{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:17:07Z","timestamp":1784557027905,"version":"3.55.0"},"reference-count":85,"publisher":"Bioscientifica","issue":"3","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ec.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,3,1]]},"abstract":"<jats:p>Multiple endocrine neoplasia type 1 (MEN1) is the most common cause of hereditary primary hyperparathyroidism (PHPT). Bone disorders are considered one of the key symptoms in PHPT present with the significant reduction in bone mineral density and low-energy fractures. Previously, these bone disorders were believed to be caused solely by the increase in the level of parathyroid hormone and its subsequent effect on bone resorption. The current paradigm, however, states that the mutations in the menin gene, which cause the development of MEN1, can also affect the metabolism of the cells of the osteoid lineage. This review analyzes both the proven and the potential intracellular mechanisms through which menin can affect bone metabolism.<\/jats:p>","DOI":"10.1530\/ec-21-0494","type":"journal-article","created":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T12:19:58Z","timestamp":1644581998000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-10","source":"Crossref","is-referenced-by-count":7,"title":["The role of menin in bone pathology"],"prefix":"10.1530","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2669-9457","authenticated-orcid":true,"given":"Anna","family":"Gorbacheva","sequence":"first","affiliation":[{"name":"Endocrinology Research Center, Moscow, Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6667-062X","authenticated-orcid":true,"given":"Anna","family":"Eremkina","sequence":"additional","affiliation":[{"name":"Endocrinology Research Center, Moscow, Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daria","family":"Goliusova","sequence":"additional","affiliation":[{"name":"Endocrinology Research Center, Moscow, Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Krupinova","sequence":"additional","affiliation":[{"name":"Endocrinology Research Center, Moscow, Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Mokrysheva","sequence":"additional","affiliation":[{"name":"Endocrinology Research Center, Moscow, Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Journal of Clinical Endocrinology and Metabolism","doi-asserted-by":"publisher","first-page":"2990","DOI":"10.1210\/jc.2012-1230","article-title":"Clinical practice guidelines for multiple endocrine neoplasia type 1 (MEN1)","volume":"97","author":"Thakker","year":"2012","unstructured":"Thakker RVNewey PJWalls GVBilezikian JDralle HEbeling PRMelmed SSakurai ATonelli FBrandi MLClinical practice guidelines for multiple endocrine neoplasia type 1 (MEN1). 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