/\/doi.org\/10.1016\/s8756-3282(0200707-x)1199692010.1016\/S8756-3282(02)00707-X"},{"key":"bib19","series-title":"Journal of Clinical Endocrinology and Metabolism","doi-asserted-by":"publisher","first-page":"1640","DOI":"10.1210\/jc.2006-0572","article-title":"Relationship of obesity with osteoporosis","volume":"92","author":"Zhao","year":"2007","unstructured":"Zhao LJLiu YJLiu PYHamilton JRecker RRDeng HW. Relationship of obesity with osteoporosis. Journal of Clinical Endocrinology and Metabolism2007921640\u20131646. (https:\/\/doi.org\/10.1210\/jc.2006-0572)1729907710.1210\/jc.2006-0572"},{"key":"bib20","series-title":"Journal of Cellular Biochemistry","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1002\/jcb.25040","article-title":"Interactions between muscle tissues and bone metabolism","volume":"116","author":"Kawao","year":"2015","unstructured":"Kawao NKaji H. Interactions between muscle tissues and bone metabolism. Journal of Cellular Biochemistry2015116687\u2013695. (https:\/\/doi.org\/10.1002\/jcb.25040)2552143010.1002\/jcb.25040"},{"key":"bib21","series-title":"Current Opinion in Pharmacology","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.coph.2017.05.005","article-title":"Muscle as a paracrine and endocrine organ","volume":"34","author":"Giudice","year":"2017","unstructured":"Giudice JTaylor JM. Muscle as a paracrine and endocrine organ. Current Opinion in Pharmacology20173449\u201355. (https:\/\/doi.org\/10.1016\/j.coph.2017.05.005)2860565710.1016\/j.coph.2017.05.005"},{"key":"bib22","series-title":"Nature Reviews: Endocrinology","first-page":"457","article-title":"Muscles, exercise and obesity: skeletal muscle as a secretory organ","volume":"8","author":"Pedersen","year":"2012","unstructured":"Pedersen BKFebbraio MA. Muscles, exercise and obesity: skeletal muscle as a secretory organ. Nature Reviews: Endocrinology20128457\u2013465. (https:\/\/doi.org\/10.1038\/nrendo.2012.49)22473333"},{"key":"bib23","series-title":"Calcified Tissue International","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/s00223-001-1109-8","article-title":"Bone mineral content and density in the humerus of adult myostatin-deficient mice","volume":"71","author":"Hamrick","year":"2002","unstructured":"Hamrick MWMcPherron ACLovejoy CO. Bone mineral content and density in the humerus of adult myostatin-deficient mice. Calcified Tissue International20027163\u201368. (https:\/\/doi.org\/10.1007\/s00223-001-1109-8)1206086510.1007\/s00223-001-1109-8"},{"key":"bib24","series-title":"Anatomical Record: Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology","first-page":"388","article-title":"Increased bone mineral density in the femora of GDF8 knockout mice","volume":"272","author":"Hamrick","year":"2003","unstructured":"Hamrick MWIncreased bone mineral density in the femora of GDF8 knockout mice. Anatomical Record: Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology2003272388\u2013391. (https:\/\/doi.org\/10.1002\/ar.a.10044)"},{"key":"bib25","series-title":"Bone","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/S8756-3282(00)00339-2","article-title":"Femoral morphology and cross-sectional geometry of adult myostatin-deficient mice","volume":"27","author":"Hamrick","year":"2000","unstructured":"Hamrick MWMcPherron ACLovejoy COHudson J. Femoral morphology and cross-sectional geometry of adult myostatin-deficient mice. Bone200027343\u2013349. (https:\/\/doi.org\/10.1016\/s8756-3282(0000339-2)1096234410.1016\/S8756-3282(00)00339-2"},{"key":"bib26","series-title":"Nature","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/387083a0","article-title":"Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member","volume":"387","author":"McPherron","year":"1997","unstructured":"McPherron ACLawler AMLee SJ. Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member. Nature199738783\u201390. (https:\/\/doi.org\/10.1038\/387083a0)913982610.1038\/387083a0"},{"key":"bib27","series-title":"Acta Physiologica","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1111\/j.1748-1716.2012.02423.x","article-title":"The central role of myostatin in skeletal muscle and whole body homeostasis","volume":"205","author":"Elliott","year":"2012","unstructured":"Elliott BRenshaw DGetting SMackenzie R. The central role of myostatin in skeletal muscle and whole body homeostasis. Acta Physiologica2012205324\u2013340. 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(https:\/\/doi.org\/10.1002\/mus.25268)2746280410.1002\/mus.25268"},{"key":"bib31","series-title":"Developmental Biology","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.ydbio.2004.01.046","article-title":"Follistatin complexes myostatin and antagonises myostatin-mediated inhibition of myogenesis","volume":"270","author":"Amthor","year":"2004","unstructured":"Amthor HNicholas GMcKinnell IKemp CFSharma MKambadur RPatel K. Follistatin complexes myostatin and antagonises myostatin-mediated inhibition of myogenesis. Developmental Biology200427019\u201330. 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Implications of exercise-induced adipo-myokines in bone metabolism. Endocrine201654284\u2013305. (https:\/\/doi.org\/10.1007\/s12020-015-0834-0)2671819110.1007\/s12020-015-0834-0"},{"key":"bib35","series-title":"PNAS","doi-asserted-by":"publisher","first-page":"12157","DOI":"10.1073\/pnas.1516622112","article-title":"The myokine irisin increases cortical bone mass","volume":"112","author":"Colaianni","year":"2015","unstructured":"Colaianni GCuscito CMongelli TPignataro PBuccoliero CLiu PLu PSartini LDi Comite MMori GThe myokine irisin increases cortical bone mass. PNAS201511212157\u201312162. 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